Results 201 to 210 of about 347,998 (329)

A century of change in the California Current: upwelling system amplifies acidification. [PDF]

Nat Commun
Stoll MMV, Deutsch CA, Jurikova H, Rae JWB, Frenzel H, Gothmann AM, Alin SR, Gagnon AC.   +7 more
europepmc   +1 more source

An Enhanced Ocean Acidification Observing Network: From People to Technology to Data Synthesis and Information Exchange [PDF]

, 2019
Bronte Tilbrook, Elizabeth B. Jewett, Michael D. DeGrandpre, José Martín Hernández‐Ayón, Richard A. Feely, D. K. Gledhill, Lina Hansson, Kirsten Isensee, Meredith Kurz, Jan Newton, Samantha Siedlecki, Fei Chai, Sam Dupont, Michelle Graco, Eva Calvo, Dana Greeley, Lydia Kapsenberg, Marine Lebrec, Carles Pelejero, Katherina L. Schoo, Maciej Telszewski   +20 more
openalex   +1 more source

Dual Targeting of Tau Kinases and Autophagy by Abemaciclib Independent of CDK4/6 Inhibition

Advanced Science, EarlyView.
Abemaciclib rescues cognitive function and attenuates tau pathology in Alzheimer's disease models, but not through its known cancer‐fighting mechanism. This study demonstrates that abemaciclib operates independently of CDK4/6 inhibition, instead directly targeting tau kinases CaMKII and GSK3β while simultaneously promoting autophagic clearance of ...
Jihui Han, June‐Hyun Jeong, Dongjoon Lee, Yujin Jung, Yujin Jin, Eun Sun Jung, Haeng Jun Kim, Woo Youn Kim, Chang‐Han Lee, Inhee Mook‐Jung   +9 more
wiley   +1 more source

Programmable self-destruction of artificial cells with death signaling. [PDF]

Chem Sci
Krehan J, Baranda Pellejero L, Walther A.   +2 more
europepmc   +1 more source

Effect of Inhibiting Vacuolar Acidification on Insulin Signaling in Hepatocytes [PDF]

, 2004
Alejandro Balbis, Gerardo Baquiran, Víctor Dumas, Barry I. Posner   +3 more
openalex   +1 more source

Metabolic Reprogramming Driven by Trophoblasts and Decidual XCR1+PMN‐MDSC Crosstalk Controls Adverse Outcomes Associated With Advanced Maternal Age

Advanced Science, EarlyView.
The interaction between trophoblasts and decidual polymorphonuclear myeloid‐derived suppressor cells (dPMN‐MDSCs) via the XCL1–XCR1 axis is crucial for fetal development during the third trimester. Disruption of this axis impairs FOXO1 activity and causes metabolic imbalance in dPMN‐MDSCs, contributing to adverse outcomes associated with advanced ...
Meiqi Chen, Yuxiong Guo, Qing Zhao, Jingping Liu, Shuyi Kuang, Zhengcong Huang, Chenlin Lv, Shuxiu Xu, Zekai Zhuang, Anyan Yang, Jing Li, Kai Wu, Yumei He   +12 more
wiley   +1 more source

Using Mathematical Modeling of Tumor Metabolism to Predict the Magnitude, Composition, and Hypoxic Interactions of Microenvironment Acidosis. [PDF]

Bioessays
Hulikova A, Swietach P.
europepmc   +1 more source

The consequences of human-driven ocean acidification for marine life [PDF]

, 2009
Scott C. Doney
openalex   +1 more source

Flipping the Switch: MeCP2‐Mediated Lactylation Rewires Microglial Metabolism and Inflammation via the HK2/mTOR Axis in Poststroke Neuroinflammation

Advanced Science, EarlyView.
Stroke‐induced lactate accumulation promotes p300‐mediated lactylation of methyl‐CpG binding protein 2 (MeCP2) at lysine 210, which reprograms microglial metabolism toward glycolysis and activates the hexokinase 2 (HK2)/mTOR axis. This cascade promotes proinflammatory responses and impairs neurofunctional outcomes.
Zengyu Zhang, Shanshan Huang, Yong Wang, Zhiwen Jiang, Zhuohang Liu, Chenran Wang, Rong Ji, Yiwen Yuan, Xueyu Mao, Kaicheng Yang, Huicong Niu, Yanqin Gao, Jing Zhao   +12 more
wiley   +1 more source

Bidirectional crosstalk between the bone extracellular matrix and lysosomes in bone remodeling and osteoporosis. [PDF]

Front Endocrinol (Lausanne)
Zhou C, Hu X, Jing Y, Zhang J, Tao J, Ouyang X, Tang J, Zhang G, Liu H.   +8 more
europepmc   +1 more source