Results 91 to 100 of about 2,829,556 (263)

Influence of mineralogy on the preservation of amino acids under simulated Mars conditions [PDF]

open access: yes, 2016
publisher: Elsevier articletitle: Influence of mineralogy on the preservation of amino acids under simulated Mars conditions journaltitle: Icarus articlelink: http://dx.doi.org/10.1016/j.icarus.2016.05.029 content_type: article copyright: © 2016 The ...
dos Santos R   +11 more
core   +1 more source

Propriedades relacionadas à acidez e basicidade a partir da abordagem em química computacional

open access: yesQuímica Nova, 2014
Analytical Chemistry books lack a clear link between thermodynamic and equilibrium approaches involving acids and bases. In this work, theoretical calculations were performed to search for these relations.
Sérgio R. B. Silva   +2 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

open access: yesFEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt   +8 more
wiley   +1 more source

Nutritive value of tomatillo fruit (Physalis ixocarpa Brot.)

open access: yesActa Societatis Botanicorum Poloniae, 2014
Tomatillo is widely cultivated in Mexico but is little known in other countries. The chemical composition of fruit from field grown plants was investigated during several vegetative seasons. Tomatillo contained a relatively high percentage of dry matter (
Joanna Ostrzycka   +4 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

Perfil de ácidos grasos en pacientes oncológicos pediátricos Plasma fatty acids profile in paediatric cancer patients

open access: yesNutrición Hospitalaria, 2012
El reducido número de casos de cáncer en la edad pediátrica y las dificultades para la investigación, han contribuido a que existan escasos estudios sobre el estado metabólico y nutricional de estos pacientes.
M.ª J. de la Torre Aguilar   +4 more
doaj  

Endogenous Ribonucleases: Therapeutic Targeting of the Transcriptome Through Oligonucleotide-Triggered RNA Inactivation

open access: yesBiomolecules
The selective regulation of gene expression at the RNA level represents a rapidly evolving field offering substantial clinical potential. This review examines the molecular mechanisms of intracellular enzymatic systems that utilize single-stranded ...
Daria A. Chiglintseva   +2 more
doaj   +1 more source

Effect of Steric Constraint at the γ-Backbone Position on the Conformations and Hybridization Properties of PNAs

open access: yesJournal of Nucleic Acids, 2011
Conformationally preorganized peptide nucleic acids (PNAs) have been synthesized through backbone modifications at the γ-position, where R = alanine, valine, isoleucine, and phenylalanine side chains. The effects of these side-chains on the conformations
Matthew J. Crawford   +4 more
doaj   +1 more source

Comparison of Salivary pH, Buffering Capacity and Alkaline Phosphatase in Smokers and Healthy Non-Smokers : Retrospective cohort study

open access: yesSultan Qaboos University Medical Journal, 2016
Objectives: Saliva contains alkaline phosphatase (ALP)—a key intracellular enzyme related to destructive processes and cellular damage—and has buffering capacity (BC) against acids due to the presence of bicarbonate and phosphate ions.
Fatemeh Ahmadi-Motamayel   +3 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

open access: yesFEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

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