Results 171 to 180 of about 38,696 (225)
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Hyperphosphatemia in Lactic Acidosis
New England Journal of Medicine, 1977The initial clue to the presence of lactic acidosis is usually a physical sign such as Kussmaul breathing, a sudden change in mental status or the complex of signs associated with shock.
L R, O'Connor, K L, Klein, J E, Bethune
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Endocrinology and Metabolism Clinics of North America, 1993
Lactic acidosis is the most common metabolic acidosis. At clinical presentation, several causes usually can be identified. The liver is a major site of removal of lactate and hydrogen ions, and abnormalities in the aerobic metabolism of lactate by mitochondria in hepatocytes and other cells may contribute to many clinical conditions in which ...
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Lactic acidosis is the most common metabolic acidosis. At clinical presentation, several causes usually can be identified. The liver is a major site of removal of lactate and hydrogen ions, and abnormalities in the aerobic metabolism of lactate by mitochondria in hepatocytes and other cells may contribute to many clinical conditions in which ...
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Intensive Care Medicine, 2003
The detection of tissue hypoxia and its correction is one of the aim of the hemodynamic monitoring. Classical hemodynamic variable often fail to achieve this goal. Lactate measurements may be a good indicator of tissue hypoxia. Selected review of the articles on lactate in critically ill patients.
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The detection of tissue hypoxia and its correction is one of the aim of the hemodynamic monitoring. Classical hemodynamic variable often fail to achieve this goal. Lactate measurements may be a good indicator of tissue hypoxia. Selected review of the articles on lactate in critically ill patients.
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Clinical Chemistry and Laboratory Medicine (CCLM), 2017
Abstract Lactate is one of the most crucial intermediates in carbohydrate and nonessential amino acid metabolism. The complexity of cellular interactions and metabolism means that lactate can be considered a waste product for one cell but a useful substrate for another.
Jansen, Seheult +2 more
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Abstract Lactate is one of the most crucial intermediates in carbohydrate and nonessential amino acid metabolism. The complexity of cellular interactions and metabolism means that lactate can be considered a waste product for one cell but a useful substrate for another.
Jansen, Seheult +2 more
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Clinical Nuclear Medicine, 2017
A 39-year-old man presented with new onset of sinus congestion, shortness of breath, and diaphoresis. His laboratory tests were notable for hypercalcemia and lactic acidosis. A CT scan of the head demonstrated mild paranasal disease. CT scan of the chest, abdomen, and pelvis demonstrated omental caking with lymphadenopathy and a thickened loop of bowel
John W, McKay +2 more
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A 39-year-old man presented with new onset of sinus congestion, shortness of breath, and diaphoresis. His laboratory tests were notable for hypercalcemia and lactic acidosis. A CT scan of the head demonstrated mild paranasal disease. CT scan of the chest, abdomen, and pelvis demonstrated omental caking with lymphadenopathy and a thickened loop of bowel
John W, McKay +2 more
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Dichloroacetate and Lactic Acidosis
Annals of Internal Medicine, 1988Excerpt To the Editor:We read with interest the article by Stacpoole and associates (1) on the dichloroacetate treatment in lactic acidosis.
E L, Kinney, R J, Wright
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The Journal of Pediatrics, 1981
PRIMARY LACTIC ACIDOSIS/LACTIC ACIDURIA occurs in patients with a deficiency of specific enzymes involved in the metabolism of pyruvate, such as pyruvate carboxylase, pyruvate dehydrogenase, and phosphoenolpyruvate carboxykinase, and in other metabolic disorders such as type 1 glycogen storage disease, hereditary fructose intolerance, and disorders of ...
J G, Rogers +3 more
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PRIMARY LACTIC ACIDOSIS/LACTIC ACIDURIA occurs in patients with a deficiency of specific enzymes involved in the metabolism of pyruvate, such as pyruvate carboxylase, pyruvate dehydrogenase, and phosphoenolpyruvate carboxykinase, and in other metabolic disorders such as type 1 glycogen storage disease, hereditary fructose intolerance, and disorders of ...
J G, Rogers +3 more
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Disease-a-Month, 1989
An understanding of the pathophysiology of lactic acidosis is crucial in facilitating the optimal care of critically ill patients. The relevant biochemistry of lactic acidosis is reviewed, and the more controversial aspects relating to the genesis of the acidosis are highlighted.
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An understanding of the pathophysiology of lactic acidosis is crucial in facilitating the optimal care of critically ill patients. The relevant biochemistry of lactic acidosis is reviewed, and the more controversial aspects relating to the genesis of the acidosis are highlighted.
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Enzyme, 2017
For use in screening for disorders of pyruvate metabolism in cultured skin fibroblasts, we developed a sensitive assay method for measuring the rates of decarboxylation of (1-^14 C)-pyruvate using dichloroacetate (DCA). By this method, disorders of the mechanism of activation of pyruvate dehydrogenase (PDH) were found in 2 of 10 patients with ...
Y, Kuroda +4 more
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For use in screening for disorders of pyruvate metabolism in cultured skin fibroblasts, we developed a sensitive assay method for measuring the rates of decarboxylation of (1-^14 C)-pyruvate using dichloroacetate (DCA). By this method, disorders of the mechanism of activation of pyruvate dehydrogenase (PDH) were found in 2 of 10 patients with ...
Y, Kuroda +4 more
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Annals of Clinical Biochemistry: International Journal of Laboratory Medicine, 1989
About ten years ago, Zilva' argued that there is a fundamental difference between hydrolysis of adenosine triphosphate (ATP) under aerobic and anaerobic conditions: 'H+ produced by hydrolysis of ATp4yielded by anaerobic glycolysis is only significant because it is not used in resynthesis' (of ATP presumably).
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About ten years ago, Zilva' argued that there is a fundamental difference between hydrolysis of adenosine triphosphate (ATP) under aerobic and anaerobic conditions: 'H+ produced by hydrolysis of ATp4yielded by anaerobic glycolysis is only significant because it is not used in resynthesis' (of ATP presumably).
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