Results 1 to 10 of about 65 (61)
Frontiers in Immunology, 2022 Chemokines exert crucial roles in inducing immune responses through ligation to their canonical receptors. Besides these receptors, there are other atypical chemokine receptors (ACKR1–4) that can bind to a wide range of chemokines and carry out various ...
Farhad Jadidi-Niaragh +2 more
exaly +3 more sources
Phosphoproteomic mapping of CCR5 and ACKR2 signaling properties
Frontiers in Molecular Biosciences, 2022 ACKR2 is an atypical chemokine receptor which is structurally uncoupled from G proteins and is unable to activate signaling pathways used by conventional chemokine receptors to promote cell migration.
Alessandro Vacchini +2 more
exaly +3 more sources
Vaccines, 2020 The atypical chemokine receptor ACKR2, formerly named D6, is a scavenger chemokine receptor with a non-redundant role in the control of inflammation and immunity. The scavenging activity of ACKR2 depends on its trafficking properties, which require actin
Alessandro Vacchini +2 more
exaly +3 more sources
ACKR2 in hematopoietic precursors as a checkpoint of neutrophil release and anti-metastatic activity
Nature Communications, 2018 The atypical chemokine receptor ACKR2 regulates immune responses. Here the authors confirm that ACKR2 depletion promotes primary tumor growth but show it has an anti-metastatic effect in mouse models of breast cancer by affecting myeloid differentiation ...
Matteo Massara +2 more
exaly +2 more sources
The atypical chemokine receptor-2 fine-tunes the immune response in herpes stromal keratitis
Frontiers in Immunology, 2022 Herpes stromal keratitis (HSK) is a blinding corneal disease caused by herpes simplex virus-1 (HSV-1), a common pathogen infecting most of the world’s population.
Tian Yu +9 more
doaj +1 more source
Cutaneous lesions in psoriatic arthritis are enriched in chemokine transcriptomic pathways
Arthritis Research & Therapy, 2023 Objectives Skin from people with psoriasis has been extensively studied and is assumed to be identical to skin from those with psoriatic arthritis (PsA).
Hanna Johnsson +4 more
doaj +1 more source
Evaluation of Atypical Chemokine Receptor Expression in T Cell Subsets
Cells, 2022 Chemokines are molecules that pertain to a family of small cytokines and can generate cell chemotaxis through the interaction with their receptors.
Messias Oliveira Pacheco +3 more
doaj +1 more source
Decoy Receptors Regulation by Resveratrol in Lipopolysaccharide-Activated Microglia
Cells, 2023 Resveratrol is a polyphenol that acts as antioxidants do, protecting the body against diseases, such as diabetes, cancer, heart disease, and neurodegenerative disorders, such as Alzheimer’s (AD) and Parkinson’s diseases (PD).
Rosa Calvello +5 more
doaj +1 more source
Frontiers in Immunology, 2023 Atypical chemokine receptors (ACKRs) form a small subfamily of receptors (ACKR1–4) unable to trigger G protein-dependent signaling in response to their ligands.
Martyna Szpakowska +10 more
doaj +1 more source
Placental chemokine compartmentalisation: A novel mammalian molecular control mechanism.
PLoS Biology, 2019 Atypical chemokine receptor 2 (ACKR2) is a chemokine-scavenging receptor. ACKR2-/-embryos display a reduction in size of a novel, to our knowledge, embryonic skin macrophage population referred to as 'intermediate' cells. CC chemokine receptor 2 (CCR2)-/-
Kit Ming Lee +7 more
doaj +1 more source