Results 51 to 60 of about 134,882 (291)

Regulation of T cell antitumor immune response by tumor induced metabolic stress

Cell Stress, 2018
Adaptive T cell immune response is essential for tumor growth control. The efficacy of immune checkpoint inhibitors is regulated by intratumoral immune response. The tumor microenvironment has a major role in adaptive immune response tuning.
Fanny Chalmin, Mélanie Bruchard, Frederique Vegran, Francois Ghiringhelli   +3 more
doaj   +1 more source

3‐Hydroxyisobutyryl‐CoA hydrolase deficiency in an infant with developmental delay and high anion gap acidosis

Clinical Case Reports, 2021
Due to the rarity of this disorder, paying attention to diagnostic clues is important. Low valine formula seems to be effective in improvement of patient's symptoms. Prevention of consanguineous marriage is the best way to prevent this disease.
Hedyeh Saneifard, Asieh Mosallanejad, Aida Fallahzadeh, Ali Sheikhy   +3 more
doaj   +1 more source

Metabolic Acidosis and Subclinical Metabolic Acidosis in CKD [PDF]

Journal of the American Society of Nephrology, 2017
Metabolic acidosis is not uncommon in CKD and is linked with bone demineralization, muscle catabolism, and higher risks of CKD progression and mortality. Clinical practice guidelines recommend maintaining serum total CO2 at ≥22 mEq/L to help prevent these complications.
openaire   +3 more sources

The LDH‐H3K18La‐Nur77 Axis Potentiates Immune Escape in Small Cell Lung Cancer

Advanced Science, EarlyView.
Lactate from SCLC tumors induces H3K18 lactylation in naïve CD8+ T cells, upregulating Nurr77 and enhancing tonic TCR signaling. This leads to T cell hyporesponsiveness to stimulation, impairing antitumor immunity and reducing immunotherapy efficacy.
Xiaoling Shang, Bo Cheng, Chenyue Zhang, Chenglong Zhao, Ruiqing Wang, Xun Zhang, Dizhi Jiang, Xinyu Zhang, Xinyue Ma, Hongyuan Mao, Zerun Li, Chenhan Huang, Tianzi Wang, Kaiyue Guo, Liwen Wang, Ning Tang, Haiyong Wang   +16 more
wiley   +1 more source

Características clínicas y evolución de los pacientes con intoxicación por metanol atendidos en un hospital general.: Clinical characteristics and outcome of patients with methanol poisoning treated in a general hospital

Revista Médica Herediana, 2010
Objetivo: Describir las características clínicas y la evolución de los pacientes con intoxicación por metanol. Material y métodos: Estudio descriptivo, transversal, retrospectivo, tipo serie de casos en pacientes con diagnóstico de intoxicación por ...
Patricia E Oscanoa, Luis M Sierra, Juan Miyahira   +2 more
doaj  

In Vitro Model for Evaluation of Cancer Cell Proliferative Activity under Simulated Acidosis and Using Chitosan Microparticles

Applied Sciences, 2022
This investigation provides experimental data related to the development of a useful in vitro model allowing for a deeper analysis of invasive (metastatic) cancer cells using the effect of forced acidosis on the behavior of an epithelial colon cancer ...
Donika Ivanova, Tanya Tacheva, Severina Semkova, Radmila Panovska, Zvezdelina Yaneva   +4 more
doaj   +1 more source

Bispecific Antibody Targeting VEGF/TGF‐β Synergizes with Local Radiotherapy: Turning Tumors from Cold to Inflamed and Amplifying Abscopal Effects

Advanced Science, EarlyView.
Y332D, a bispecific antibody that simultaneously blockades VEGF and TGF‐β, counteracted negative RT effects that are attributed to the upregulation of TGF‐β and VEGF, as well as further enhanced the immunostimulatory effects of RT, thereby reprograming the TME from immune “cold” to inflamed state and forming an effective in‐situ vaccine that eradicate ...
Lijuan Lyu, Ming Yi, Ji Chen, Jing Zhang, Xiaobin Ma, Xiaojun Zhang, Liang Zeng, Yan Xue, Haimei Wen, Yujiao Deng, Pengfei Zhou, Kongming Wu, Huafeng Kang, Zhijun Dai   +13 more
wiley   +1 more source

Gitelman’s syndrome complicated by mild renal insufficiency and high anion gap acidosis; a rare presentation in a young female [PDF]

Journal of Nephropathology, 2015
Background: Gitelman’s syndrome (GS) is a rare autosomal recessive renal tubular disorder that is characterized by episodic clinical manifestations and persistent biochemical abnormalities.
Nazrul Hassan Jafry, Ejaz Ahmed, Muhammed Mubarak   +2 more
doaj   +1 more source

Glycolytic Enzyme HK2 Phosphorylates nSMase1 to Promote Astrocytic Exosomes Biogenesis Contributing to Acute Ischemic Stroke Injury

Advanced Science, EarlyView.
This study reveals that the glycolytic enzyme HK2 mediates hypoxia‐induced astrocytic exosome biogenesis by directly phosphorylating nSMase1. These astrocytic exosomes impair brain endothelial tight junctions. Astrocyte‐specific knockdown of HK2 reduces exosome release and alleviates brain injury after MCAO.
Chen Chen, YuWei Zhou, LongXiang Sheng, FangYing Mai, YuXuan Ding, ShiRan Hong, JiaXin Wu, JiaKai Pi, GuangMei Yan, YiJun Huang, JingJing Duan, Xuefeng Hua, Wei Yin   +12 more
wiley   +1 more source

Hyponatremia Associated with Prophylactic Low-Dose Trimethoprim during Systemic Corticosteroid Therapy for AQP4-Positive Optic Neuritis in a Diabetic Patient

Antibiotics, 2020
Hyponatremia associated with low-dose trimethoprim in patients on concomitant systemic corticosteroid therapy has rarely been reported. Here, we describe a 57-year-old woman with a history of diabetes mellitus and hypertension treated with telmisartan ...
Masahiro Takubo, Sho Tanaka, Masaru Kushimoto, Jin Ikeda, Katsuhiko Ogawa, Yutaka Suzuki, Masanori Abe, Hisamitsu Ishihara, Midori Fujishiro   +8 more
doaj   +1 more source