Results 181 to 190 of about 36,716 (234)
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Dichloroacetate and Lactic Acidosis
Annals of Internal Medicine, 1988Excerpt To the Editor:We read with interest the article by Stacpoole and associates (1) on the dichloroacetate treatment in lactic acidosis.
E L, Kinney, R J, Wright
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The Journal of Pediatrics, 1981
PRIMARY LACTIC ACIDOSIS/LACTIC ACIDURIA occurs in patients with a deficiency of specific enzymes involved in the metabolism of pyruvate, such as pyruvate carboxylase, pyruvate dehydrogenase, and phosphoenolpyruvate carboxykinase, and in other metabolic disorders such as type 1 glycogen storage disease, hereditary fructose intolerance, and disorders of ...
J G, Rogers +3 more
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PRIMARY LACTIC ACIDOSIS/LACTIC ACIDURIA occurs in patients with a deficiency of specific enzymes involved in the metabolism of pyruvate, such as pyruvate carboxylase, pyruvate dehydrogenase, and phosphoenolpyruvate carboxykinase, and in other metabolic disorders such as type 1 glycogen storage disease, hereditary fructose intolerance, and disorders of ...
J G, Rogers +3 more
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Disease-a-Month, 1989
An understanding of the pathophysiology of lactic acidosis is crucial in facilitating the optimal care of critically ill patients. The relevant biochemistry of lactic acidosis is reviewed, and the more controversial aspects relating to the genesis of the acidosis are highlighted.
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An understanding of the pathophysiology of lactic acidosis is crucial in facilitating the optimal care of critically ill patients. The relevant biochemistry of lactic acidosis is reviewed, and the more controversial aspects relating to the genesis of the acidosis are highlighted.
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Enzyme, 2017
For use in screening for disorders of pyruvate metabolism in cultured skin fibroblasts, we developed a sensitive assay method for measuring the rates of decarboxylation of (1-^14 C)-pyruvate using dichloroacetate (DCA). By this method, disorders of the mechanism of activation of pyruvate dehydrogenase (PDH) were found in 2 of 10 patients with ...
Y, Kuroda +4 more
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For use in screening for disorders of pyruvate metabolism in cultured skin fibroblasts, we developed a sensitive assay method for measuring the rates of decarboxylation of (1-^14 C)-pyruvate using dichloroacetate (DCA). By this method, disorders of the mechanism of activation of pyruvate dehydrogenase (PDH) were found in 2 of 10 patients with ...
Y, Kuroda +4 more
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Annals of Clinical Biochemistry: International Journal of Laboratory Medicine, 1989
About ten years ago, Zilva' argued that there is a fundamental difference between hydrolysis of adenosine triphosphate (ATP) under aerobic and anaerobic conditions: 'H+ produced by hydrolysis of ATp4yielded by anaerobic glycolysis is only significant because it is not used in resynthesis' (of ATP presumably).
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About ten years ago, Zilva' argued that there is a fundamental difference between hydrolysis of adenosine triphosphate (ATP) under aerobic and anaerobic conditions: 'H+ produced by hydrolysis of ATp4yielded by anaerobic glycolysis is only significant because it is not used in resynthesis' (of ATP presumably).
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Advances in Pediatrics, 1975
Children with chronic metabolic acidosis should be investigated to determine the presence of an organic acid, especially when the plasma electrolyte profile shows a deficiency of anion. One of the organic acids that should be looked for in such a patient is lactic acid.
S, Israels +3 more
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Children with chronic metabolic acidosis should be investigated to determine the presence of an organic acid, especially when the plasma electrolyte profile shows a deficiency of anion. One of the organic acids that should be looked for in such a patient is lactic acid.
S, Israels +3 more
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Phenformin and lactic acidosis
Clinical Pharmacology & Therapeutics, 1966There is considerable evidence, both from animal studies and clinical reports, to suggest that the hypoglycemic agent phenformin interferes with lactate metabolism. Experimental data are reported which are consistent with a defiCiency in the ability of phenformin‐treated rats to handle endogenous and exogenous lactate.
J, Lacher, L, Lasagna
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Journal of Autism and Developmental Disorders, 1985
Four patients are described who have two coexistent syndromes: the behavioral syndrome of autism and the biochemical syndrome of lactic acidosis. One of the four patients also had hyperuricemia and hyperuricosuria. These patients raise the possibility that one subgroup of the autism syndrome may be associated with inborn errors of carbohydrate ...
M, Coleman, J P, Blass
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Four patients are described who have two coexistent syndromes: the behavioral syndrome of autism and the biochemical syndrome of lactic acidosis. One of the four patients also had hyperuricemia and hyperuricosuria. These patients raise the possibility that one subgroup of the autism syndrome may be associated with inborn errors of carbohydrate ...
M, Coleman, J P, Blass
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Lactic Acidosis in the Critically Ill
Acta Clinica Belgica, 2000info:eu-repo/semantics ...
Ciarka, Agnieszka +2 more
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“Lactic acidosis in critical illness.”
Rehabilitation Oncology, 1992This article reviews the current body of knowledge regarding lactic acidosis in critically ill patients. The classification of disordered lactate metabolism and its pathogenesis are examined. The utility of lactate as a metabolic monitor of shock is examined and current therapeutic strategies in the treatment of patients suffering from lactic acidosis ...
B A, Mizock, J L, Falk
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