Results 51 to 60 of about 233,323 (358)

Extracellular Acidosis and mTOR Inhibition Drive the Differentiation of Human Monocyte-Derived Dendritic Cells

Cell Reports, 2020
Summary: During inflammation, recruited monocytes can differentiate either into macrophages or dendritic cells (DCs); however, little is known about the environmental factors that determine this cell fate decision. Low extracellular pH is a hallmark of a
Fernando Erra Díaz, Valeria Ochoa, Antonela Merlotti, Ezequiel Dantas, Ignacio Mazzitelli, Virginia Gonzalez Polo, Juan Sabatté, Sebastián Amigorena, Elodie Segura, Jorge Geffner   +9 more
doaj   +1 more source

Survival with Good Neurological Outcome despite Prolonged Cardiopulmonary Resuscitation and Extreme Acidosis after Out-of-Hospital Cardiac Arrest Due to Acute Myocardial Infarction: A Case Report and Review of the Literature

Clinics and Practice, 2023
We report the case of a 49-year-old male who suffered from a myocardial infarction with subsequent cardiac arrest. The emergency medical team began cardiopulmonary resuscitation, including defibrillation of ventricular fibrillation.
Sylvère Störmann, Kristina Busygina, Ralph Hein-Rothweiler, Julius Steffen, Stefanie Förderreuther, Nora Salein, Matthias W. Angstwurm   +6 more
doaj   +1 more source

Acidosis and Cancer: from Mechanism to Neutralization

Cancer Metastasis Review, 2019
The extracellular pH of solid tumors is unequivocally acidic due to a combination of high rates of lactic acid production (a consequence of fermentative glycolytic metabolism) and poor perfusion.
Arig Ibrahim-Hashim, V. Estrella
semanticscholar   +1 more source

Intoxicación por cianuro posterior a infusión prolongada de Nitroprusiato de sodio: a propósito de un caso

Medicina U.P.B., 2023
El nitroprusiato de sodio fue aprobado desde 1974 como medicamento para las crisis hipertensivas. Desde entonces existe controversia sobre el potencial tóxico del mismo.
Manuela Castaño Velez, Marie Claire Berrouet Mejía, Mateo Zuluaga Gómez   +2 more
doaj   +1 more source

Effects of Treatment of Metabolic Acidosis in CKD: A Systematic Review and Meta-Analysis.

American Society of Nephrology. Clinical Journal, 2019
BACKGROUND AND OBJECTIVES Metabolic acidosis is associated with progression of CKD and has significant adverse effects on muscle and bone. A systematic review and meta-analysis was conducted to evaluate the benefits and risks of metabolic acidosis ...
S. Navaneethan, Jun Shao, J. Buysse, D. Bushinsky   +3 more
semanticscholar   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Episodic, transient systemic acidosis delays evolution of the malignant phenotype: Possible mechanism for cancer prevention by increased physical activity [PDF]

, 2009
Background\ud \ud The transition from premalignant to invasive tumour growth is a prolonged multistep process governed by phenotypic adaptation to changing microenvironmental selection pressures.
Smallbone, Kieran D, Smallbone, K., Maini, P. K., Robert A Gatenby, Gatenby, Robert A, Maini, Philip, Kieran Smallbone, Philip K Maini, Gatenby, R. A., Maini, PK, Maini, Philip K, Gatenby, RA, Smallbone, K   +12 more
core   +2 more sources

Increased cytoplasmic and nuclear S100A6 expression is associated with improved prognosis in ovarian cancer

BMC Cancer
Background Ovarian cancer is one of the most common gynaecological cancers affecting more than 300,000 women worldwide each year. S100 calcium-binding protein A6 (S100A6) is a member of the S100 family of calcium-binding proteins.
Aruba Farooq, Evren M. Akyuz, Brandon WQ Cheah, Suha Deen, Stewart G. Martin, Mattéa J. Finelli, Sarah Storr, Alan McIntyre   +7 more
doaj   +1 more source

L-DOS47 Elevates Pancreatic Cancer Tumor pH and Enhances Response to Immunotherapy

Biomedicines
Acidosis is an important immunosuppressive mechanism that leads to tumor growth. Therefore, we investigated the neutralization of tumor acidity to improve immunotherapy response. L-DOS47, a new targeted urease immunoconjugate designed to neutralize tumor
Bruna Victorasso Jardim-Perassi, Pietro Irrera, Oluwaseyi E. Oluwatola, Dominique Abrahams, Veronica C. Estrella, Bryce Ordway, Samantha R. Byrne, Andrew A. Ojeda, Christopher J. Whelan, Jongphil Kim, Matthew S. Beatty, Sultan Damgaci-Erturk, Dario Livio Longo, Kim J. Gaspar, Gabrielle M. Siegers, Barbara A. Centeno, Justin Y. C. Lau, Shari A. Pilon-Thomas, Arig Ibrahim-Hashim, Robert J. Gillies   +19 more
doaj   +1 more source

Perspectivas atuais do tratamento da cetoacidose diabética em pediatria Current perspectives for treating children with diabetic ketoacidosis

Jornal de Pediatria, 2007
OBJETIVO: Revisar os conceitos atuais da fisiopatologia, diagnóstico e tratamento da cetoacidose diabética (CAD) na infância, assim como as medidas preventivas para evitar o edema cerebral. FONTES DOS DADOS: Os autores selecionaram artigos na MEDLINE com
Jefferson P. Piva, Mauro Czepielewski, Pedro Celiny R. Garcia, Denise Machado   +3 more
doaj   +1 more source