Results 1 to 10 of about 165,907 (163)
Determination of the microscopic acid dissociation constant of piperacillin and identification of dissociated molecular forms [PDF]
For amphoteric ß-lactam antibiotics, the acid dissociation constant (pKa) is a fundamental parameter to characterize physicochemical and biochemical properties of antibiotics and to predict persistence and removal of drugs.
Guoao Li +5 more
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Hybrid micellar liquid chromatography was used for practical determination of acid dissociation constant (pKa) of three analytes, namely, ibuprofen (IBU), naproxen (NPX) and benzoic acid (BZA).
M. E. K. Wahba, D. El Sherbiny
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The acid dissociation constants of mellitic acid
The acid dissociation constants of mellitic acid were evaluated at 25 °C from potentiometric titrations in aqueous solutions of the constant Na+ molarity 3 M consisting preponderantly of NaClO4. The obtained values are summarized in the table.
Adrian Beutler, Anton Stebler
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Favipiravir Determination in Pharmaceutical Formulation via HPLC Chromatographic Approach [PDF]
Favipiravir is a broad-spectrum antiviral drug and it has increasing interest regarding its potential use in Covid-19 therapy. In the present work, a simple, fast, precise Reverse-Phase High-Performance Liquid Chromatography (RP-HPLC) technique was ...
Sabriye Aydinoglu, Metin Bozyel
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SYNTHESIS AND IDENTIFICATION OF SOME HYDROXAMIC DERIVATIVES AND STUDYING THEIR THERMO AND PHOTO DEGRADATION [PDF]
The aim of this research is to prepare and study the kinetics effect of temperature and photochemical reactions of the hydroxamic acid derivatives of diethyl succinate through the interaction of alkyl halides and diethyl succinate in the presence of ...
ISMAIL AL-KHATEEB +2 more
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The dissociation constant is an important physicochemical property of drug molecules that affects the pharmacokinetic and pharmacodynamic properties of drugs.
Wanying Wang +5 more
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Acid dissociation constants of glycopeptides [PDF]
Glycopeptides containing mainly four amino acid residues in the sequence Asn-Leu-Thr-Ser, with small amounts of additional amino acid residues, were isolated from enzymic hydrolysates of hen's-egg albumin. Heterogeneity of the carbohydrate moiety was confirmed. Acid-base titrations showed that the alpha-amino group has a pKa value of 6.43 at 25 degrees
B M, Austen, R D, Marshall
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Zinc oxide (ZnO) nanorods were coated on glass substrates and used as photocatalysts to evaluate the kinetic behavior of three different aromatic structures: i) single aromatic ring (phenol), ii) poly-aromatic ring (methylene blue), and iii) complex ...
Elie A. Daher +3 more
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Modified Stability of microRNA-Loaded Nanoparticles
microRNAs represent promising drugs to treat and prevent several diseases, such as diabetes mellitus. microRNA delivery brings many obstacles to overcome, and one strategy to bypass them is the manufacturing of self-assembled microRNA protein ...
Katja Fresacher-Scheiber +6 more
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Cytochrome c (Cc) underwent accelerated evolution from the stem of the anthropoid primates to humans. Of the 11 amino acid changes that occurred from horse Cc to human Cc, five were at Cc residues near the binding site of the Cc:CcO complex. Single-point
Sue Ellen Brand +10 more
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