Results 11 to 20 of about 8,833 (185)

Clinical features of ACPA-negative and ACPA-positive variants of rheumatoid arthritis

Научно-практическая ревматология, 2023
The aim of the study was to study the features of the clinical picture of the disease in patients with ACPA-negative and ACPA-positive variants of rheumatoid arthritis.Materials and methods.
D. A. Dibrov, A. S. Avdeeva, V. V. Rybakova, N. V. Demidova, E. L. Nasonov   +4 more
doaj   +3 more sources

Forefoot inflammation in recent-onset ACPA-positive and ACPA-negative RA: clinically similar, but different in underlying inflamed tissues

RMD Open
Objectives Although joint swelling is traditionally interpreted as synovitis, recent imaging studies showed that there is also inflammation of tenosynovium and intermetatarsal bursae in the forefoot.
Annette H.M. van der Helm - van Mil, Dennis A. Ton, Bastiaan T. van Dijk, Hanna W. van Steenbergen   +3 more
doaj   +5 more sources

Characterization of Autoantigens Targeted by Anti-Citrullinated Protein Antibodies In Vivo: Prominent Role for Epitopes Derived from Histone 4 Proteins. [PDF]

PLoS ONE, 2016
Anti-citrullinated protein antibodies (ACPA) have become an integral part of the clinical definition of rheumatoid arthritis, and are hypothesized to be important in the immunopathogenesis of this autoimmune disease.
Xiaobo Meng, Peyman Ezzati, Irene Smolik, Charles N Bernstein, Carol Ann Hitchon, Hani S El-Gabalawy   +5 more
doaj   +1 more source

The ACPA IgM fine specificity differs from the ACPA IgG antigen-recognition profile [PDF]

Annals of the Rheumatic Diseases, 2012
Background The antigen-recognition pattern of immunoglobulin M (IgM) could, in case directed against protein-antigens, provide an indication of the antigenic moieties triggering new B cells. The half-life of IgM is short and memory B cells against T cell dependent protein antigens, typically produce IgG and not IgM antibodies.
Willemze, A., Suwannalai, P., Toorn, L. van, Stoeken-Rijsbergen, G., Levarht, E.W.N., Drijfhout, J.W., Huizinga, T.W.J., Toes, R.E.M., Trouw, L.A.   +8 more
openaire   +2 more sources

Immunoprofiling of early, untreated rheumatoid arthritis using mass cytometry reveals an activated basophil subset inversely linked to ACPA status

Arthritis Research & Therapy, 2021
Background Autoantibody production is a hallmark of rheumatoid arthritis (RA). Anti-citrullinated protein antibodies (ACPA) are highly disease-specific, and their presence is associated with more severe disease and poor prognosis compared to ACPA ...
H. Koppejan, M. Hameetman, G. Beyrend, V. van Unen, J. C. Kwekkeboom, A. H. van der Helm-van Mil, R. E. M. Toes, F. A. van Gaalen   +7 more
doaj   +1 more source

Anti-Citrullinated Peptide Antibody Expression and Its Association with Clinical Features and Outcomes in Patients with Antineutrophil Cytoplasmic Antibody-Associated Vasculitis

Medicina, 2022
Background and objectives: Anti-citrullinated peptide antibody (ACPA), a characteristic antibody detected in rheumatoid arthritis, could be linked to antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) via the formation of neutrophil ...
Sung Soo Ahn, Jung Yoon Pyo, Jasong Jungsik Song, Yong-Beom Park, Sang-Won Lee   +4 more
doaj   +1 more source

The effect of the cannabinoid CB1 receptor agonist arachidonylcyclopropylamide (ACPA) on behavioural sensitisation to methamphetamine in mice

Veterinární Medicína, 2014
The psychostimulant methamphetamine (Met), similarly to other drugs of abuse, is known to produce an increased behavioural response after its repeated application (behavioural sensitisation).
L. Landa, K. Slais, A. Machalova, A. Sulcova   +3 more
doaj   +1 more source

ACPA-negative RA consists of two genetically distinct subsets based on RF positivity in Japanese. [PDF]

PLoS ONE, 2012
HLA-DRB1, especially the shared epitope (SE), is strongly associated with rheumatoid arthritis (RA). However, recent studies have shown that SE is at most weakly associated with RA without anti-citrullinated peptide/protein antibody (ACPA).
Chikashi Terao, Koichiro Ohmura, Katsunori Ikari, Yuta Kochi, Etsuko Maruya, Masaki Katayama, Kimiko Yurugi, Kota Shimada, Akira Murasawa, Shigeru Honjo, Kiyoshi Takasugi, Keitaro Matsuo, Kazuo Tajima, Akari Suzuki, Kazuhiko Yamamoto, Shigeki Momohara, Hisashi Yamanaka, Ryo Yamada, Hiroo Saji, Fumihiko Matsuda, Tsuneyo Mimori   +20 more
doaj   +1 more source

How RA Associated HLA-DR Molecules Contribute to the Development of Antibodies to Citrullinated Proteins: The Hapten Carrier Model

Frontiers in Immunology, 2022
The risk to develop ACPA positive rheumatoid arthritis (RA), the most destructive type of autoimmune arthritis, is carried by HLA-DRB1 alleles containing a 5 amino acid motif: the shared epitope (SE).
Jean Roudier, Jean Roudier, Jean Roudier, Nathalie Balandraud, Nathalie Balandraud, Isabelle Auger, Isabelle Auger   +6 more
doaj   +1 more source

The extensive glycosylation of the ACPA variable domain observed for ACPA-IgG is absent from ACPA-IgM

Annals of the Rheumatic Diseases, 2018
Recently, we described the presence of highly sialylated N -linked glycans in the antigen-binding fragment (Fab) of almost all anti-citrullinated protein antibody (ACPA) IgG molecules.1 2 These glycans could not be found on several other autoantibody systems analysed.
Kempers, Ayla C.; Hafkenscheid, Lise; Dorjee, Annemarie L.; Moutousidou, Eleni; van de Bovenkamp, Fleur S.; Rispens, Theo; Trouw, Leendert A.; van Oosterhout, Maikel; Huizinga, Tom W. J.; Toes, Rene; Scherer, Hans Ulrich   +11 more
openaire   +6 more sources