Results 201 to 210 of about 167,504 (265)

Dysregulation of the MACF1‐Rab14/KIF16B‐FGFR Vesicular Trafficking Axis Skews MSC Lineage Commitment in Glucocorticoid‐Induced Osteoporosis

Advanced Science, EarlyView.
Under normal conditions, MACF1 interacts with Rab14 and facilitates KIF16B‐mediated FGFR vesicle trafficking along microtubules to the plasma membrane, thereby supporting BMSC differentiation. In contrast, chronic GC exposure suppresses MACF1 expression, disrupting this transport and causing intracellular FGFR retention, which blunts osteogenic ...
Peihong Su, Ye Tian, Fan Zhao, Jing Li, Suryaji Patil, Chunyu Zhu, Yujia Tian, Junrong Wang, Jiating Liu, Aoqi Xiang, Hua Guan, Lusha Zhang, Xiaochang Chen, Airong Qian, Qi Yu   +14 more
wiley   +1 more source

A Small‐Molecule DEPTAC Rescues Cognitive Deficits by Targeted Dephosphorylation of Pathological Tau

Advanced Science, EarlyView.
TP2 is a fully synthetic small‐molecule dephosphorylation‐targeting chimera that recruits endogenous PP2A‐Bα to Tau, enabling targeted removal of pathological phosphate modifications. In two tauopathy mouse models, systemic TP2 reduces Tau pathology, preserves neuronal and synaptic integrity, improves neuroimmune homeostasis, and rescues cognition ...
Fei Sun, Yang Liu, Qiuzhi Zhou, Qingyuan Hu, Weixia Wang, Yue Xiao, Jingfen Su, Guanting Liu, Miaomiao Sun, Lixia Chen, Hua Li, Ying Yang, Jian‐Zhi Wang   +12 more
wiley   +1 more source

α-Halogenated Curcumins Enhance the Binding Affinity and Induced Structural Alterations to Amyloid-β Protein in Alzheimer's Disease. [PDF]

Int J Mol Sci
Khan MA, Chinnappan R, Andole S, Akif M, Mir TA, Yaqinuddin A, Pham PT, Bader MM.   +7 more
europepmc   +1 more source

F7 Drives Gastric Cancer Metastasis Through Anoikis Resistance and Tumor Microenvironment Remodeling

Advanced Science, EarlyView.
ABSTRACT Coagulation factor VII (F7) has been implicated in tumor progression; however, its role in gastric cancer metastasis and immune evasion remains incompletely understood. In this study, we identified F7 as a clinically relevant driver of gastric cancer.
Lei Gao, Qinying Han, Yunpeng Wang, Xuemei Li, Bofang Wang, Baohong Gu, Weidong Li, Lin Xiang, Ying Zhang, Hao Chen   +9 more
wiley   +1 more source

Curated digital datasets of acid dissociation constants in dipolar aprotic solvents. [PDF]

RSC Adv
Zheng JW, Leito I, Tshepelevitsh S, Green WH.   +3 more
europepmc   +1 more source

LB-PaCS-MD Guided Simulations Reveal Transient Stabilization during TCR-pMHC Dissociation. [PDF]

J Chem Inf Model
Karnchanapandh K, Songpipat P, Hanpaibool C, Harada R, Hengphasatporn K, Shigeta Y, Rungrotmongkol T.   +6 more
europepmc   +1 more source

A kinetic model for polyhydroxyalkanoates production by Cupriavidus necator using dark fermentation effluents. [PDF]

Biodegradation
Caro I, Romero-Vargas A, Díaz MJ, Huertas J.   +3 more
europepmc   +1 more source

CLDN18.2 antibody design with protein language models: A deep learning optimization framework. [PDF]

PLoS Comput Biol
Qu T, Yuan L, Cui W, Tang J, Bing Z, Xu X, Duan J, Yang Q, Cai H.   +8 more
europepmc   +1 more source

Enabling molecular signaling with temperature and ionic-strength independence or programmable dependence. [PDF]

Nat Commun
Korenkov ES, Nikitin MP.
europepmc   +1 more source

An efficient ranking deep neural network algorithm for the prediction of Ca2+ binding sites of the protein. [PDF]

PLoS One
Parwekar P, Gourinath S, Jain J, Gundagatti S, Ali J, Gupta P, Butkovic A.   +6 more
europepmc   +1 more source