Pharmacokinetic Analysis of Intravenous Push Cefepime in Critically Ill Patients With Sepsis
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 46, Issue 6, June 2026.ABSTRACT Background Intravenous push (IVP) administration of cefepime increases ease of preparation and limits the need for small volume parenterals. The data on IVP pharmacokinetic/pharmacodynamic (PK/PD) parameters are limited, but may be especially relevant in critically ill patients with altered PK/PD for time‐dependent antibiotics like cefepime ...
Susan E. Smith +8 more
wiley +1 more source
Structural Analysis and Inhibitor Modeling of Bacterioferritin From Brucella abortus
Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 6, Page 1170-1181, June 2026.ABSTRACT Iron homeostasis in various pathogenic bacteria is regulated by bacterioferritins (Bfr) which function to store Fe3+ and release Fe2+ as needed for metabolic processes. The Bfr structure consists of 18 kDa subunits in which dimer pairs bind a heme molecule and are assembled into a highly symmetrical 24‐meric spherical structure with an ...
Lijun Liu +9 more
wiley +1 more source
Active Chlorine Antiseptics in Wound Care: Recent Advances and Perspectives for Military Medicine
APMIS, Volume 134, Issue 6, June 2026.ABSTRACT The spread of multidrug‐resistant microorganisms remains a major global challenge that continues to worsen. Modern military conflicts intensify this problem by forcing healthcare systems to manage large numbers of patients with complex, heavily contaminated injuries in resource‐limited settings.
Bohdan Murashevych +3 more
wiley +1 more source
Biosynthesis, Structure, and Antibiotic Properties of Gelatinamin A, a Triculamin‐Like Lasso Peptide
ChemBioChem, Volume 27, Issue 10, 27 May 2026.Biosynthesis of the class V lasso peptide gelatinamin A was elucidated by heterologous expression of the gel biosynthetic gene cluster in Bacillus subtilis. Its 3D structure was determined by NMR, and tailoring enzymes GelT and GelP were fully reconstituted in vitro.
Tiziana Svenningsen +9 more
wiley +1 more source
Nature CommunicationsAcinetobacter baumannii is the causative agent of a wide range of nosocomial and community-acquired infections that remain extremely difficult to treat due largely to its antibiotic resistance contributed, in part, by biofilm formation.
Chongbing Liao +10 more
doaj +1 more source
ChemMedChem, Volume 21, Issue 9, 14 May 2026.Combining enhanced permeability strategies with (2‐pyridyl)methylene substitution in the sulbactam scaffold led to a novel β‐lactamase inhibitor to combat β‐lactamase‐mediated resistance to β‐lactam antibiotics. The studies presented highlight the potential of compound 3 as a next‐generation β‐lactamase inhibitor for combating infections caused by ...
Diana Rodríguez +4 more
wiley +1 more source
Role of the AmvAR efflux system on the pathogenesis of Acinetobacter baumannii. [PDF]
Sci RepGaona M +8 more
europepmc +1 more source
New Insights into <i>Acinetobacter baumannii</i> Pathogenesis and Therapeutic Implications. [PDF]
PathogensMorena R +5 more
europepmc +1 more source
Characterizing the in vitro and in vivo effect of bicarbonate on azithromycin activity against Acinetobacter baumannii. [PDF]
PLoS OneJaramillo H +8 more
europepmc +1 more source
Sulbactam-Durlobactam in the Treatment of Multidrug-Resistant <i>Acinetobacter baumannii:</i> A Narrative Review. [PDF]
Antibiotics (Basel)Viscardi S +3 more
europepmc +1 more source