Results 81 to 90 of about 153,870 (311)

Thiamine Therapy During Refractory Lactic Acidosis in Critically Ill Children [PDF]

Introduction: Thiamin deficiency, which is an overlooked but important cause of lactic acidosis, can lead to several clinical symptoms, including neuropathy, cardiogenic shock, and death, even though it can be easily treated in critically ill children ...
Burak Balaban, Hacer Uçmak, Hasan Özen, Tanıl Kendirli, Fevzi Kahveci, Mert Kaan Coşkun, İlker Fındık, Anar Gurbanov, Merve Havan   +8 more
core   +1 more source

Does oral sodium bicarbonate therapy improve function and quality of life in older patients with chronic kidney disease and low-grade acidosis (the BiCARB trial)? : Study protocol for a randomized controlled trial [PDF]

, 2015
Date of acceptance: 01/07/2015 © 2015 Witham et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and ...
McMurdo, Marion E. T., Sumukadas, Deepa, Ogston, Simon A., Band, Margaret M., Hampson, Geeta, Edmund J. Lamb, Paul McNamee, Deepa Sumukadas, McNamee, Paul, Simon A. Ogston, Lamb, Edmund J., Witham, Miles D., Alison Avenell, null null, Margaret M. Band, Soiza, Roy L., Roy L. Soiza, Geeta Hampson, Roberta C. Littleford, Avenell, Alison, Miles D. Witham, Marion E. T. McMurdo, BiCARB Study Group, Littleford, Roberta C.   +23 more
core   +1 more source

Understanding and Overcoming Antibody‐Drug Conjugate Resistance: Biological Mechanisms and Emerging Analytical Frameworks in Breast Cancer

Advanced Science, EarlyView.
Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley   +1 more source

Randomized preclinical study of machine perfusion in vascularized composite allografts

BJS (British Journal of Surgery), EarlyView., 2020
This study was designed to identify the optimum machine perfusion parameters for preservation of limbs before transplantation, and determine whether this was better than cold storage. Normothermic machine perfusion at a pressure of 70 mmHg (NMP‐70) provided superior preservation to cold storage after transplantation.
K. R. Amin, J. P. Stone, J. Kerr, A. Geraghty, L. Joseph, A. Montero‐Fernandez, J. K. Wong, J. E. Fildes   +7 more
wiley   +1 more source

Fatal Mucormycosis Post COVID-19 Infection in Uncontrolled Diabetes with Misuse of Glucocorticoids and Antibiotics

Infection and Drug Resistance, 2022
Heba Hamed,1 Raed Madia,2 Hosniyeh Ladadweh,2 Hiba Falana,2 Abdallah Damin AbuKhalil2 1Palestine Medical Complex, Ministry of Health, Ramallah, Palestine; 2Pharmacy Department, Faculty of Pharmacy, Nursing and Health Professions, Birzeit University ...
Hamed H, Madia R, Ladadweh H, Falana H, AbuKhalil AD   +4 more
doaj  

Episodic, transient systemic acidosis delays evolution of the malignant phenotype: Possible mechanism for cancer prevention by increased physical activity

, 2009
Background\ud \ud The transition from premalignant to invasive tumour growth is a prolonged multistep process governed by phenotypic adaptation to changing microenvironmental selection pressures.
Smallbone, Kieran D, Smallbone, K., Maini, P. K., Robert A Gatenby, Gatenby, Robert A, Maini, Philip, Kieran Smallbone, Philip K Maini, Gatenby, R. A., Maini, PK, Maini, Philip K, Gatenby, RA, Smallbone, K   +12 more
core   +1 more source

Dual‐Responsive Dynamic Covalent Bond‐Based Assembly of Lipid‐Nanozyme Systems via Multi‐Target Synergy and Efficient Target Enrichment for Ischemic Stroke Therapy

Advanced Science, EarlyView.
This system adopts a biomimetic phospholipid structure, covalently binding iNOS inhibitors, neuroprotective agent PCA and vitamin E derivatives through pH/ROS dual‐responsive bonds, and assembles them with Prussian blue nanozyme to form PBB@AHA. It can efficiently penetrate the blood‐brain barrier and simultaneously release multiple active components ...
Mengcheng Guo, Qingran Guan, Guanyu Qiao, Lixue Zhang, Man Liu, Zhen Li, Qingbiao Yang, Meili Shen, Linlin Liu, Yapeng Li   +9 more
wiley   +1 more source

Associations of severe hyperlactataemia and lactic acidosis in HIV-infected patients receiving antiretroviral theraphy

, 2007
Includes bibliographical references (leaves 67-70).Severe symptomatic hyperlactataemia and lactic acidosis (SHLA) are life-threatening events that are occurring at increasing incidence levels in South Africa.
Osler, Meg
core  

Pharmacist review prevents evolving metformin-associated lactic acidosis

, 2014
What is known\ud \ud There is controversy surrounding the risk of metformin and the development of lactic acidosis. There have been no reports of a pharmacist preventing a patient developing metformin-associated lactic acidosis.\ud \ud Objectives\ud \ud ...
Naunton, M., Owoka, F., Nauton-Boom, K., Kyle, G.   +3 more
core   +1 more source

Leveraging Macrophage Metabolic Reprogramming for Enhanced Anti‐Tumor Immunity

Advanced Science, EarlyView.
Tumor‐associated macrophages (TAMs) are key regulators of the tumor microenvironment (TME), with their metabolic states playing a critical role in tumor progression or regression. This review summarizes current understanding of TAM metabolic plasticity alongside cutting‐edge bioengineering innovations, outlining a roadmap for transforming the ...
Zhiyun Liu, Lingyao Zeng, Xulin Gan, Yilin Zhou, Han Shen, Dan Wu, Xin Shou, Minmin Jiang, Liyun Shi   +8 more
wiley   +1 more source