Results 21 to 30 of about 167,504 (265)

Direct Potentiometric Determination of Fluoride Species by Using Ion-Selective Fluoride Electrode

open access: yesInternational Journal of Electrochemical Science, 2012
A novel approach and method for potentiometric determination of acid dissociation constant (Ka) of hydrofluoric acid are described. Proposed method is based on using commercial fluoride ISE (FISE) as very inexpensive, simple and reasonably fast method ...
Ante Prkić   +3 more
doaj   +1 more source

The solvent deuterium isotope effect on the dissociation constant of iodic acid

open access: yesCHIMIA, 1973
The solubilities of hydrated and deuterated copper(II) iodate in HClO4–H2O and DClO4–D2O solutions respectively, were measured at 1, 15, 25 and 35°C, the perchloric acid concentrations ranging from 0 to 1.0 m.
H. Gamsjäger, F. Gerber, O. Antonsen
doaj   +1 more source

Synthesis and Determination of Acid Dissociation Constants in Dimethyl Sulfoxide–Water Hydroorganic Solvent of 5,5-Diphenylpyrrolidine N-Aroylthiourea Derivatives

open access: yesJournal of the Turkish Chemical Society, Section A: Chemistry, 2017
Novel 5,5-diphenylpyrrolidineN-aroylthioureas, containing 4-methylbenzoyl, 2-chlorobenzoyl,2,4-dichlorobenzoyl, and2-naphthoyl, were synthesized and their structural analysis was performed using 1H nuclear magnetic resonance (NMR), 13C NMR, Fourier ...
Yahya Nural
doaj   +1 more source

The missing hydrogen ion, part-1: Historical precedents vs. fundamental concepts

open access: yesSports Medicine and Health Science, 2023
The purpose of this review and commentary was to provide an historical and evidence-based account of organic acids and the biochemical and organic chemistry evidence for why cells do not produce metabolites that are acids.
Robert Robergs   +3 more
doaj   +1 more source

Thermodynamic function of valineacid in n-n dimethyl formamide mixtures from conductance measurement

open access: yesمجلة بغداد للعلوم, 2013
Some physical properties enthalpy (?H), entropy (?s), free energy (?G),capacities(?cp?) and Pka values) for valine in dimethyl foramideover the temperature range 293.15-318.15K, were determined by direct conductance measurements. The acid dissociation at
Baghdad Science Journal
doaj   +1 more source

Calculating the Aqueous pKa of Phenols: Predictions for Antioxidants and Cannabinoids

open access: yesAntioxidants, 2023
We aim to develop a theoretical methodology for the accurate aqueous pKa prediction of structurally complex phenolic antioxidants and cannabinoids. In this study, five functionals (M06-2X, B3LYP, BHandHLYP, PBE0, and TPSS) and two solvent models (SMD and
Max Walton-Raaby   +3 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

The Structural Basis and Functional Consequences of Interactions Between Tetrodotoxin and Voltage-Gated Sodium Channels

open access: yesMarine Drugs, 2006
: Tetrodotoxin (TTX) is a highly specific blocker of voltage-gated sodium channels. The dissociation constant of block varies with different channel isoforms.
C. Ruben, Shana L. Geffeney
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

The dissociation constant and acid hydrolysis rate of hydroxysulfamic acid [PDF]

open access: yesCanadian Journal of Chemistry, 1989
The acid dissociation constant and hydrolysis rate of hydroxysulfamic acid (HSA) in acid aqueous solutions have been studied. The acid dissociation constant was determined to be K = 1.5 ± 0.5 M at 298 K. The hydrolysis rate, R, was found to be R = k[H+][HSA], where k = 6.2 × 1012 exp (−26 300/RT) M−1 s−1 at (μ = 1.0 M and [HSA] is the concentration of
Littlejohn, D.   +2 more
openaire   +2 more sources

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