Results 41 to 50 of about 1,955 (284)

The Effect of Acidifier-Dextrose against Hen Day Production and Feed Conversion Ratio in Laying Hens Infected with Avian Pathogenic Escherichia coli

Veterinary Medicine International, 2021
Colibacillosis in Indonesia until now still appears frequently, so the case of colibacillosis laying hens cannot reach the peak of egg production; the egg production period is delayed and easily infected with other diseases.
Sunaryo Hadi Warsito, Emy Koestanti Sabdoningrum, Nana Tripalupi, Ayu Nur Hidayati, Anwar Ma’ruf, Poedji Hastutiek, Mirni Lamid, M. Anam Al-Arif, Herry Agoes Hermadi, Oky Setyo Widodo   +9 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Efek Penambahan Acidifier Pada Pakan Bentuk Pelet Terhadap Karakteristik dan Gambaran Histomorfometri Villi Sekum Kelinci New Zealand White

Jurnal Nutrisi Ternak Tropis
Kelinci usia muda atau lepas sapih memiliki tingkat kematian yang tinggi. Tingkat kematian yang tinggi disebabkan oleh masalah pakan, gangguan dan masalah pencernaan disertai dengan kondisi mikroflora usus yang belum seimbang didalam sistem pencernaan ...
Analis Wisnu Wardhana, Dipo Aramando Lif Rizky, Heli Tistiana   +2 more
doaj   +1 more source

THE EFFECT OF ANTIBIOTICS AND ACIDIFIER TREATMENT ON THE COUNT OF LACTOBACILLUS SP., E. COLI AND CLOSTRIDIUM SP. IN THE INTESTINE OF CHICKENS [PDF]

Kafrelsheikh Veterinary Medical Journal, 2009
The effect of addition of some commonly used antibiotics and acidifieron the total bacterial count of defined intestinal microflora as Lactobacillussp., E. coli, and Clostridium sp.
H.S. Abd El-Hamid, A.M. Awad, E.A Rayhan, H.F. Ellakany   +3 more
doaj   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Profil Lemak Darah dan Kualitas Telur Ayam Sentul pada Pemberian Asam Laktat sebagai Acidifier dalam Pakan yang Mengandung Probiotik [PDF]

, 2021
Penelitian bertujuan untuk mengevaluasi efek penggunaan acidifier dalam pakan probiotik terhadap profil lemak darah (kolesterol, LDL, HDL, dan trgliserida), kualitas telur (kimia dan fisik) telur ayam sentul.
ADHIPUTRA, Mochammad Fakhri
core  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source