Results 41 to 50 of about 171,422 (307)

Intoxicación por cianuro, perspectiva desde urgencias: reporte de dos casos y revisión de la literatura

Medicina U.P.B., 2019
Aunque poco común, la intoxicación por cianuro acarrea una mortalidad alta, sobre todo, cuando no se administra el tratamiento oportuno. La exposición a este tóxico puede darse por inhalación o por ingestión oral.
Andrés Felipe Estrada Atehortúa, Mateo Zuluaga Gómez, Marie Claire Berrouet Mejía   +2 more
doaj   +1 more source

Sodium bicarbonate to improve physical function in patients over 60 years with advanced chronic kidney disease: the BiCARB RCT

Health Technology Assessment, 2020
Background: Advanced chronic kidney disease is common in older people and is frequently accompanied by metabolic acidosis. Oral sodium bicarbonate is used to treat this acidosis, but evidence is lacking on whether or not this provides a net gain in ...
Miles D Witham, Margaret Band, Huey Chong, Peter T Donnan, Geeta Hampson, May Khei Hu, Roberta Littleford, Edmund Lamb, Philip A Kalra, Gwen Kennedy, Paul McNamee, Deirdre Plews, Petra Rauchhaus, Roy L Soiza, Deepa Sumukadas, Graham Warwick, Alison Avenell   +16 more
doaj   +1 more source

Severe Prolonged SGLT2i-induced Euglycemic Diabetic Ketoacidosis Refractory to Standard Therapy and Dialysis: Case Report and Literature Review

Oman Medical Journal, 2022
Sodium-glucose cotransporter type 2 inhibitors (SGLT2i) are oral hypoglycemic agents that have insulin-independent glucose-lowering effects mediated by increasing the renal excretion of glucose by inhibiting the SGLT2-mediated renal glucose reabsorption.
Raya Almazrouei, Fatima Alkindi, Aisha Alshamsi, Tasnim Dawoud, Ahmad Chaaban, Masood Ur Rahman   +5 more
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Transient dilutional acidosis but no lactic acidosis upon cardiopulmonary bypass in patients undergoing coronary artery bypass grafting

, 2016
Introduction : Dilutional acidosis may result from the introduction of a large fluid volume into the patients’ systemic circulation, resulting in a considerable dilution of endogenous bicarbonate in the presence of a constant carbon dioxide partial ...
Miriam Petersen, Serhat Sönmez, Konstantinos Tsagakis, Herbert de Groot, Daniel-Sebastian Dohle, Rabea Verhaegh, Heinz Jakob, Johanna Katharina Teloh   +7 more
core   +1 more source

The diagnostic accuracy of different fetal blood sample lactate cutoffs in labor, utilizing the StatStrip Xpress® lactate‐meter: A population‐based observational study

Acta Obstetricia et Gynecologica Scandinavica
Introduction A recent study recommended 5.2 mmol/L as a cutoff for fetal blood sample (FBS) lactate in labor for the StatStrip Lactate®/Lactate Xpress® lactate meter.
Magnus B. Berge, Jørg Kessler, Anne Cathrine Staff, Anne Flem Jacobsen   +3 more
doaj   +1 more source

Joint Acidosis and Acid-Sensing Receptors and Ion Channels in Osteoarthritis Pathobiology and Therapy

Cells
Osteoarthritis (OA) lacks disease-modifying therapies, in part because key features of the joint microenvironment remain underappreciated. One such feature is localized acidosis, characterized by sustained reductions in extracellular pH within the ...
William N. Martin, Colette Hyde, Adam Yung, Ryan Taffe, Bhakti Patel, Ajay Premkumar, Pallavi Bhattaram, Hicham Drissi, Nazir M. Khan   +8 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Case report: severe ethylene glycol poisoning and the challenges in its diagnosis

Revista Médica de Minas Gerais
Introduction: Ethylene glycol (EG) is a liquid widely used throughout the world as an antifreeze. Many reports have shown accidental and intentional intoxication, and access to this alcohol is quite easy in Brazil.
Juliana Sartorelo Almeida, Adebal de Andrade Filho, Natália Dias do Nascimento, Pedro Henrique Oliveira de Paulo, Antonio José Marinho Cedrim Filho   +4 more
doaj   +1 more source

Acidose metabólica na infância: por que, quando e como tratá-la? Metabolic acidosis in childhood: why, when and how to treat

Jornal de Pediatria, 2007
OBJETIVO: Apresentar uma revisão atualizada e crítica sobre os mecanismos das principais patologias associadas e o tratamento da acidose metabólica, discutindo aspectos controversos quanto aos benefícios e riscos da utilização do bicarbonato de sódio e ...
Olberes V. B. Andrade, Flávio O. Ihara, Eduardo J. Troster   +2 more
doaj   +1 more source