Results 191 to 200 of about 4,277,838 (300)

An efficient ranking deep neural network algorithm for the prediction of Ca2+ binding sites of the protein. [PDF]

PLoS One
Parwekar P, Gourinath S, Jain J, Gundagatti S, Ali J, Gupta P, Butkovic A.   +6 more
europepmc   +1 more source

Chemoproteomic Identification of AKT2 as a Paclitaxel‐Binding Protein via C─C Bond‐Linked Probe PTX‐4 in Paclitaxel‐Resistant Breast Cancer

Advanced Science, EarlyView.
ABSTRACT Breast cancer remains one of the most prevalent malignancies among women, and taxane‐based chemotherapies such as paclitaxel and docetaxel are central to standard treatment regimens. However, drug resistance in breast cancer limits therapeutic efficacy and contributes to recurrence and metastasis.
Kai Wang, Yuqing Yuan, Wei Shen, Xiuxiu Yang, Xiaokang Wu, Haihua Zhou, Yi Hu, Qing Zhu   +7 more
wiley   +1 more source

Using ¹⁹F NMR to quantify enthalpy-entropy compensation in protein-protein interactions. [PDF]

Magn Reson Lett
Redvanly TW, Pielak GJ.
europepmc   +1 more source

BAP31 Drives Cartilage Calcification through Disruption of Autophagosome–Lysosome Fusion in Osteoarthritis

Advanced Science, EarlyView.
Mechanical stress activates BAP31 in chondrocytes. BAP31 competes with ATG14 for binding to STX17, disrupting the STX17–ATG14 complex required for autophagosome–lysosome fusion. The resultant autophagic flux blockade drives the generation of autophagy‐derived exosomes, which mediate pathological cartilage calcification in OA. Chondrocyte‐targeted BAP31
Zhi‐hua Xu, Ruo‐xin Wang, Feng He, Qian Liu, Fu‐yin Li, Min Hui, Yu‐qian Shi, Yu Jiang, Qing‐hua Li, Jun‐wen Jing, Shi‐bin Yu, Li‐tian Ma, Qian‐nan Niu, Mian Zhang   +13 more
wiley   +1 more source

GTPase cycle and ER membrane regulate cargo handover during cotranslational protein targeting. [PDF]

Sci Adv
Qian R, Gora RJ, Chung S, Lee JH, Chandrasekar S, Wang MF, Weiss S, Shan SO.   +7 more
europepmc   +1 more source

The determination of the tertiary dissociation constant of phosphoric acid [PDF]

Biochemical Journal, 1929
openaire   +2 more sources

Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV

Advanced Science, EarlyView.
Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes, Gabriela Silva, Mafalda Aleixo, Marta Gomes, Daniel Simão, Stephan J. Holtkamp, Diana D. Lobo, Pradeep Harish, Rosalind Jenkins, Lekh N. Dahal, Rui J. Nobre, Luís de Pereira de Almeida, Mark Trautwein, Paula M. Alves, Catarina Brito   +14 more
wiley   +1 more source

High performance organic solar cell enabled by manipulating the exciton dissociation and charge transfer via dielectric engineering. [PDF]

Nat Commun
Wei Y, Gu X, Shi X, Zhang M, Lv J, Bai X, Wang L, Zhang X, Meng X, Zhang J, Hao X, Peng Q, Cai Y, Huang H.   +13 more
europepmc   +1 more source

Recent Advances in Laser‐Induced Graphene‐Based Gas Sensors: From Sensing Mechanisms to Biomedical Applications

Advanced Science, EarlyView.
Laser‐induced graphene (LIG) provides a scalable, laser‐direct‐written route to porous graphene architecture with tunable chemistry and defect density. Through heterojunction engineering, catalytic functionalization, and intrinsic self‐heating, LIG achieves highly sensitive and selective detection of NOX, NH3, H2, and humidity, supporting next ...
Md Abu Sayeed Biswas, Ankan Dutta, Shuvendu Das, Abu Musa Abdullah, Wanqing Zhang, Fatema Tuz Zohra, Huanyu Cheng   +6 more
wiley   +1 more source

Impact of Time, Temperature, and Conformational Changes on the Characterization of Cardiotonic Steroid-Na⁺/K⁺-ATPase Interactions. [PDF]

J Membr Biol
Azalim-Neto P, Barbosa L, Scavone C, Quintas LEM.   +3 more
europepmc   +1 more source