Results 11 to 20 of about 458,181 (213)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Novel homologous lactate transporter improves l‑lactic acid production from glycerol in recombinant strains of Pichia pastoris [PDF]

, 2016
Background: Crude glycerol is the main byproduct of the biodiesel industry. Although it can have different applications, its purification is costly. Therefore, in this study a biotechnological route has been proposed for further utilization of crude ...
Carvalho, Lucas Silva, Castro, Virgilio H. de, Goldman, Gustavo Henrique, Lima, Pollyne Borborema Almeida de, Magalhães, Beatriz Simas, Melo, Nadiele Tamires Moreira, Menino, Gisele Soares, Mulder, Kelly Cristina Leite, Mulinari, Eduardo, Parachi, Nádia Skorupa, Reis, Thaila Fernanda dos   +10 more
core   +1 more source

The preparation of crystalline lactic acid [PDF]

, 1933
On account of its importance in intermediary metabolism, lactic acid was among the first compounds chosen in our plan, which we have described in a previous communication (1), to augment the available data on the free energies of formation of substances ...
Borsook, Henry, Huffman, Hugh M., Liu, Yun-Pu   +2 more
core  

Transcriptional response to lactic acid stress in the hybrid yeast Zygosaccharomyces parabailii [PDF]

, 2017
Lactic acid has a wide range of applications starting from its undissociated form, and its production using cell factories requires stress-tolerant microbial hosts.
Branduardi, Paola, Byrne, Kevin P., Kuanyshev, Nurzhan, Morrissey, John P., Ortiz-Merino, Raúl A., Porro, Danilo, Varela, Javier A., Wolfe, Kenneth H.   +7 more
core   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

The ring-opening polymerization of D,L-lactide in the melt initiated with tetraphenyltin [PDF]

, 1984
Melt polymerization conditions for D,L-lactide initiated with tetraphenyltin were studied with regard to polymer molecular weight and weight distributions.
Berg, J.W.A. van den, Feijen, J., Kohn, F.E., Ridder, G. van de   +3 more
core   +2 more sources

Sustainable bioplastics manufacturing from renewable sources

FEBS Open Bio, EarlyView.
Bioplastics are manufactured by using polymers from different bio‐based sources. These novel materials not only offer biodegradability but also possess various functional properties that make them suitable for diverse applications. Recent developments in the preparation of bioplastics are reported, highlighting the distinct properties of each type of ...
C. Valeria L. Giosafatto, Marika Avitabile, Michela Famiglietti, Talayeh Kordjazi, Marzieh Moosavi‐Nasab, Odile F. Restaino, Loredana Mariniello   +6 more
wiley   +1 more source

Effect of lactid acid bacteria inoculants, formic acid, potassium sorbate and sodium benzoate on fermentation quality and aerobic stability of wilted grass silage [PDF]

, 2006
The efficiency of a novel strain of lactic acid bacteria inoculant (Lactobacillus plantarum VTT E-78076, E76) on the fermentation quality of wilted silage was studied.
Haikara, Auli, Jaakkola, Seija, Jalava, Taina, Saarisalo, Eeva, Skyttä, Eija   +4 more
core   +1 more source

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source