Results 121 to 130 of about 100,585 (295)

The mazEF toxin-antitoxin system as a novel antibacterial target in Acinetobacter baumannii [PDF]

, 2014
Although analysis of toxin-antitoxin (TA) systems can be instructive, to date, there is no information on the prevalence and identity of TA systems based on a large panel of Acinetobacter baumannii clinical isolates.
Ghafourian, S, Good, L, Hamat, R A, Neela, V, Sadeghifard, N, Sekawi, Z, Soheili, S   +6 more
core   +5 more sources

Impregnation of Melaleuca Family Essential Oil Nanoemulsions into Pectin:Polyvinyl Alcohol Patches to Provide an Antibacterial Environment for Infected Wounds

ChemistryOpen, EarlyView.
This study reports the fabrication, characterization, and biological evaluation of bioactive patches made from pectin:polyvinyl alcohol with tea tree and niaouli oil nanoemulsions via solvent evaporation. The patches are flexible, transparent, adhesive, and absorbent. They are biocompatible and show long‐term antimicrobial activity against E.
Didem Demir, Seda Ceylan, Semih Latif İpek, Deren Aslan, Veli Özbolat   +4 more
wiley   +1 more source

Glycoproteomics and Its Role in Understanding Bacterial O‐Linked Glycosylation

PROTEOMICS, EarlyView.
ABSTRACT Protein glycosylation is now recognized as a ubiquitous process observed in all domains of life. Within bacterial species, carbohydrates can be attached to multiple residues with glycosylation of serine, threonine, or tyrosine residues via their hydroxyl side chains referred to as O‐linked glycosylation.
Kristian I. Karlic, Hamza Tahir, Nichollas E. Scott   +2 more
wiley   +1 more source

Investigating the impact of poverty on colonization and infection with drug-resistant organisms in humans: a systematic review [PDF]

, 2018
Background Poverty increases the risk of contracting infectious diseases and therefore exposure to antibiotics. Yet there is lacking evidence on the relationship between income and non-income dimensions of poverty and antimicrobial resistance ...
B Cohen, B Nolan, B Rosen, BM Isaac, BO Nomamiukor, C Costelloe, C Curtis, C García-Rey, C Kristiansson, D Moher, DM Young, DO Duerink, E Brunner, E Castro-Sánchez, E Castro-Sánchez, E Gebeyehu, E Mangrio, ES Lestari, F Barah, FM Chen, G Alvarez-Uria, HK Parsons, IN Okeke, J O'Neill, JC Seidman, JC Semenza, JLF Antunes, JP Bagger, JR Covvey, KM McMullen, L Boyanova, M Karanikolos, M Kempf, M Marmot, MA Trecker, MB Planta, MG Baker, O Henig, P Chatterjee, P Nilsson, PJ Hotez, R Kumar, R Mehdinapah, S Bratu, S Jourdain, S Willems, SJ Eells, SS Huang, TB Souza, TP Van Boeckel, United Nations Development Programme (UNDP)   +50 more
core   +2 more sources

Nanoparticle‐Based Tetracycline Delivery Systems: Advancing Therapeutic Effectiveness and Tackling Antibiotic Resistance

Particle &Particle Systems Characterization, EarlyView.
This review explores improved tetracycline (TCN) delivery via polymer‐based nanocarriers to enhance solubility, stability, and targeted release. It also covers stimuli‐responsive systems, triggered by pH, enzymes, or reactive oxygen species (ROS), and co‐delivery approaches that increase therapeutic efficacy in cancer and inflammatory diseases ...
Mahsa Molaei Nasr, Mehrab Pourmadadi, Fatemeh Yazdian, Hamid Rashedi, Abbas Rahdar, M. Ali Aboudzadeh   +5 more
wiley   +1 more source

Moving From Point‐Based Analysis to Systems‐Based Modeling: Knowledge Integration to Address Antimicrobial Resistance

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Optimizing antibiotic therapy requires a holistic bench‐to‐bedside approach with interdisciplinary collaboration between pharmacologists, clinicians, microbiologists, and computational scientists. Novel experimental models provide insights into drug‐pathogen interactions within complex host environments, while multiomics data provide details ...
Bhavatharini Arun, Gauri G. Rao
wiley   +1 more source

Regulation of overexpressed efflux pump encoding genes by cinnamon oil and trimethoprim to abolish carbapenem-resistant Acinetobacter baumannii clinical strains

BMC Microbiology
Resistance mechanisms are a shelter for Acinetobacter baumannii to adapt to our environment which causes difficulty for the infections to be treated and WHO declares this organism on the top of pathogens priority for new drug development. The most common
Neveen M. Saleh, Hadeer Ezzat, Gharieb S. El-Sayyad, Hamdallah Zedan   +3 more
doaj   +1 more source

Epidemiology of intensive care unit-acquired sepsis in Italy: results of the SPIN-UTI network [PDF]

, 2018
BACKGROUND: Sepsis is the major cause of mortality from any infectious disease worldwide. Sepsis may be the result of a healthcare associated infection (HAI): the most frequent adverse events during care delivery especially in Intensive Care Units ...
Agodi A, Arrigoni C, Auxilia F, Barchitta M, Brusaferro S, D'Errico MM, Fabiani L, Laurenti P, Mattaliano AR, Montagna MT, Mura I, Orsi GB, Pasquarella C, Squeri R, Tardivo S, Torregrossa MV   +15 more
core   +1 more source

From Membrane Composition to Antimicrobial Strategies: Experimental and Computational Approaches to AMP Design and Selectivity

Small, EarlyView.
Antimicrobial peptides (AMPs) are promising candidates for next‐generation antibiotics, acting through mechanisms such as membrane disruption and intracellular targeting. This review examines how variations in bacterial membrane composition critically influence AMP activity.
Paolo Rossetti, Marius F.W. Trollmann, Christina Wichmann, Thomas Gutsmann, Christian Eggeling, Rainer A. Böckmann   +5 more
wiley   +1 more source

The clinical characteristics of Acinetobacter bacteremia differ among genomospecies: A hospital-based retrospective comparative analysis of genotypically identified strains

Journal of Microbiology, Immunology and Infection, 2019
Background/purpose: Acinetobacter is an aerobic, gram-negative coccobacillus, which causes nosocomial infections including bacteremia. Recent development of molecular techniques has made classification of the Acinetobacter genomospecies possible, but ...
Yusuke Koizumi, Daisuke Sakanashi, Tomoko Ohno, Atsuko Yamada, Arufumi Shiota, Hideo Kato, Mao Hagihara, Hiroki Watanabe, Nobuhiro Asai, Masaya Watarai, Kenta Murotani, Yuka Yamagishi, Hiroyuki Suematsu, Hiroshige Mikamo   +13 more
doaj   +1 more source