Results 81 to 90 of about 233,323 (358)

Acidose metabólica na infância: por que, quando e como tratá-la? Metabolic acidosis in childhood: why, when and how to treat

Jornal de Pediatria, 2007
OBJETIVO: Apresentar uma revisão atualizada e crítica sobre os mecanismos das principais patologias associadas e o tratamento da acidose metabólica, discutindo aspectos controversos quanto aos benefícios e riscos da utilização do bicarbonato de sódio e ...
Olberes V. B. Andrade, Flávio O. Ihara, Eduardo J. Troster   +2 more
doaj   +1 more source

Brain fogginess, gas and bloating: a link between SIBO, probiotics and metabolic acidosis

Clinical and Translational Gastroenterology, 2018
Background: D‐lactic acidosis is characterized by brain fogginess (BF) and elevated D‐lactate and occurs in short bowel syndrome. Whether it occurs in patients with an intact gut and unexplained gas and bloating is unknown.
S. Rao, A. Rehman, Siegfried W. Yu, N. Andino   +3 more
semanticscholar   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Acidosis, but not alkalosis, affects anaerobic metabolism and performance in a 4-km time trial [PDF]

, 2017
Purpose: This study aimed to determine the effect of preexercise metabolic acidosis and alkalosis on power output (PO) and aerobic and anaerobic energy expenditure during a 4-km cycling time trial (TT).
Lima-Silva, AE, Lopes-Silva, Joao Paulo, Lima-Silva, Adriano E, ADRIANO EDUARDO LIMA-SILVA, Bertuzzi, R, Lopes-Silva, JP, GLENN K. MCCONELL, McConell, Glenn, Lima-Silva, Adriano, JOÃO PAULO LOPES-SILVA, Correia-Oliveira, Carlos, Bertuzzi, Romulo, DAVID JOHN BISHOP, Kiss, Maria, Correia-Oliveira, CR, CARLOS RAFAELL CORREIA-OLIVEIRA, ROMULO BERTUZZI, Lopes-Silva, João, Bishop, David, Correia-Oliveira, Carlos Rafaell, Kiss, MAPDM, MARIA AUGUSTA PEDUTI DAL’MOLIN KISS   +21 more
core   +1 more source

Lung ultrasound score versus HACOR score as a predictor for weaning outcome in patients at high risk for extubation failure

Lung India
Background: Pulmonary complications from mechanical ventilation are a significant concern in intensive care. Reducing the duration of respiratory support is vital to minimize these risks.
M Rathish, M.K Renuka, NVSN Prasant, Baby Sailaja   +3 more
doaj   +1 more source

Recurrent Hypothermia and Autonomic Dysfunction Secondary to Shapiro Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT A 44‐year‐old man presented with recurrent hypothermia, diaphoresis and hypertension. Extensive investigation for infectious, inflammatory, metabolic and endocrine aetiologies was negative. MR scan of the brain demonstrated no lesions but revealed callosal dysgenesis, consistent with Shapiro syndrome.
Naveen Kumar, Jeremy Johnson, Susanne Watkins, Eoin Mulroy   +3 more
wiley   +1 more source

Diagnosis and management of metabolic acidosis: guidelines from a French expert panel

Annals of Intensive Care, 2019
Metabolic acidosis is a disorder frequently encountered in emergency medicine and intensive care medicine. As literature has been enriched with new data concerning the management of metabolic acidosis, the French Intensive Care Society (Société de ...
B. Jung, Mikaël Martinez, Y. Claessens, M. Darmon, K. Klouche, A. Lautrette, J. Levraut, É. Maury, M. Oberlin, N. Terzi, D. Viglino, Y. Yordanov, P. Claret, N. Bigé   +13 more
semanticscholar   +1 more source

Drug-induced metabolic acidosis [PDF]

, 2017
Summary: Drug causes of metabolic acidosis are numerous and their mechanisms are diverse. Broadly, they can cause metabolic acidosis with either a normal anion gap (e.g. drug-induced renal tubular acidosis) or an elevated anion gap (e.g.
Christopher T. Holt, Hitchings, AW, Andrew W. Hitchings, Holt, CT   +3 more
core   +1 more source

Acidosis and proteolysis in the tumor microenvironment

Cancer Metastasis Review, 2019
The glycolytic phenotype of the Warburg effect is associated with acidification of the tumor microenvironment. In this review, we describe how acidification of the tumor microenvironment may increase the invasive and degradative phenotype of cancer cells.
K. Ji, Linda Mayernik, K. Moin, Bonnie F. Sloane   +3 more
semanticscholar   +1 more source