Results 41 to 50 of about 4,277,838 (300)
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
II.—The dissociation constants of very weak acids [PDF]
J. Chem. Soc., Trans., 1900 n ...
Walker, James, Cormack, William
openaire +1 more source
, 2016 Thermodynamics, stoichiometry, and dissociation constant of albumin with GML, lauric acid or glycerol.
Michael S. Zhang (3233793) +1 more
core +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Kinetics and Mechanism of Mn(II) Catalyzed Periodate Oxidation of p-anisidine: Effect of pH
Bulletin of Chemical Reaction Engineering & Catalysis, 2014 The stoichiometry for the initial part of the reaction, Mn(II) catalysed periodate oxidation of p-anisidine (PMA), has been found to be 1 mol of PMA consuming 2 mol of periodate ion.
Rajneesh Dutt Kaushik +4 more
doaj +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Apparent Dissociation Constant of a Porphyrin
, 2023 The purpose of this laboratory is to determine the apparent acid dissociation constant, a, by estimating the pa value of a porphyrin using visible spectrophotometry.
Ballester, Maria, Castro, Victor
core +1 more source
Dissociation Constants of Thiolactic Acid
Zeitschrift für Physikalische Chemie, 1971 The acid dissociation constants of thiolactic acid have been determined potentiometrically and polarographically at three diffrent temperatures, \(pK_{D_1}\)values· have been found to be 3·63, 3·66 and 3·70 and \(pK_{D_2}\) values as 10.24, 10·18 and 10·11 at 20°,30° and 40° respectively.
R. S. Saxena, Singh, Pratap
openaire +2 more sources