Integrative multi-omic profiling in blood reveals distinct immune and metabolic signatures between ACPA-negative and ACPA-positive rheumatoid arthritis [PDF]
Frontiers in ImmunologyObjectiveTo investigate whether patients with ACPA-negative (ACPA–) and ACPA-positive (ACPA+) rheumatoid arthritis (RA) exhibit distinct immune and metabolic profiles in blood, using integrative proteomic and metabolomic analyses.
Kenneth Warrington +2 more
exaly +4 more sources
ACPA-negative rheumatoid arthritis: From immune mechanisms to clinical translation
EBioMedicine, 2022 Summary: The presence of anti-citrullinated protein autoantibodies (ACPA) is a hallmark feature of rheumatoid arthritis (RA), which causes chronic joint destruction and systemic inflammation.
Lidan Zhao, Xuan Zhang, Yudong Liu
exaly +3 more sources
ACPA Status Correlates with Differential Immune Profile in Patients with Rheumatoid Arthritis
Cells, 2021 Rheumatoid arthritis (RA) is a progressive erosive autoimmune disease that affects 1% of the world population. Anti-citrullinated protein autoantibodies (ACPA) are routinely used for the diagnosis of RA, however 20–30% of patients are ACPA negative. ACPA
Ronan Hugh Mullan +2 more
exaly +3 more sources
Rheumatoid factor and anticitrullinated protein antibody status jointly influence the association between disease activity and cardiovascular risk in rheumatoid arthritis [PDF]
RMD OpenObjectives Rheumatoid factor (RF) and anticitrullinated protein antibodies (ACPA) are linked to disease activity, severity and cardiovascular risk in rheumatoid arthritis (RA).
Carol A Hitchon +14 more
doaj +2 more sources
The bidirectional effect of prelimbic 5-hydroxytryptamine type-4 (5-HT4) receptors on ACPA-mediated aversive memory impairment in adult male Sprague-Dawley rats [PDF]
Iranian Journal of Basic Medical Sciences, 2021 Objective(s): This study aimed at investigating the effect of serotonergic 5-HT4 receptor agonist/antagonist on memory consolidation deficit induced by ACPA (a potent, selective CB1 cannabinoid receptor agonist) in the pre-limbic (PL) cortex.
Nargol Ahmadi-Mahmoodabadi +3 more
doaj +1 more source
Exploring the landscape of aesthetic pharmacy practice
Exploratory Research in Clinical and Social Pharmacy, 2023 Background: As pharmacy practice evolves, an increasing number of pharmacists are diversifying into non-traditional roles such as aesthetic procedures.
Kamal Alhallak
doaj +1 more source
Recurrent ACPA-positive pericarditis, would it be a pre-clinical manifestation of RA?
Romanian Journal of Cardiology, 2023 Rheumatoid arthritis (RA) is a chronic inflammatory rheumatic disease with an autoimmune component that preferentially affects the small joints of the hands and feet. Extra-articular manifestations may be associated with it.
Laila Hamri, Samira Rabhi
doaj +1 more source
Sleep disturbance after cessation of cannabis administration in mice
Neuropsychopharmacology Reports, 2023 Cannabis withdrawal syndrome (CWS) in humans is characterized by various somatic symptoms, including sleep disturbances. In the present study, we investigated sleep alterations in mice after the cessation of arachidonylcyclopropylamide (ACPA), a ...
Takashi Asano +6 more
doaj +1 more source
Scientific Reports, 2023 Patients with rheumatoid arthritis (RA) can test either positive or negative for circulating anti-citrullinated protein antibodies (ACPA) and are thereby categorized as ACPA-positive (ACPA+) or ACPA-negative (ACPA−), respectively. In this study, we aimed
Kevin Y. Cunningham +17 more
doaj +1 more source
Arthritis Research & Therapy, 2020 Background The positivity of anti-citrullinated protein/peptide antibodies (ACPAs) is a clinically useful diagnostic and prognostic marker in rheumatoid arthritis (RA). However, the significance of ACPA titer and its fluctuation remain unclear.
Koichi Murata +7 more
doaj +1 more source