Results 41 to 50 of about 1,289 (149)

CCRL2 Expression by Specialized Lung Capillary Endothelial Cells Controls NK-cell Homing in Lung Cancer [PDF]

, 2023
Patterns of receptors for chemotactic factors regulate the homing of leukocytes to tissues. Here we report that the CCRL2/chemerin/CMKLR1 axis represents a selective pathway for the homing of natural killer (NK) cells to the lung.
Bernardini G., Bianchetto-Aguilera F. M., Bonecchi R., Bosisio D., Bottazzi B., Del Prete A., Garofalo S., Gismondi A., Laffranchi M., Leone R., Limatola C., Mantovani A., Parmentier M., Russo E., Salvi V., Schioppa T., Sciume G., Sozio F., Sozzani S., Tamassia N., Tiberio L.   +20 more
core   +1 more source

Spread of Psoriasiform Inflammation to Remote Tissues Is Restricted by the Atypical Chemokine Receptor ACKR2 [PDF]

Journal of Investigative Dermatology, 2017
Elucidating the poorly defined mechanisms by which inflammatory lesions are spatially restricted in vivo is of critical importance in understanding skin disease. Chemokines are the principal regulators of leukocyte migration and are essential in the initiation and maintenance of inflammation.
Shams, K, Wilson, GJ, Singh, M, Van den Bogaard, EH, Le Brocq, ML, Holmes, S, Schalkwijk, J, Burden, AD, McKimmie, CS, Graham, GJ   +9 more
openaire   +7 more sources

CCL2: An important cytokine in normal and pathological pregnancies: A review

Frontiers in Immunology, 2023
C-C motif ligand 2 (CCL2), also known as monocytic chemotactic protein 1 (MCP-1), is an integral chemotactic factor which recruits macrophages for the immune response.
Zhi Lin, Zhi Lin, Jia-Lu Shi, Min Chen, Zi-Meng Zheng, Ming-Qing Li, Ming-Qing Li, Ming-Qing Li, Ming-Qing Li, Jun Shao, Jun Shao   +10 more
doaj   +1 more source

The Extended N-Terminal Domain Confers Atypical Chemokine Receptor Properties to CXCR3-B

Frontiers in Immunology, 2022
The chemokine receptor CXCR3 plays a critical role in immune cell recruitment and activation. CXCR3 exists as two main isoforms, CXCR3-A and CXCR3-B, resulting from alternative splicing.
Giulia D’Uonnolo, Giulia D’Uonnolo, Nathan Reynders, Nathan Reynders, Max Meyrath, Dayana Abboud, Tomasz Uchański, Toon Laeremans, Brian F. Volkman, Bassam Janji, Julien Hanson, Julien Hanson, Martyna Szpakowska, Martyna Szpakowska, Andy Chevigné   +14 more
doaj   +1 more source

Chemokine receptors coordinately regulate macrophage dynamics and mammary gland development [PDF]

, 2020
Macrophages are key regulators of developmental processes, including those involved in mammary gland development. We previously demonstrated that the atypical chemokine receptor, ACKR2, contributes to control of ductal epithelial branching in the ...
Fukuoka, Ayumi, Graham, Gerard J., Hayes, Alan J., Kim, Jiwon, Love, Samantha R., Pingen, Marieke, Wilson, Gillian J.   +6 more
core   +1 more source

A guide to chemokines and their receptors [PDF]

, 2018
The chemokines (or chemotactic cytokines) are a large family of small, secreted proteins that signal through cell surface G‐protein coupled heptahelical chemokine receptors.
Braun A, Dyer DP, Garton KJ, Gupta SK, Hundelshausen P, Janssens R, Murphy PM, Sozzani S, Speck RF, Suan D, Woollard SM, Zheng Y   +11 more
core   +1 more source

Biphasic Expression of Atypical Chemokine Receptor (ACKR) 2 and ACKR4 in Colorectal Neoplasms in Association with Histopathological Findings

Biomolecules, 2020
Facilitating resolution of inflammation using atypical chemokine receptors (ACKR) as an anticancer strategy is considered but requires a deeper understanding of receptor role in carcinogenesis.
Paulina Lewandowska, Jaroslaw Wierzbicki, Marek Zawadzki, Anil Agrawal, Małgorzata Krzystek-Korpacka   +4 more
doaj   +1 more source

Extended repertoire of CXC chemokines acting as agonists and antagonists of the human and murine atypical chemokine receptor ACKR2. [PDF]

J Leukoc Biol
Abstract Atypical chemokine receptors are a subfamily of important regulators of chemokine functions. Among them, ACKR2 has long been considered a scavenger of multiple inflammatory chemokines exclusively from the CC family. Recently, we demonstrated the ability of ACKR2 to scavenge the CXC chemokine CXCL10, previously reported to bind ...
Luís R, Volkman BF, Szpakowska M, Chevigné A.   +3 more
europepmc   +3 more sources

Functional characterization of a short peptidoglycan recognition protein from Chinese giant salamander (Andrias davidianus) [PDF]

, 2017
This work was supported by the National Natural Science Foundation of China (Grant no. 31302221, 31172408 and 31272666) and Jiangsu Province (Grant no.
Chang, Mingxian, Nie, Pin, Qi, Zhitao, Qiao, Guo, Ren, Shisi, Wang, Zisheng, Xu, Qiaoqing, Zhang, Qihuan, Zou, Jun   +8 more
core   +1 more source

Distinct Differentiation Programs Triggered by IL-6 And LPS in Teleost IgM+ B Cells in the Absence of Germinal Centers [PDF]

, 2016
We would like to thank Lucia Gonzalez and Maria Sanz for technical assistance. Professor Øystein Evensen is also acknowledged for providing us with the inactivated IPNV.
Abós, Beatriz, Barreda, Daniel R., Castro, Rosario, Granja, Aitor G., Havixbeck, Jeffrey, Leal, Esther, Luque, Alfonso, Secombes, Chris J., Tafalla, Carolina, Wang, Tiehui   +9 more
core   +1 more source