Results 51 to 60 of about 36,864 (262)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

LIMING EFFECT ON SOIL HEAVY METALS AVAILABILITY [PDF]

open access: yesPoljoprivreda, 2013
The aim of this paper was to determine the influence of acid soils liming and initial soil acidity as well as organic matter content on availability of four heavy metals m(Zn, Pb, Cr and Cd).
Krunoslav Karalić   +4 more
doaj  

Prediction and mastering of wine acidity and tartaric precipitations: the Mextar® software tool

open access: yesOENO One, 2002
The MEXTAR® software is a mathematical tool able to predict the physicochemical state of a wine. Solving rigorously physicochemical equilibria, including complexation ones, it enables to simulate various operations endured by a wine: tartaric ...
Audrey Devatine   +3 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Surprising acidity for the methylene of 1,3-indenocorannulenes?

open access: yesBeilstein Journal of Organic Chemistry
Quantitative assessment of the first acidity constant (pKa) for BFC (27.6 in CH3CN) and FIC (27.8 in CH3CN) shows the methylene protons to be significantly more acidic than those in related cyclopentadiene (32 in CH3CN), indene (34 in CH3CN), or fluorene
Shi Liu   +5 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Physical and Chemical Properties of Commercial Baked Milk vs. Experimental Samples

open access: yesТехника и технология пищевых производств
Ryazhenka is a popular Russian baked milk product. The physicochemical profiles of commercial, small-farm, and home-made baked milk remain fragmentary in scientific literature.
Padarozhniaya Iryna, Vetokhin Siarhei
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Solvent effect on protonation of tpps in water-DMF mixtures

open access: yesBulletin of the Chemical Society of Ethiopia, 2017
The protonation of 5,10,15,20-tetrakis(4-sulfonatophenyl)porphyrin was investigated in aqueous solutions of N,N-dimethyformamide at 25 °C and 0.1 mol.dm-3 sodium perchlorate.
A. Farajtabar, M. Faeli
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

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