Results 101 to 110 of about 796,985 (357)

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Structural and functional characterization of a cold-adapted stand-alone TPM domain reveals a relationship between dynamics and phosphatase activity [PDF]

, 2018
The TPM domain constitutes a family of recently characterized protein domains that are present in most living organisms. Although some progress has been made in understanding the cellular role of TPM-containing proteins, the relationship between ...
Aran, Martin, Cicero, Daniel Oscar, Ithuralde, Raúl Esteban, Pellizza, Leonardo, Smal, Clara, Turjanski, Adrian   +5 more
core   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Measurement of Acid Ecto-phosphatase Activity in Live Leishmania donovani Parasites

Bio-Protocol, 2019
Acid ecto-phosphatases are enzymes that hydrolyze phosphomonoesters in the acidic pH range with their active sites facing the extacellular medium. Their activities can be measured in living cells.
Amalia Papadaki, Haralabia Boleti
doaj   +1 more source

Electron microscopical and histochemical studies on the transverse striated muscles of birds after prolonged hypokinesis [PDF]

Studies of the gastrocnemius muscle were carried out in 4 month old cockerels of the laying hybrid after hypokinesis lasting 15 and 30 days. It was found that restricted movement resulted in dystrophic changes of myotibrils, enlargement of the ...
Belak, M., Boda, K., Kocisova, J., Marcanik, J., Skarda, R.   +4 more
core   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Acid Phosphatases and Seed Shriveling in Triticale [PDF]

, 1984
Te May Ching, D. M. Thompson, R. J. Metzger   +2 more
openalex   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Citric Acid Controls the Activity of YopH Bacterial Tyrosine Phosphatase

Drug Design, Development and Therapy
Joanna Styszko,1 Tomasz Kostrzewa,1 Magdalena Gorska-Ponikowska,1,2 Alicja Kuban-Jankowska1 1Department of Medical Chemistry, Medical University of Gdansk, Gdansk, Poland; 2Department of Biophysics, Institute of Biomaterials and Biomolecular Systems ...
Styszko J, Kostrzewa T, Gorska-Ponikowska M, Kuban-Jankowska A   +3 more
doaj  

Assessment of the microbiological activity in agricultural and urban soils

Soil Science Annual, 2014
The aim of this study was to evaluate the enzymatic soil and the number of selected microorganisms in urban soil, which are located in the lane of the reconstructed road and compare it with a soil cultivated for agricultural purposes.
DEC DOROTA
doaj   +1 more source