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Disease-a-Month, 1989
An understanding of the pathophysiology of lactic acidosis is crucial in facilitating the optimal care of critically ill patients. The relevant biochemistry of lactic acidosis is reviewed, and the more controversial aspects relating to the genesis of the acidosis are highlighted.
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An understanding of the pathophysiology of lactic acidosis is crucial in facilitating the optimal care of critically ill patients. The relevant biochemistry of lactic acidosis is reviewed, and the more controversial aspects relating to the genesis of the acidosis are highlighted.
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Endocrinology and Metabolism Clinics of North America, 1993
Lactic acidosis is the most common metabolic acidosis. At clinical presentation, several causes usually can be identified. The liver is a major site of removal of lactate and hydrogen ions, and abnormalities in the aerobic metabolism of lactate by mitochondria in hepatocytes and other cells may contribute to many clinical conditions in which ...
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Lactic acidosis is the most common metabolic acidosis. At clinical presentation, several causes usually can be identified. The liver is a major site of removal of lactate and hydrogen ions, and abnormalities in the aerobic metabolism of lactate by mitochondria in hepatocytes and other cells may contribute to many clinical conditions in which ...
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Advances in Kidney Disease and Health
Metabolic acidosis is a common disorder that occurs in a variety of clinical settings. The kidney maintains acid-base homeostasis through the elimination of protons and reabsorption/generation of bicarbonate. Metabolic acidosis develops when these mechanisms are overwhelmed or impaired, in situations such as rapid production of nonvolatile acids ...
Keiko I, Greenberg, Stewart H, Lecker
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Metabolic acidosis is a common disorder that occurs in a variety of clinical settings. The kidney maintains acid-base homeostasis through the elimination of protons and reabsorption/generation of bicarbonate. Metabolic acidosis develops when these mechanisms are overwhelmed or impaired, in situations such as rapid production of nonvolatile acids ...
Keiko I, Greenberg, Stewart H, Lecker
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Annals of Emergency Medicine, 1985
Brain tissue acidosis is a result of either an increase in tissue PCO2 or an accumulation of acids produced by metabolism. Severe hypercapnia (arterial PCO2 around 300 mm Hg) may cause a fall in tissue pH to around 6.6 without any deterioration of the cerebral energy state or morphologic evidence of irreversible cell damage.
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Brain tissue acidosis is a result of either an increase in tissue PCO2 or an accumulation of acids produced by metabolism. Severe hypercapnia (arterial PCO2 around 300 mm Hg) may cause a fall in tissue pH to around 6.6 without any deterioration of the cerebral energy state or morphologic evidence of irreversible cell damage.
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