Results 41 to 50 of about 167,619 (297)

L-DOS47 Elevates Pancreatic Cancer Tumor pH and Enhances Response to Immunotherapy

Biomedicines
Acidosis is an important immunosuppressive mechanism that leads to tumor growth. Therefore, we investigated the neutralization of tumor acidity to improve immunotherapy response. L-DOS47, a new targeted urease immunoconjugate designed to neutralize tumor
Bruna Victorasso Jardim-Perassi, Pietro Irrera, Oluwaseyi E. Oluwatola, Dominique Abrahams, Veronica C. Estrella, Bryce Ordway, Samantha R. Byrne, Andrew A. Ojeda, Christopher J. Whelan, Jongphil Kim, Matthew S. Beatty, Sultan Damgaci-Erturk, Dario Livio Longo, Kim J. Gaspar, Gabrielle M. Siegers, Barbara A. Centeno, Justin Y. C. Lau, Shari A. Pilon-Thomas, Arig Ibrahim-Hashim, Robert J. Gillies   +19 more
doaj   +1 more source

Intoxicación por cianuro, perspectiva desde urgencias: reporte de dos casos y revisión de la literatura

Medicina U.P.B., 2019
Aunque poco común, la intoxicación por cianuro acarrea una mortalidad alta, sobre todo, cuando no se administra el tratamiento oportuno. La exposición a este tóxico puede darse por inhalación o por ingestión oral.
Andrés Felipe Estrada Atehortúa, Mateo Zuluaga Gómez, Marie Claire Berrouet Mejía   +2 more
doaj   +1 more source

Sodium bicarbonate to improve physical function in patients over 60 years with advanced chronic kidney disease: the BiCARB RCT

Health Technology Assessment, 2020
Background: Advanced chronic kidney disease is common in older people and is frequently accompanied by metabolic acidosis. Oral sodium bicarbonate is used to treat this acidosis, but evidence is lacking on whether or not this provides a net gain in ...
Miles D Witham, Margaret Band, Huey Chong, Peter T Donnan, Geeta Hampson, May Khei Hu, Roberta Littleford, Edmund Lamb, Philip A Kalra, Gwen Kennedy, Paul McNamee, Deirdre Plews, Petra Rauchhaus, Roy L Soiza, Deepa Sumukadas, Graham Warwick, Alison Avenell   +16 more
doaj   +1 more source

Severe Prolonged SGLT2i-induced Euglycemic Diabetic Ketoacidosis Refractory to Standard Therapy and Dialysis: Case Report and Literature Review

Oman Medical Journal, 2022
Sodium-glucose cotransporter type 2 inhibitors (SGLT2i) are oral hypoglycemic agents that have insulin-independent glucose-lowering effects mediated by increasing the renal excretion of glucose by inhibiting the SGLT2-mediated renal glucose reabsorption.
Raya Almazrouei, Fatima Alkindi, Aisha Alshamsi, Tasnim Dawoud, Ahmad Chaaban, Masood Ur Rahman   +5 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

The diagnostic accuracy of different fetal blood sample lactate cutoffs in labor, utilizing the StatStrip Xpress® lactate‐meter: A population‐based observational study

Acta Obstetricia et Gynecologica Scandinavica
Introduction A recent study recommended 5.2 mmol/L as a cutoff for fetal blood sample (FBS) lactate in labor for the StatStrip Lactate®/Lactate Xpress® lactate meter.
Magnus B. Berge, Jørg Kessler, Anne Cathrine Staff, Anne Flem Jacobsen   +3 more
doaj   +1 more source

Joint Acidosis and Acid-Sensing Receptors and Ion Channels in Osteoarthritis Pathobiology and Therapy

Cells
Osteoarthritis (OA) lacks disease-modifying therapies, in part because key features of the joint microenvironment remain underappreciated. One such feature is localized acidosis, characterized by sustained reductions in extracellular pH within the ...
William N. Martin, Colette Hyde, Adam Yung, Ryan Taffe, Bhakti Patel, Ajay Premkumar, Pallavi Bhattaram, Hicham Drissi, Nazir M. Khan   +8 more
doaj   +1 more source

Risk factors for lactic acidosis and severe hyperlactataemia in HIV-1-infected adults exposed to antiretroviral therapy.

, 2007
BACKGROUND: Severe hyperlactataemia and lactic acidosis are rare serious complications of antiretroviral therapy (ART). METHODS: Lactic acidosis was defined as pH 5 mmol/l.
Lactic Acidosis International Study Group
core   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Case report: severe ethylene glycol poisoning and the challenges in its diagnosis

Revista Médica de Minas Gerais
Introduction: Ethylene glycol (EG) is a liquid widely used throughout the world as an antifreeze. Many reports have shown accidental and intentional intoxication, and access to this alcohol is quite easy in Brazil.
Juliana Sartorelo Almeida, Adebal de Andrade Filho, Natália Dias do Nascimento, Pedro Henrique Oliveira de Paulo, Antonio José Marinho Cedrim Filho   +4 more
doaj   +1 more source