Clinical features of ACPA-negative and ACPA-positive variants of rheumatoid arthritis [PDF]
Научно-практическая ревматология, 2023 The aim of the study was to study the features of the clinical picture of the disease in patients with ACPA-negative and ACPA-positive variants of rheumatoid arthritis.Materials and methods.
D. A. Dibrov +4 more
doaj +4 more sources
Forefoot inflammation in recent-onset ACPA-positive and ACPA-negative RA: clinically similar, but different in underlying inflamed tissues [PDF]
RMD OpenObjectives Although joint swelling is traditionally interpreted as synovitis, recent imaging studies showed that there is also inflammation of tenosynovium and intermetatarsal bursae in the forefoot.
Annette H.M. van der Helm - van Mil +3 more
doaj +6 more sources
ACPA-negative rheumatoid arthritis: From immune mechanisms to clinical translation
EBioMedicine, 2022 Summary: The presence of anti-citrullinated protein autoantibodies (ACPA) is a hallmark feature of rheumatoid arthritis (RA), which causes chronic joint destruction and systemic inflammation.
Lidan Zhao, Xuan Zhang, Yudong Liu
exaly +3 more sources
ACPA Status Correlates with Differential Immune Profile in Patients with Rheumatoid Arthritis
Cells, 2021 Rheumatoid arthritis (RA) is a progressive erosive autoimmune disease that affects 1% of the world population. Anti-citrullinated protein autoantibodies (ACPA) are routinely used for the diagnosis of RA, however 20–30% of patients are ACPA negative. ACPA
Sunil Nagpal +2 more
exaly +3 more sources
Variable domain glycosylation of ACPA-IgG: A missing link in the maturation of the ACPA response?
Clinical Immunology, 2018 Anti-citrullinated Protein Antibodies (ACPA) are excellent markers for Rheumatoid arthritis (RA) and are postulated to have a pathogenic role in the disease process. A multistep model for the evolution of the ACPA response in RA was proposed in which an initial break of tolerance causes, as "first hit", "silent" production of ACPA without any clinical ...
Hans Ulrich Scherer +2 more
exaly +4 more sources
Frontiers in ImmunologyObjectiveTo investigate whether patients with ACPA-negative (ACPA–) and ACPA-positive (ACPA+) rheumatoid arthritis (RA) exhibit distinct immune and metabolic profiles in blood, using integrative proteomic and metabolomic analyses.
Cynthia S Crowson +2 more
exaly +3 more sources
The bidirectional effect of prelimbic 5-hydroxytryptamine type-4 (5-HT4) receptors on ACPA-mediated aversive memory impairment in adult male Sprague-Dawley rats [PDF]
Iranian Journal of Basic Medical Sciences, 2021 Objective(s): This study aimed at investigating the effect of serotonergic 5-HT4 receptor agonist/antagonist on memory consolidation deficit induced by ACPA (a potent, selective CB1 cannabinoid receptor agonist) in the pre-limbic (PL) cortex.
Nargol Ahmadi-Mahmoodabadi +3 more
doaj +1 more source
Exploring the landscape of aesthetic pharmacy practice
Exploratory Research in Clinical and Social Pharmacy, 2023 Background: As pharmacy practice evolves, an increasing number of pharmacists are diversifying into non-traditional roles such as aesthetic procedures.
Kamal Alhallak
doaj +1 more source
Recurrent ACPA-positive pericarditis, would it be a pre-clinical manifestation of RA?
Romanian Journal of Cardiology, 2023 Rheumatoid arthritis (RA) is a chronic inflammatory rheumatic disease with an autoimmune component that preferentially affects the small joints of the hands and feet. Extra-articular manifestations may be associated with it.
Laila Hamri, Samira Rabhi
doaj +1 more source
Sleep disturbance after cessation of cannabis administration in mice
Neuropsychopharmacology Reports, 2023 Cannabis withdrawal syndrome (CWS) in humans is characterized by various somatic symptoms, including sleep disturbances. In the present study, we investigated sleep alterations in mice after the cessation of arachidonylcyclopropylamide (ACPA), a ...
Takashi Asano +6 more
doaj +1 more source