Results 71 to 80 of about 233,323 (358)

Sodium bicarbonate to improve physical function in patients over 60 years with advanced chronic kidney disease: the BiCARB RCT

Health Technology Assessment, 2020
Background: Advanced chronic kidney disease is common in older people and is frequently accompanied by metabolic acidosis. Oral sodium bicarbonate is used to treat this acidosis, but evidence is lacking on whether or not this provides a net gain in ...
Miles D Witham, Margaret Band, Huey Chong, Peter T Donnan, Geeta Hampson, May Khei Hu, Roberta Littleford, Edmund Lamb, Philip A Kalra, Gwen Kennedy, Paul McNamee, Deirdre Plews, Petra Rauchhaus, Roy L Soiza, Deepa Sumukadas, Graham Warwick, Alison Avenell   +16 more
doaj   +1 more source

Severe Prolonged SGLT2i-induced Euglycemic Diabetic Ketoacidosis Refractory to Standard Therapy and Dialysis: Case Report and Literature Review

Oman Medical Journal, 2022
Sodium-glucose cotransporter type 2 inhibitors (SGLT2i) are oral hypoglycemic agents that have insulin-independent glucose-lowering effects mediated by increasing the renal excretion of glucose by inhibiting the SGLT2-mediated renal glucose reabsorption.
Raya Almazrouei, Fatima Alkindi, Aisha Alshamsi, Tasnim Dawoud, Ahmad Chaaban, Masood Ur Rahman   +5 more
doaj   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Acidosis-sensing glutamine pump SNAT2 determines amino acid levels and mammalian target of rapamycin signalling to protein synthesis in L6 muscle cells [PDF]

, 2007
Wasting of lean tissue as a consequence of metabolic acidosis is a serious problem in patients with chronic renal failure. A possible contributor is inhibition by low pH of the System A (SNAT2) transporter, which carries the amino acid L-glutamine (L-Gln)
HA Varoqui (18249130), TAPA Herbert (18249088), ZA Nasim (18249106), HA Butler (18249124), JA Brown (9852752), SA Kauser (18249127), JADA Erickson (18249133), KA Evans (16105145), AA Bevington (18249118)   +8 more
core   +2 more sources

Case report: severe ethylene glycol poisoning and the challenges in its diagnosis

Revista Médica de Minas Gerais
Introduction: Ethylene glycol (EG) is a liquid widely used throughout the world as an antifreeze. Many reports have shown accidental and intentional intoxication, and access to this alcohol is quite easy in Brazil.
Juliana Sartorelo Almeida, Adebal de Andrade Filho, Natália Dias do Nascimento, Pedro Henrique Oliveira de Paulo, Antonio José Marinho Cedrim Filho   +4 more
doaj   +1 more source

Association of Metformin Use With Risk of Lactic Acidosis Across the Range of Kidney Function: A Community-Based Cohort Study

JAMA Internal Medicine, 2018
Importance Approximately 1 million patients in the United States with type 2 diabetes mellitus and mild-to-moderate kidney disease do not receive guideline-directed therapy with metformin.
B. Lazarus, B. Lazarus, Aozhou Wu, Jung-Im Shin, Y. Sang, G. Alexander, Alex Secora, Lesley A. Inker, J. Coresh, Alex R. Chang, Morgan E. Grams   +10 more
semanticscholar   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Randomized preclinical study of machine perfusion in vascularized composite allografts

BJS (British Journal of Surgery), EarlyView., 2020
This study was designed to identify the optimum machine perfusion parameters for preservation of limbs before transplantation, and determine whether this was better than cold storage. Normothermic machine perfusion at a pressure of 70 mmHg (NMP‐70) provided superior preservation to cold storage after transplantation.
K. R. Amin, J. P. Stone, J. Kerr, A. Geraghty, L. Joseph, A. Montero‐Fernandez, J. K. Wong, J. E. Fildes   +7 more
wiley   +1 more source

Distal renal tubular acidosis developments in its diagnosis and pathophysiology [PDF]

, 2010
This thesis describes two groups of experiments, both relating to the condition of distal renal tubular acidosis (dRTA). In the first, an alternative diagnostic test of dRTA to the ‘gold standard’ short ammonium chloride (NH4Cl) test was assessed ...
Walsh, S.B.
core  

Lactic acidosis occurrence during exercises in the smoke chamber in a 53-year-old firefighter with no significant medical history [PDF]

, 2014
Lactic acidosis is a form of metabolic acidosis with a high anion gap, reduced rate of arterial blood pH under 7.35 mmol/l, and lactic acid concentration over 7 mmol/l.
Spychalska, Magdalena, Bronisz, Agata, Magdalena Spychalska, Agata Bronisz, Szafrańska, Małgorzata, Małgorzata Szafrańska   +5 more
core   +1 more source