Results 131 to 140 of about 233,323 (358)
British Journal of Clinical Pharmacology, EarlyView.Aims This real‐world pharmacovigilance study utilizes FDA Adverse Event Reporting System (FAERS) data (2004–2024) to characterize age‐related disparities in hydroxychloroquine (HCQ)‐associated adverse events (AEs), addressing gaps in age‐stratified risk assessment. Methods Disproportionality analysis (reporting odds ratios, RORs) and parametric Weibull
Guanghan Sun +4 more
wiley +1 more source
Metformin-related lactic acidosis: Case report [Acidosis láctica por metformina: reporte de caso] [PDF]
, 2017 Lactic acidosis is defined as the presence of pH < 7.35, blood lactate> 2.0 mmol/L and PaCO2 < 42 mmHg. However, the definition of severe lactic acidosis is controversial. The primary cause of severe lactic acidosis is shock.
Jorge Samuel Cortés Román
core +1 more source
Therapeutic Targeting of Cancer Stem Cells: Integrating and Exploiting the Acidic Niche
Frontiers in Oncology, 2019 Cancer stem cells (CSC) or tumor-initiating cells represent a small subpopulation of cells within the tumor bulk that share features with somatic stem cells, such as self-renewal and pluripotency.
Catherine Vander Linden, Cyril Corbet
doaj +1 more source
Diabetes, obesity and metabolism, 2017 Metformin is renally excreted and has been associated with the development of lactic acidosis. Although current advice is to omit metformin during illnesses that may increase the risk of acute kidney injury (AKI), the evidence supporting this is lacking.
Paul J. Connelly +5 more
semanticscholar +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aims Glycogen storage disease type Ib (GSD‐Ib) is a rare genetic disorder causing neutropenia and neutrophil dysfunction in children. G‐CSF has been the primary treatment, but emerging data support the potential of empagliflozin, an SGLT2 inhibitor, as a promising investigational option.
Elizabeth Iwasyk +5 more
wiley +1 more source
Lactic acidosis following heart transplantation: a common phenomenon? [PDF]
, 2002 BACKGROUND Lactic acidosis (LAc) is a common form of metabolic acidosis early after heart transplantation (HTX). The mechanism remains unclear. This study analyzed 13 patients who developed severe LAc after HTX.
Thierry Carrel +11 more
core +1 more source
British Journal of Clinical Pharmacology, EarlyView.Abstract Aim Non‐surgical treatment of acute liver failure (ALF) is primarily supportive and depends on the underlying cause. While N‐acetylcysteine (NAC) is proven effective in paracetamol‐induced ALF, its potential benefits in non‐paracetamol ALF for paediatric patients remain unclear.
Alise D. E. de Groot +7 more
wiley +1 more source
Lactic acidosis, hyperlactatemia and sepsis [PDF]
, 2016 Among hospitalized patients, lactic acidosis represents the most common cause of metabolic acidosis. Lactate is not just a metabolic product of anaerobic glycolysis but is triggered by a variety of metabolites even before the onset of anaerobic ...
Andrea Montagnani, Roberto Nardi
core +1 more source
Frontiers in Neurology, 2019 Background: Amide proton transfer (APT) MR imaging has shown great potential in the evaluation of stroke severity because of its sensitivity to acid environments.
Lu Yu +10 more
doaj +1 more source