Results 41 to 50 of about 153,870 (311)

Extracellular Acidosis and mTOR Inhibition Drive the Differentiation of Human Monocyte-Derived Dendritic Cells

Cell Reports, 2020
Summary: During inflammation, recruited monocytes can differentiate either into macrophages or dendritic cells (DCs); however, little is known about the environmental factors that determine this cell fate decision. Low extracellular pH is a hallmark of a
Fernando Erra Díaz, Valeria Ochoa, Antonela Merlotti, Ezequiel Dantas, Ignacio Mazzitelli, Virginia Gonzalez Polo, Juan Sabatté, Sebastián Amigorena, Elodie Segura, Jorge Geffner   +9 more
doaj   +1 more source

Survival with Good Neurological Outcome despite Prolonged Cardiopulmonary Resuscitation and Extreme Acidosis after Out-of-Hospital Cardiac Arrest Due to Acute Myocardial Infarction: A Case Report and Review of the Literature

Clinics and Practice, 2023
We report the case of a 49-year-old male who suffered from a myocardial infarction with subsequent cardiac arrest. The emergency medical team began cardiopulmonary resuscitation, including defibrillation of ventricular fibrillation.
Sylvère Störmann, Kristina Busygina, Ralph Hein-Rothweiler, Julius Steffen, Stefanie Förderreuther, Nora Salein, Matthias W. Angstwurm   +6 more
doaj   +1 more source

Intoxicación por cianuro posterior a infusión prolongada de Nitroprusiato de sodio: a propósito de un caso

Medicina U.P.B., 2023
El nitroprusiato de sodio fue aprobado desde 1974 como medicamento para las crisis hipertensivas. Desde entonces existe controversia sobre el potencial tóxico del mismo.
Manuela Castaño Velez, Marie Claire Berrouet Mejía, Mateo Zuluaga Gómez   +2 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Increased cytoplasmic and nuclear S100A6 expression is associated with improved prognosis in ovarian cancer

BMC Cancer
Background Ovarian cancer is one of the most common gynaecological cancers affecting more than 300,000 women worldwide each year. S100 calcium-binding protein A6 (S100A6) is a member of the S100 family of calcium-binding proteins.
Aruba Farooq, Evren M. Akyuz, Brandon WQ Cheah, Suha Deen, Stewart G. Martin, Mattéa J. Finelli, Sarah Storr, Alan McIntyre   +7 more
doaj   +1 more source

L-DOS47 Elevates Pancreatic Cancer Tumor pH and Enhances Response to Immunotherapy

Biomedicines
Acidosis is an important immunosuppressive mechanism that leads to tumor growth. Therefore, we investigated the neutralization of tumor acidity to improve immunotherapy response. L-DOS47, a new targeted urease immunoconjugate designed to neutralize tumor
Bruna Victorasso Jardim-Perassi, Pietro Irrera, Oluwaseyi E. Oluwatola, Dominique Abrahams, Veronica C. Estrella, Bryce Ordway, Samantha R. Byrne, Andrew A. Ojeda, Christopher J. Whelan, Jongphil Kim, Matthew S. Beatty, Sultan Damgaci-Erturk, Dario Livio Longo, Kim J. Gaspar, Gabrielle M. Siegers, Barbara A. Centeno, Justin Y. C. Lau, Shari A. Pilon-Thomas, Arig Ibrahim-Hashim, Robert J. Gillies   +19 more
doaj   +1 more source

Perspectivas atuais do tratamento da cetoacidose diabética em pediatria Current perspectives for treating children with diabetic ketoacidosis

Jornal de Pediatria, 2007
OBJETIVO: Revisar os conceitos atuais da fisiopatologia, diagnóstico e tratamento da cetoacidose diabética (CAD) na infância, assim como as medidas preventivas para evitar o edema cerebral. FONTES DOS DADOS: Os autores selecionaram artigos na MEDLINE com
Jefferson P. Piva, Mauro Czepielewski, Pedro Celiny R. Garcia, Denise Machado   +3 more
doaj   +1 more source

Characterization of acidosis in trauma patient

Journal of Emergencies, Trauma and Shock, 2020
Background: Recent data suggest that acidosis alone is not a good predictor of mortality in trauma patients. Little data are currently available regarding factors associated with survival in trauma patients presenting with acidosis.
Gregory S Corwin, Kevin W Sexton, William C Beck, John R Taylor, Avi Bhavaraju, Benjamin Davis, Mary K Kimbrough, Joseph C Jensen, Anna Privratsky, Rotnald D Robertson   +9 more
doaj   +1 more source

Distal renal tubular acidosis as a cause of osteomalacia in a patient with primary Sjögren's syndrome [PDF]

Vojnosanitetski Pregled, 2005
Background. One half of the patients with primary Sjögren’s syndrome has extraglandular manifestations, including renal involvement. The most frequent renal lesion is tubulo-interstitial nephritis, which manifests clinically as distal tubular acidosis ...
Jovelić Aleksandra, Stefanović Dušan
doaj   +1 more source

Cardiocongestive insufficiency due to vena cava thrombosis with secondary necro-exudative bronchopneumonia

Pubvet, 2021
The aim of this study was to report a case of vena cava thrombosis with secondary bronchopneumonia in a two-year-old Holsten breed cow from the municipality of Jacutinga, Rio Grande do Sul State, Brazil.
Maurijane Strapasson, Daniel Rossi, Júlia Fogilarini Moura, Juliana Franciele Ruzycki, Rodrigo Grando, Diorges Henrique Setim, Marina Menoncin Weschenfelder Rohenkohl, Mauro Antônio de Almeida, Geciane Toniazzo Backes, Daniela dos Santos de Oliveira   +9 more
doaj   +1 more source