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Advances in Kidney Disease and Health
Metabolic acidosis is a common disorder that occurs in a variety of clinical settings. The kidney maintains acid-base homeostasis through the elimination of protons and reabsorption/generation of bicarbonate. Metabolic acidosis develops when these mechanisms are overwhelmed or impaired, in situations such as rapid production of nonvolatile acids ...
Keiko I, Greenberg, Stewart H, Lecker
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Metabolic acidosis is a common disorder that occurs in a variety of clinical settings. The kidney maintains acid-base homeostasis through the elimination of protons and reabsorption/generation of bicarbonate. Metabolic acidosis develops when these mechanisms are overwhelmed or impaired, in situations such as rapid production of nonvolatile acids ...
Keiko I, Greenberg, Stewart H, Lecker
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Annals of Emergency Medicine, 1985
Brain tissue acidosis is a result of either an increase in tissue PCO2 or an accumulation of acids produced by metabolism. Severe hypercapnia (arterial PCO2 around 300 mm Hg) may cause a fall in tissue pH to around 6.6 without any deterioration of the cerebral energy state or morphologic evidence of irreversible cell damage.
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Brain tissue acidosis is a result of either an increase in tissue PCO2 or an accumulation of acids produced by metabolism. Severe hypercapnia (arterial PCO2 around 300 mm Hg) may cause a fall in tissue pH to around 6.6 without any deterioration of the cerebral energy state or morphologic evidence of irreversible cell damage.
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