Results 71 to 80 of about 103,755 (281)

A rational strategy to optimize photodrugs by Molecular Dynamics simulations for killing drug‐resistant Gram‐negative bacteria

AIChE Journal, EarlyView.
Abstract Antimicrobial resistance has become a major threat to human health, particularly for Gram‐negative bacteria such as Acinetobacter baumannii and Klebsiella pneumoniae. Disruption of membrane integrity is regarded as a promising antimicrobial strategy that does not induce distinct drug resistance, while increasing the internalization of drug ...
Lei Hao, Yeonho Song, Cheng Zhang, Yumei Wang, Haoying Ge, Wen Sun, Jingyun Wang, Jun Soo Kim, Xiaojun Peng, Juyoung Yoon, Haidong Li   +10 more
wiley   +1 more source

Decoding the Pathophysiology of Autoimmune Diseases—Mechanism, Triggers, and Nanotherapeutics: A Review

Advanced NanoBiomed Research, EarlyView.
This review highlights how autoimmune diseases arise from intertwined immunological, genetic, and environmental factors, emphasizing gut microbiota dysbiosis as a pivotal driver. It outlines emerging nanotechnology‐based strategies—such as liposomes, hydrogels, and polymeric nanoparticles—that enhance targeted drug delivery, minimize systemic toxicity,
Md. Meraj Ansari, Yunhui Min, Eun‐Ju Ko, Doyoung Kwon, Rehan Khan, Young‐Ok Son   +5 more
wiley   +1 more source

Vesicle-Mediated Dendritic Cell Activation in Acinetobacter baumannii Clinical Isolate, which Contributes to Th2 Response

Journal of Immunology Research, 2019
Acinetobacter baumannii, as a nonfermentation Gram-negative bacterium, mainly cause nosocomial infections in critically ill patients. With the widespread of multidrug-resistant Acinetobacter baumannii, the urgency of developing effective therapy options ...
Wei Cai, Dinesh Kumar Kesavan, Jianjun Cheng, Aparna Vasudevan, Huixuan Wang, Jie Wan, Mohamed Hamed Abdelaziz, Zhaoliang Su, Shengjun Wang, Huaxi Xu   +9 more
doaj   +1 more source

Efficacy of intravenous tigecycline in patients with Acinetobacter complex infections: results from 14 Phase III and Phase IV clinical trials

Infection and Drug Resistance, 2017
Hal Tucker, Michele Wible, Ashesh Gandhi, Alvaro QuintanaPfizer Inc, Collegeville, PA, USABackground: Acinetobacter infections, especially multidrug-resistant (MDR) Acinetobacter infections, are a global health problem.
Tucker H, Wible M, Gandhi A, Quintana A
doaj  

Effective elimination of Staphylococcal contamination from hospital surfaces by a bacteriophage-probiotic sanitation strategy: a monocentric study. [PDF]

, 2019
Persistent contamination of hospital surfaces and antimicrobial resistance (AMR) are recognized major causes of healthcare-associated infections (HAI). We recently showed that a probiotic-based sanitation (PCHS) can stably decrease surface pathogens and ...
BISI, Matteo, CASELLI, Elisabetta, D'ACCOLTI, Maria, LANZONI, Luca, MAZZACANE, Sante, SOFFRITTI, IRENE, VOLTA, Antonella   +6 more
core   +1 more source

Successful treatment of prosthetic joint infection with multidrug-resistant Acinetobacter species with debridement and retention: a case report

Sri Lankan Journal of Infectious Diseases, 2016
Acinetobacter spp. is mainly addressed in the entity of healthcare associated infections. The organism has developed substantial antimicrobial resistance, making treatment of infections attributed to A. baumannii more difficult to manage.
RND De Silva, SK Jayatilleke, A Perera
doaj   +1 more source

Whole-Genome Sequence of a European Clone II and OXA-72-Producing Acinetobacter baumannii Strain from Serbia. [PDF]

, 2015
We report here the draft genome sequence of a carbapenem-resistant Acinetobacter baumannii strain isolated from a patient, a strain which previously stayed in Serbia. This isolate possessed the blaOXA-72 carbapenemase gene.
Bernabeu, S, Bonnin, RA, Dortet, L, Fortineau, N, Girlich, D, Imanci, D, Naas, T   +6 more
core   +1 more source

Impact of COVID‐19 Pandemic on Antibiotic Resistance Patterns of Common Bacterial Pathogens to Antibiotics in Northern Ghana

Journal of Clinical Laboratory Analysis, EarlyView.
This retrospective study analyzed and compared antimicrobial resistance patterns of common bacterial pathogens before (October 2018–March 2020) and during (April 2020–December 2022) the COVID‐19 pandemic in Ghana's Northern Region. Amoxiclav (p = 0.027), ceftazidime (p = 0.002), ciprofloxacin (p = 0.001), gentamycin (p = 0.035), and meropenem (p < 0 ...
Hisham Alhassan Osumanu, Oliver Nangkuu Deberu, Abass Abdul‐Karim, Ahmed Alhassan, Ebenezer Kojo Addae, Stephen Opoku Afriyie, Stebleson Azure, Sadia Alimatu Lawal, Daron Davies Agboyie, Valentine Cheba Koyiri, Hudu Yakubu, Enoch Weikem Weyori, Kennedy Mensah Osei, Benjamin Demah Nuertey, Godfred Acheampong   +14 more
wiley   +1 more source

Bacterial Biofilm and its Clinical Implications [PDF]

, 2018
Microbial biofilm created huge burden in treatment of both community and hospital infections. A biofilm is complex communities of bacteria attached to a surface or interface enclosed in an exopolysaccharide matrix and protected from unfavorable ...
Shakibaie, Prof
core  

Emerging importance of multidrug-resistant Acinetobacter species and Stenotrophomonas maltophilia as pathogens in seriously ill patients: Geographic patterns, epidemiological features, and trends in the SENTRY Antimicrobial Surveillance Program (1997-1999) [PDF]

, 2001
As part of the SENTRY Antimicrobial Surveillance Program, a total of 1078 Acinetobacter species and 842 Stenotrophomonas maltophilia isolates were collected between January 1997 and December 1999 from 5 geographic regions (Canada, the United States ...
Forward, K. R., Gales, Ana Cristina [UNIFESP], Jones, R. N., Linares, J., Sader, Helio Silva [UNIFESP], Verhoef, J.   +5 more
core   +1 more source