A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis [PDF]
Annals of the Rheumatic Diseases, 2011 BackgroundRheumatoid arthritis (RA) can be divided into two major subsets based on the presence or absence of antibodies to citrullinated peptide antigens (ACPA).
Leonid Padyukov +2 more
exaly +2 more sources
ACPA decreases non-small cell lung cancer line growth through Akt/PI3K and JNK pathways in vitro
Cell Death and Disease, 2021 Therapeutic agents used for non-small cell lung cancer (NSCLC) have limited curative efficacy and may trigger serious adverse effects. Cannabinoid ligands exert antiproliferative effect and induce apoptosis on numerous epithelial cancers.
Ozge Boyacioglu +2 more
exaly +2 more sources
ACPA-negative RA consists of two genetically distinct subsets based on RF positivity in Japanese. [PDF]
PLoS ONE, 2012 HLA-DRB1, especially the shared epitope (SE), is strongly associated with rheumatoid arthritis (RA). However, recent studies have shown that SE is at most weakly associated with RA without anti-citrullinated peptide/protein antibody (ACPA).
Chikashi Terao +20 more
doaj +6 more sources
European Journal of Immunology, 2018 Autoreactive B cells have a central role in the pathogenesis of rheumatoid arthritis (RA), and recent findings have proposed that anti-citrullinated protein autoantibodies (ACPA) may be directly pathogenic.
Khaled Amara +2 more
exaly +4 more sources
Integrative multi-omic profiling in blood reveals distinct immune and metabolic signatures between ACPA-negative and ACPA-positive rheumatoid arthritis [PDF]
Frontiers in ImmunologyObjectiveTo investigate whether patients with ACPA-negative (ACPA–) and ACPA-positive (ACPA+) rheumatoid arthritis (RA) exhibit distinct immune and metabolic profiles in blood, using integrative proteomic and metabolomic analyses.
Benjamin Hur +16 more
doaj +2 more sources
Frontiers in Immunology, 2019 Rheumatoid arthritis (RA) associated anti-citrullinated protein autoantibodies (ACPA) target a wide range of modified proteins. Citrullination occurs during physiological processes such as apoptosis, yet little is known about the interaction of ACPA with
Gustaf Wigerblad +2 more
exaly +3 more sources
Serum test for secretory component-containing anti-citrullinated protein antibodies as a novel prognostic tool in rheumatoid arthritis at-risk subjects [PDF]
Journal of Translational AutoimmunityIndividuals with autoantibodies against citrullinated proteins (ACPA) and musculoskeletal symptoms face increased risk of developing rheumatoid arthritis (RA).
Klara Martinsson +6 more
doaj +2 more sources
The bidirectional effect of prelimbic 5-hydroxytryptamine type-4 (5-HT4) receptors on ACPA-mediated aversive memory impairment in adult male Sprague-Dawley rats [PDF]
Iranian Journal of Basic Medical Sciences, 2021 Objective(s): This study aimed at investigating the effect of serotonergic 5-HT4 receptor agonist/antagonist on memory consolidation deficit induced by ACPA (a potent, selective CB1 cannabinoid receptor agonist) in the pre-limbic (PL) cortex.
Nargol Ahmadi-Mahmoodabadi +3 more
doaj +1 more source
ACPA-Induced ATP release and K+ efflux trigger NLRP3 inflammasome activation in rheumatoid arthritis [PDF]
Cell Communication and SignalingObjectives Anti-citrullinated protein antibodies (ACPA) is one of the key inducers of the initiation and maintenance of the immune-inflammatory response in Rheumatoid arthritis (RA), yet evidence is lacking on how ACPA drives the inflammatory response ...
Li Cai +9 more
doaj +2 more sources
Exploring the landscape of aesthetic pharmacy practice
Exploratory Research in Clinical and Social Pharmacy, 2023 Background: As pharmacy practice evolves, an increasing number of pharmacists are diversifying into non-traditional roles such as aesthetic procedures.
Kamal Alhallak
doaj +1 more source