Results 171 to 180 of about 430,684 (299)

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Effect of support and acidity of catalyst on the direct oxidation of ethylene to acetic acid

, 2001
The selective oxidation of ethylene to acetic acid was investigated on Pd-acid/support catalyst system. The catalytic activity is influenced strongly by the acidity of the catalyst. The stronger the catalyst acidity the higher the catalytic activity. The
Cai, TX, Bao, XH, Fang, KG, Cheng, MJ, Zhang, JL, Wang, XP   +5 more
core  

The pH-PI3K/AKT/mTORC1 axis in the survival of stem cells from the apical papilla: A critical target for rescue by microenvironment-engineered hydrogels in pulp regeneration. [PDF]

J Dent Sci
Zhang C, Cao H, Li J, Yan C, Liu Y, Zheng S, Wang X.   +6 more
europepmc   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Blue and green shade nets differentially regulate organic acid accumulation in citrus fruit. [PDF]

Front Plant Sci
Elshahat A, Liu YZ, Elatafi E, Alebidi A, Gobena AA, Liu HQ, Luo Y, Elhendawy B, Tahir R, Rehman SU, Keyhani AB, Al-Obeed RS, Abdel-Sattar M.   +12 more
europepmc   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Microbial Assessment and Sensory Acceptance of Extended Shelf Life Commercial Inflight Nasi Lemak Stored at Chill Temperature Using Acidity Regulator

In this study, the effects of acidity regulators on the shelf life, quality, and organoleptic characteristics of inflight nasi lemak were investigated. High nutritional, moisture and fat content in rice have led to some limitations to the shelf life of ...
Raja Nurul Hidayah binti Raja Norazli
core  

The ocean: a key Earth system regulator with boundaries. [PDF]

Natl Sci Rev
Mathesius S, Kaiser J, Ödalen M, Rockström J, Sakschewski B, Caesar L.   +5 more
europepmc   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Genome-wide association mapping reveals stable genomic regions associated with fruit quality traits in tomato (<i>Solanum lycopersicum</i> L.). [PDF]

Front Plant Sci
Srungarapu RS, Kandel DR, Rajkumar MS, Mandadi KK, Crosby K, Avila CA.   +5 more
europepmc   +1 more source