Results 51 to 60 of about 5,038 (172)

HLA-DRB1 genotype frequency in ACPA(+) and ACPA(−) RA patients and controls.

, 2014
ACPA: anti-citrullinated peptide antibody, ACPA(+): ACPA-positive, ACPA(−): ACPA-negative, RA: rheumatoid arthritis, SE: Shared epitope, OR: odds ratio, CI: confidence interval, Allele carrier frequencies are shown in parenthesis (%).
Hiroshi Furukawa (290179), Hajime Sano (12547), Masao Katayama (518771), Shomi Oka (290181), Naoshi Fukui (86346), Aya Kawasaki (518768), Akiko Komiya (290188), Kota Shimada (152649), Shinichiro Tsunoda (574965), Shigeto Tohma (290204), Shoji Sugii (290183), Naoyuki Tsuchiya (290203), Kiyoshi Migita (290200), Atsushi Hashimoto (290186), Satoshi Ito (12555), Koichiro Saisho (574964), Tadashi Nakamura (323696), Shouhei Nagaoka (290202), Akiko Suda (290201)   +18 more
core   +1 more source

HLA-DRB1 allele carrier frequency in ACPA(+) and ACPA(−) RA patients and controls.

, 2014
ACPA: anti-citrullinated peptide antibody, ACPA(+): ACPA-positive, ACPA(−): ACPA-negative, RA: rheumatoid arthritis, OR: odds ratio, CI: confidence interval, Pc: corrected P value, NS: not significant. Allele carrier frequencies are shown in parenthesis (
Hiroshi Furukawa (290179), Hajime Sano (12547), Masao Katayama (518771), Shomi Oka (290181), Naoshi Fukui (86346), Aya Kawasaki (518768), Akiko Komiya (290188), Kota Shimada (152649), Shinichiro Tsunoda (574965), Shigeto Tohma (290204), Shoji Sugii (290183), Naoyuki Tsuchiya (290203), Kiyoshi Migita (290200), Atsushi Hashimoto (290186), Satoshi Ito (12555), Koichiro Saisho (574964), Tadashi Nakamura (323696), Shouhei Nagaoka (290202), Akiko Suda (290201)   +18 more
core   +1 more source

IgG antibodies to cyclic citrullinated peptides exhibit profiles specific in terms of IgG subclasses, Fc-glycans and a fab-Peptide sequence.

PLoS ONE, 2014
The Fc-glycan profile of IgG1 anti-citrullinated peptide antibodies (ACPA) in rheumatoid arthritis (RA) patients has recently been reported to be different from non-ACPA IgG1, a phenomenon which likely plays a role in RA pathogenesis.
Susanna L Lundström, Cátia Fernandes-Cerqueira, A Jimmy Ytterberg, Elena Ossipova, Aase H Hensvold, Per-Johan Jakobsson, Vivianne Malmström, Anca I Catrina, Lars Klareskog, Karin Lundberg, Roman A Zubarev   +10 more
doaj   +1 more source

Cytokine Pathways Driving Diverse Tissue Pathologies in Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Rheumatoid arthritis (RA) is a complex systemic disorder characterized primarily by articular inflammation and destruction with associated functional loss and reduced quality of life. RA is also associated with extra‐articular disease, such as that of the lung, with potentially devastating clinical consequences. The critical importance of comorbidities,
Aurelie Najm, Lyn D. Ferguson, Iain B. McInnes   +2 more
wiley   +1 more source

Lung Ultrasound for the Detection of Radiologic Progression of Interstitial Lung Abnormalities in Patients With Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Objective Interstitial lung disease (ILD) is an important extra‐articular manifestation of rheumatoid arthritis (RA) associated with high mortality and morbidity. Lung ultrasonography (LUS) has recently emerged as a possible screening tool. We assessed the role of LUS in monitoring radiologic progression and the development of new interstitial lung ...
Marie Vermant, Valerie Van Ballaer, Joseph Jacob, Tine Follet, Ryoko Egashira, Kenny Anseele, Heleen Cypers, Laurens J. De Sadeleer, Nico De Crem, Tinne Goos, Barbara Neerinckx, Veerle Taelman, Nathalie Veyt, Alexandros Kalkanis, Patrick Verschueren, Wim A. Wuyts   +15 more
wiley   +1 more source

Independent association of HLA-DPB1*02:01 with rheumatoid arthritis in Japanese populations. [PDF]

PLoS ONE, 2018
OBJECTIVE:Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized with joint destructions; environmental and genetic factors were thought to be involved in the etiology of RA. The production of anti-citrullinated peptide antibodies (ACPA)
Hiroshi Furukawa, Shomi Oka, Kota Shimada, Atsushi Hashimoto, Akiko Komiya, Shinichiro Tsunoda, Akiko Suda, Satoshi Ito, Koichiro Saisho, Masao Katayama, Satoshi Shinohara, Takeo Sato, Katsuya Nagatani, Seiji Minota, Toshihiro Matsui, Naoshi Fukui, Shoji Sugii, Hajime Sano, Kiyoshi Migita, Shouhei Nagaoka, Shigeto Tohma   +20 more
doaj   +1 more source

Summary of the HLA-DRB1 alleles associated with ACPA-negative RA and ACPA-positive RA.

, 2012
The relationships between the RF-positive and RF-negative subsets of ACPA-negative and ACPA-positive RA in terms of their associations with HLA-DRB1 alleles are illustrated.
Kiyoshi Takasugi (152653), Kazuo Tajima (152656), Akira Murasawa (152651), Kazuhiko Yamamoto (8762), Keitaro Matsuo (73893), Chikashi Terao (137128), Katsunori Ikari (137132), Shigeki Momohara (137138), Kota Shimada (152649), Hisashi Yamanaka (137140), Masaki Katayama (152645), Kimiko Yurugi (152647), Akari Suzuki (137130), Yuta Kochi (24324), Etsuko Maruya (152643), Fumihiko Matsuda (137136), Tsuneyo Mimori (114039), Koichiro Ohmura (137137), Hiroo Saji (152662), Shigeru Honjo (152652), Ryo Yamada (8761)   +20 more
core   +1 more source

Autoantibodies to Joint‐Related Peptides Are Associated With Onset of Rheumatoid Arthritis in Presymptomatic Seronegative Individuals

Arthritis &Rheumatology, EarlyView.
Objective To identify autoantibodies in presymptomatic individuals that associate with the onset of rheumatoid arthritis (RA) and to distinguish early RA from osteoarthritis (OA), particularly in individuals lacking classic RA serologic markers. Methods We analyzed serum and plasma from three cohorts: presymptomatic individuals who later developed RA ...
Outi Sareila, Linda Johansson, Anders Lundquist, Monica Leu Agelii, Lei Cheng, Yibo He, Erik Lönnblom, Maria Andersson, Jan Kihlberg, Anders Esberg, Inger Gjertsson, Rikard Holmdahl, Solbritt Rantapää‐Dahlqvist   +12 more
wiley   +1 more source

The pathogenic role of ACPA in rheumatoid arthritis

Japanese Journal of Clinical Immunology, 2017
  In rheumatoid arthritis (RA), ACPA (anti-citrullinated protein/peptide antibody) is elevated with high specificity, and clinically, anti-CCP (cyclic citrullinated peptide) antibody is widely used for diagnosis of RA. It is thought ACPAs are produced with genetic background such as HLA-DR, environmental factors such as periodontal disease and smoking,
Naoto, Umeda, Isao, Matsumoto, Takayuki, Sumida   +2 more
openaire   +3 more sources

Autoreactivity Versus Autoimmunity: Characteristics of Autoantigen‐Specific CD4 T Cells in Rheumatoid Arthritis and Health

Arthritis &Rheumatology, EarlyView.
Objective CD4 T cells specific for citrullinated (cit) peptides are key players in rheumatoid arthritis (RA) immunopathogenesis. Characterizing these cells and identifying features of healthy and RA‐associated autoreactivity will provide valuable insight into disease mechanisms and form the basis of immune state biomarkers to facilitate the next ...
James A. Stanway, Daniel Peters, Helen Waller, Jeremy Lakey, Henrique De Paula Lemos, Kristian Williams, Abbie Degnan, Julie Diboll, Abdul Mannan Baru, David Tough, Arthur G. Pratt, Catharien M.U. Hilkens, Amy E. Anderson, John D. Isaacs   +13 more
wiley   +1 more source