Results 31 to 40 of about 8,833 (185)

Influence of Oral Microbiota on the Presence of IgA Anti-Citrullinated Protein Antibodies in Gingival Crevicular Fluid

Frontiers in Oral Health, 2022
IntroductionThe relation between rheumatoid arthritis (RA) and periodontitis (PD) has been investigated ever since the discovery of the citrullinating enzyme peptidyl arginine deaminase presents in the oral bacterium Porphyromonas gingivalis.
Menke J. de Smit, Menke J. de Smit, Poerwati Soetji Rahajoe, Elisabeth Raveling-Eelsing, Paola Lisotto, Hermie J. M. Harmsen, Nyoman Kertia, Arjan Vissink, Johanna Westra   +8 more
doaj   +1 more source

Are antibodies to fine specificities of citrullinated peptides/proteins useful for stratification of rheumatoid arthritis patients?

Clinical & Translational Immunology, 2021
Background In rheumatoid arthritis (RA), antibodies to citrullinated protein (ACPA) are believed to be heterogeneous and patient stratification by antibody profiling raised clinical interest for patient management.
Leonor Nogueira, Emilie Parra, Margaux Larrieu, Evelyne Verrouil, Martin Cornillet   +4 more
doaj   +1 more source

Multicentre study to improve clinical interpretation of rheumatoid factor and anti-citrullinated protein/peptide antibodies test results

RMD Open, 2022
Background Rheumatoid factor (RF) and anti-citrullinated protein/peptide antibodies (ACPA) are important biomarkers for diagnosis of rheumatoid arthritis (RA). However, there is poor harmonisation of RF and ACPA assays.
Lieve Van Hoovels, Xavier Bossuyt, Daniel Aletaha, Christopher Sjöwall, Stefanie Van den Bremt, Diego Kyburz, Alf Kastbom, Peggy Jacques, Laura Bogaert, Carolien Bonroy, Bert Vander Cruyssen, Ingmar Heijnen, Patrick Verschueren, Charlotte Dahle, Rille Pullerits, Saša Čučnik, Guenter Steiner, Daniela Sieghart, Eszter Nagy, Luca Bernasconi, Farid Benkhadra, Ann Van Liedekerke, Geert Vanheule, Johan Robbrecht, Lucy Studholme, Claudine Wirth, Rüdiger Müller, Rok Ješe, Boja Jovancevic, Emese Kiss   +29 more
doaj   +1 more source

Autoantibodies to citrullinated proteins: ACPA

Autoimmunity, 2005
Anti-perinuclear factor and anti-keratin antibodies have long been known to be specifically associated with rheumatoid arthritis (RA). They were first demonstrated to target various forms of (pro)filaggrin, a protein of stratified epithelia. Then, they were found to belong to a single family of autoantibodies targeting proteins that bear peptidic ...
Christian, Vincent, Leonor, Nogueira, Cyril, Clavel, Mireille, Sebbag, Guy, Serre   +4 more
openaire   +2 more sources

The Influence of Anti-Citrullinated Polypeptide Antibodies on Bone Mineral Density Decrease and Incident Major Osteoporotic Fractures in Patients with Rheumatoid Arthritis: A Retrospective Case-Control Study

Osteology, 2023
Background: Effects of anti-citrullinated polypeptide antibodies (ACPA) on the bone mineral density (BMD) reduction and incidence of major osteoporotic fractures (MOF) in patients with rheumatoid arthritis (RA) were evaluated using a retrospective ...
Ichiro Yoshii, Tatsumi Chijiwa, Naoya Sawada   +2 more
doaj   +1 more source

Misdiagnosis of Rheumatoid Arthritis in a Long-Term Cohort of Early Arthritis Based on the ACR-1987 Classification Criteria

Open Access Rheumatology: Research and Reviews, 2022
Monica Leu Agelii,1 Ingiäld Hafström,2 Björn Svensson,3 Sofia Ajeganova,4,5 Kristina Forslind,3,5 Maria Andersson,3,5 Inger Gjertsson1 1Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, Gothenburg ...
Leu Agelii M, Hafström I, Svensson B, Ajeganova S, Forslind K, Andersson M, Gjertsson I   +6 more
doaj  

The fine specificity of IgM anti-citrullinated protein antibodies (ACPA) is different from that of IgG ACPA [PDF]

Arthritis Research & Therapy, 2011
Abstract Introduction The antigen recognition pattern of immunoglobulin M (IgM) could, when directed against protein antigens, provide an indication of the antigenic moieties triggering new B cells. The half-life of IgM is short and memory B cells against T-cell-dependent protein antigens typically ...
Suwannalai, Parawee; Willemze, Annemiek; van Toorn, Linda; Stoeken-Rijsbergen, Gerrie; Levarht, Nivine; Drijfhout, Jan Wouter; Huizinga, Tom W. J.; Toes, Rene E. M.; Trouw, Leendert A.   +9 more
openaire   +3 more sources

Burning controversies in NETs and autoimmunity: The mysteries of cell death and autoimmune disease

Autoimmunity, 2018
The causes and mechanisms of autoimmune disease pose continuing challenges to the scientific community. Recent clues implicate a peculiar feature of neutrophils, their ability to release nuclear chromatin in the form of neutrophil extracellular traps ...
Nishant Dwivedi, Marko Radic
doaj   +1 more source

Analysis of ACPA positivity and ACPA fine specificities in a large Swedish twin cohort (TwinGene) [PDF]

Annals of the Rheumatic Diseases, 2012
Backgroundand objectives Genetic factors play a significant role in the variance of susceptibility for anticitrullinated protein antibodies (ACPA)-positive RA (Woude et al 2009). The authors wanted to study ACPA positivity as an entity and aimed to investigate the influence of genetic and environmental factors for ACPA positivity using a twin study ...
Aase Haj Hensvold, Patrik K E Magnusson, Monika Hansson, Lena Israelsson, Cecilia Carlens, Rikard Holmdahl, Per-Johan Jakobsson, Johan Askling, Tomas Ekström, Vivianne Malmström, Lars Klareskog, Anca Irinel Catrina   +11 more
openaire   +1 more source

The prevalence of ACPA is lower in rheumatoid arthritis patients with an older age of onset but the composition of the ACPA response appears identical

Arthritis Research & Therapy, 2017
Background Rheumatoid arthritis (RA) consists of two syndromes, one autoantibody-positive and one autoantibody-negative. Existing data on the relation between age of onset and prevalence of autoantibodies were conflicting.
Debbie M. Boeters, Lukas Mangnus, Sofia Ajeganova, Elisabet Lindqvist, Björn Svensson, René E. M. Toes, Leendert A. Trouw, Tom W. J. Huizinga, Francis Berenbaum, Jacques Morel, Solbritt Rantapää-Dahlqvist, Annette H. M. van der Helm-van Mil   +11 more
doaj   +1 more source