Results 11 to 20 of about 5,038 (172)

Patients with ACPA-positive and ACPA-negative rheumatoid arthritis show different serological autoantibody repertoires and autoantibody associations with disease activity

Scientific Reports, 2023
Patients with rheumatoid arthritis (RA) can test either positive or negative for circulating anti-citrullinated protein antibodies (ACPA) and are thereby categorized as ACPA-positive (ACPA+) or ACPA-negative (ACPA−), respectively. In this study, we aimed
Kevin Y. Cunningham, Benjamin Hur, Vinod K. Gupta, Courtney A. Arment, Kerry A. Wright, Thomas G. Mason, Lynne S. Peterson, Delamo I. Bekele, Daniel E. Schaffer, Marissa L. Bailey, Kara E. Delger, Cynthia S. Crowson, Elena Myasoedova, Hu Zeng, Moses Rodriguez, Cornelia M. Weyand, John M. Davis, Jaeyun Sung   +17 more
doaj   +2 more sources

CCR6+ Th cell populations distinguish ACPA positive from ACPA negative rheumatoid arthritis [PDF]

Arthritis Research & Therapy, 2015
Patients with rheumatoid arthritis (RA) can be separated into two major subpopulations based on the absence or presence of serum anti-citrullinated protein antibodies (ACPAs). The more severe disease course in ACPA(+) RA and differences in treatment outcome between these subpopulations suggest that ACPA(+) and ACPA(-) RA are different disease subsets ...
Paulissen, Sandra M.J., van Hamburg, Jan Piet, Davelaar, Nadine, Vroman, Heleen, Hazes, Johanna M.W., de Jong, Pascal H.P., Lubberts, Erik   +6 more
core   +7 more sources

The prevalence of ACPA is lower in rheumatoid arthritis patients with an older age of onset but the composition of the ACPA response appears identical [PDF]

Arthritis Research & Therapy, 2017
Background Rheumatoid arthritis (RA) consists of two syndromes, one autoantibody-positive and one autoantibody-negative. Existing data on the relation between age of onset and prevalence of autoantibodies were conflicting.
Debbie M. Boeters, Lukas Mangnus, Sofia Ajeganova, Elisabet Lindqvist, Björn Svensson, René E. M. Toes, Leendert A. Trouw, Tom W. J. Huizinga, Francis Berenbaum, Jacques Morel, Solbritt Rantapää-Dahlqvist, Annette H. M. van der Helm-van Mil   +11 more
doaj   +2 more sources

ACPA-negative RA consists of two genetically distinct subsets based on RF positivity in Japanese. [PDF]

PLoS ONE, 2012
HLA-DRB1, especially the shared epitope (SE), is strongly associated with rheumatoid arthritis (RA). However, recent studies have shown that SE is at most weakly associated with RA without anti-citrullinated peptide/protein antibody (ACPA).
Chikashi Terao, Koichiro Ohmura, Katsunori Ikari, Yuta Kochi, Etsuko Maruya, Masaki Katayama, Kimiko Yurugi, Kota Shimada, Akira Murasawa, Shigeru Honjo, Kiyoshi Takasugi, Keitaro Matsuo, Kazuo Tajima, Akari Suzuki, Kazuhiko Yamamoto, Shigeki Momohara, Hisashi Yamanaka, Ryo Yamada, Hiroo Saji, Fumihiko Matsuda, Tsuneyo Mimori   +20 more
doaj   +3 more sources

Patients with obesity have more inflamed joints and higher CRP levels during the disease course in ACPA-positive RA but not in ACPA-negative RA [PDF]

Arthritis Research & Therapy
Background Obese RA patients have higher disease activity scores (DAS). Previous research showed that obese RA patients have higher tender joint count (TJC) and VAS general health.
N. K. den Hollander, A. M. P Boeren, A. H. M. van der Helm-van Mil, H. W. van Steenbergen   +3 more
doaj   +2 more sources

ACPA-negative and ACPA-positive RA patients achieving disease resolution demonstrate distinct patterns of MRI-detected joint-inflammation [PDF]

, 2022
Objectives Although sustained DMARD-free remission (SDFR; sustained absence of clinical-synovitis after DMARD-discontinuation) is increasingly achievable in RA, prevalence differs between ACPA-negative (40%) and ACPA-positive RA (5-10%).
Verstappen, M., Huizinga, T.W.J., Connolly, S.E., Helm-van Mil, A.H.M. van der, Matthijssen, X.M.E., Maldonado, M.A.   +5 more
core   +1 more source

Fluctuation in anti-cyclic citrullinated protein antibody level predicts relapse from remission in rheumatoid arthritis: KURAMA cohort

Arthritis Research & Therapy, 2020
Background The positivity of anti-citrullinated protein/peptide antibodies (ACPAs) is a clinically useful diagnostic and prognostic marker in rheumatoid arthritis (RA). However, the significance of ACPA titer and its fluctuation remain unclear.
Koichi Murata, Hiromu Ito, Motomu Hashimoto, Kosaku Murakami, Ryu Watanabe, Masao Tanaka, Wataru Yamamoto, Shuichi Matsuda   +7 more
doaj   +1 more source

Early intensive treatment normalises excess mortality in ACPA-negative RA but not in ACPA-positive RA [PDF]

Annals of the Rheumatic Diseases, 2020
With great interest, we read the recently published report by Poppelaars et al in which no excess mortality was observed in 155 patients with rheumatoid arthritis (RA) from the COmbinatie therapie Bij Rheumatoide Artritis (COBRA)-trial, who received early intensive treatment, compared with the general population (Standardised mortality rate (SMR) 0.80 (
Matthijssen, X.M.E., Huizinga, T.W.J., Niemantsverdriet, E., Helm-van Mil, A.H.M. van der   +3 more
openaire   +4 more sources

Characterization of Autoantigens Targeted by Anti-Citrullinated Protein Antibodies In Vivo: Prominent Role for Epitopes Derived from Histone 4 Proteins. [PDF]

PLoS ONE, 2016
Anti-citrullinated protein antibodies (ACPA) have become an integral part of the clinical definition of rheumatoid arthritis, and are hypothesized to be important in the immunopathogenesis of this autoimmune disease.
Xiaobo Meng, Peyman Ezzati, Irene Smolik, Charles N Bernstein, Carol Ann Hitchon, Hani S El-Gabalawy   +5 more
doaj   +1 more source

The ACPA IgM fine specificity differs from the ACPA IgG antigen-recognition profile [PDF]

Annals of the Rheumatic Diseases, 2012
Background The antigen-recognition pattern of immunoglobulin M (IgM) could, in case directed against protein-antigens, provide an indication of the antigenic moieties triggering new B cells. The half-life of IgM is short and memory B cells against T cell dependent protein antigens, typically produce IgG and not IgM antibodies.
Willemze, A., Suwannalai, P., Toorn, L. van, Stoeken-Rijsbergen, G., Levarht, E.W.N., Drijfhout, J.W., Huizinga, T.W.J., Toes, R.E.M., Trouw, L.A.   +8 more
openaire   +2 more sources