Results 81 to 90 of about 159,303 (377)

Aspectos epidemiológicos de Acinetobacter baumannii e avaliação do perfil de resistência em amostras biológicas de pacientes atendidos em um hospital oncológico em Belém-PA

RevSALUS, 2021
Introdução: A espécie Acinetobacter baumannii, dentro de seu gênero, é a mais importante para vigilância epidemiológica por estar associada, em humanos, a diferentes tipos de infecções.
Larissa Cristina Rebelo de Souza, Nilson Veloso Bezerra, Eliane Leite da Trindade   +2 more
doaj   +1 more source

Safety and efficacy of colistin versus meropenem in the empirical treatment of ventilator-associated pneumonia as part of a macro-project funded by the Seventh Framework Program of the European Commission studying off-patent antibiotics. study protocol for a randomized controlled trial [PDF]

, 2015
Background: Ventilator-associated pneumonia (VAP) is one of the most common and severe hospital-adquired infections, and multidrugresistant gram-negative bacilli (MDR-GNB) constitute the main etiology in many countries.
Clara Rosso, Fernández, DE BLASI, Roberto Alberto, George, Dimopoulos, José Garnacho, Montero, José Miguel, Cisneros, Massimo, Antonelli, The MagicBullet study, Group   +6 more
core   +1 more source

Capsule carbohydrate structure determines virulence in Acinetobacter baumannii

PLoS Pathogens, 2021
Acinetobacter baumannii is a highly antibiotic-resistant bacterial pathogen for which novel therapeutic approaches are needed. Unfortunately, the drivers of virulence in A. baumannii remain uncertain. By comparing genomes among a panel of A.
Y. Talyansky, T. Nielsen, Jun Yan, Ulrike Carlino-Macdonald, Gisela Di Venanzio, S. Chakravorty, Amber Ulhaq, M. Feldman, T. Russo, Evgeny Vinogradov, Brian M. Luna, M. Wright, M. Adams, B. Spellberg   +13 more
semanticscholar   +1 more source

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

FEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli, Enrico Landi, Francesco Maiurano, Irene Paris, Rosanna Papa, Marco Artini, Laura Selan, Stefano Borocci, Francesco Buonocore, Esther Imperlini   +9 more
wiley   +1 more source

Outer membrane protein A (OmpA) as a potential therapeutic target for Acinetobacter baumannii infection

Journal of Biomedical Sciences, 2020
Acinetobacter baumannii (A. baumannii) is an important opportunistic pathogen causing serious nosocomial infections, which is considered as the most threatening Gram-negative bacteria (GNB).
D. Nie, Yue Hu, Zhou Chen, Mingkai Li, Z. Hou, Xiaoxing Luo, X. Mao, X. Xue   +7 more
semanticscholar   +1 more source

Bio‐Responsive Hydrogel for Targeted on‐Demand Release of a Phage Cocktail for Treatment of Pseudomonas aeruginosa Infection

Advanced Functional Materials, EarlyView.
This study presents an injectable hydrogel that responds to Pseudomonas aeruginosa infection by releasing a dual‐phage cocktail on demand. The system degrades selectively in infected wounds, enhances phage localization and stability, and shows potent antibiofilm activity and biocompatibility in an ex vivo human skin model—offering a promising strategy ...
Siyuan Tao, Anna Hu, Elnaz Bavel, Chien‐Hsun Yu, Sixuan Zhang, Vera Maria Kissling, Zhihao Li, Thomas Fintan Moriaty, Katharina Maniura‐Weber, Qun Ren   +9 more
wiley   +1 more source

A respiratory Streptococcus strain inhibits Acinetobacter baumannii from causing inflammatory damage through ferroptosis

BMC Microbiology
Background Microecological equilibrium is essential for human health. Previous research has demonstrated that Streptococcus strain A, the main bacterial group in the respiratory tract, can suppress harmful microbes and protect the body.
Ye Sun, Shuyin Li, Yuchen Che, Hao Liang, Yi Guo, Chunling Xiao   +5 more
doaj   +1 more source

Prevalence of Extensively and Pan-drug-resistant Acinetobacter spp. in Nosocomial Infections in Western Saudi Arabia

Journal of Pure and Applied Microbiology
Multidrug resistance patterns of Acinetobacter spp. have led to their emergence as an important source of nosocomial infections. This study investigated the prevalence and clinical characteristics of Acinetobacter spp.
Hanan S. Al-Ghamdi, Hesham A. Malak, Leena A. Neyaz, Najla A. Obaid, Shmoukh Alghuraibi, Mawadah M.S. AlKashkary, Khaled Elbanna, Iqbal Ahmad, Hussein H. Abulreesh   +8 more
doaj   +1 more source

The response to desiccation in <i>Acinetobacter baumannii</i>. [PDF]

Virulence
The long-term resistance to desiccation on abiotic surfaces is a key determinant of the adaptive success of Acinetobacter baumannii as a healthcare-associated bacterial pathogen. Here, the cellular and molecular mechanisms enabling A. baumannii to resist desiccation and persist on abiotic surfaces were investigated. Experiments were set up to mimic the
Lucidi M, Capecchi G, Spagnoli C, Basile A, Artuso I, Persichetti L, Fardelli E, Capellini G, Visaggio D, Imperi F, Rampioni G, Leoni L, Visca P.   +12 more
europepmc   +5 more sources

Host‐Directed Biomaterials for Combatting Bloodstream Infections: From Macrocyclic Peptides to Immune‐Activating Cell Backpacks

Advanced Functional Materials, EarlyView.
Bloodstream infections (BSI) are one of the leading causes of mortality and morbidity in both civilian and military populations. This paper summarizes recent progress in novel treatment strategies to manage BSI arising from both bacterial and fungal pathogens using molecules, particles, and materials to elicit host‐directed immunity.
Thomas Thomou, Jagadish Krishnappa, Justin B. Schaal, Prasad Tongaonkar, Dat Q. Tran, Wenchao Gu, Yung‐Fu Chang, Michael E. Selsted, Shaoyi Jiang, Samir Mitragotri, Michael Super, Christopher J. Bettinger   +11 more
wiley   +1 more source