Results 71 to 80 of about 5,038 (172)

The association between systemic inflammation as measured by calprotectin and autoantibody load in rheumatoid arthritis

Arthritis &Rheumatology, Accepted Article.
Background Plasma calprotectin is a marker of neutrophil activity. Its relation to the clinical phenotype and autoantibodies in rheumatoid arthritis (RA) is only partly understood. We therefore aimed to investigate the association between calprotectin and clinical parameters, CRP, ESR, anti‐CCP2 and other anti‐modified protein autoantibodies (AMPAs) in
Caroline Grönwall, Linda Mathsson Alm, Helga Westerlind, Isabel Gehring, Nasim Ghasemzadeh, Niels Steen Krogh, Siri Lillegraven, Espen Haavardsholm, Martina Johannesson, Tore K. Kvien, Johan Rönnelid, Tue Wenzel Kragstrup, Bente Glintborg, Merete Lund Hetland, Hilde Berner Hammer, The Danish Rheumatologic Biobank Study Group, Swedish Rheumatology Quality Register Biobank Study Group(SRQb), Johan Askling, Oliver Hendricks, Estrid Høgdall, Dorte Vendelbo Jensen, Heidi Lausten Munk, Jens Kristian Pedersen, Torkell Ellingsen, Anne Gitte Loft, Ellen‐Margrethe Hauge, Salome Kristensen, Lene Dreyer, Asta Linauskas, Søren Jacobsen, Carl Turesson, Solbritt Rantapää Dahlqvist, Lena Björkman, Alf Kastbom, Eva Baecklund   +34 more
wiley   +1 more source

ACPA response in evolution of rheumatoid arthritis [PDF]

, 2012
The ACPA response is different from conventional antibody responses. The ACPA response is generally of a much lower avidity than recall responses. Avidity maturation is limited and occurs before disease onset.
Suwannalai, P.
core  

Tofacitinib Regulates β‐Catenin Nuclear Translocation to Inhibit FLS Migration and Alleviate Clinical Symptoms of RA

iNew Medicine, EarlyView.
ABSTRACT Objective Tofacitinib is a Janus kinase (JAK) inhibitor approved for the treatment of moderate‐to‐severe rheumatoid arthritis (RA). However, its synovium‐related molecular mechanisms, particularly its regulatory effect on fibroblast‐like synoviocyte (FLS) migration, remain incompletely understood.
Shuqi Fang, Tianjing Zhang, Ling Hu, Ruijin Liu, Leyi Jia, Menglin Bai, Jiale Dong, Yuchen Zhao, Han Wang, Lei Zhang, Tao Li, Youcai Deng, Xianzheng Zhang, Lingling Zhang   +13 more
wiley   +1 more source

Disulfidptosis‐ and Ferroptosis‐Related Gene Signatures in Rheumatoid Arthritis: Association Analysis and Diagnostic Model Construction

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent synovial inflammation and progressive joint damage. Although ferroptosis has been implicated in RA progression, the role of disulfidptosis and its interaction with ferroptosis remains unclear.
Ting‐Ting Wang, Dong‐Mei Wang, Xue Li, Yuan‐Li Wei, Ping‐Dan Liu, Shi‐Lin Li, Si‐Ying Xiong, Cai‐Zhen Liu, Fan‐Xin Zeng, Jian‐Hong Wu, Lin Tang   +10 more
wiley   +1 more source

The frequency distribution of HLA-DRB1*04 subtypes among DRB1*04 positive and ACPA-positive or ACPA-negative RA patients by ethnic group.

, 2013
€,¥,§The frequency of DRB1 genotypes in ACPA subgroups was calculated as the number of ACPA-positive or ACPA-negative rheumatoid arthritis(RA) cases for a specific DRB1 allele (DRB1*04 +)divided by the total number of cases within that ACPA subgroup ...
Jasbir Singh Dhaliwal (350002), Lars Klareskog (4149), Leonid Padyukov (39206), Emeli Lundström (350003), Shahnaz Murad (310087), Too Chun-Lai (350001), Abqariyah Yahya (350004), Nor Asiah Muhamad (350005), Per Tobias Larsson (350006), Lars Alfredsson (39207)   +9 more
core   +1 more source

Synthesis of Poly(Itaconate)s With High Monomer Conversion Applying Emulsion Polymerization

Journal of Polymer Science, Volume 63, Issue 6, Page 1284-1296, 15 March 2025.
Itaconic acid and its derivatives are a promising and bio‐based substitute for oil‐based polymers such as acrylates. In this study, the optimization of polymerization of itaconic acid esters is described by applying emulsion polymerization leading to high reaction conversions and low residual monomer contents. ABSTRACT Itaconic acid and its derivatives
S. Charlotte Fischer von Mollard, Nico Ueberschaar, Martin Schreiber, Frank Kamphuis, Stefan Zechel, Martin D. Hager   +5 more
wiley   +1 more source

Clinical predictors of response to methotrexate in patients with rheumatoid arthritis: A systematic review

Rheumatology &Autoimmunity, EarlyView.
This review integrates clinical, immunological, genetic, and multi‐omic evidence, highlighting dynamic inflammatory and adenosine‐pathway biomarkers and reinforcing treat‐to‐target principles as the most actionable framework for personalized methotrexate therapy.
Joana Ramos Rodrigues, Helena Margarida de Miranda Lemos Romão Donato, Soraia Raquel Loureiro Azevedo, Luís Miguel da Silva Pires, Luís Pedro Bolotinha de Sousa Inês, Manuel Augusto Nunes Vicente Passos Morgado, Ana Filipa de Sousa Pestana Mourão   +6 more
wiley   +1 more source

ACPAs Are Much More Than Diagnostic Autoantibodies [PDF]

Rambam Maimonides Medical Journal, 2016
Anti-citrullinated protein autoantibodies (ACPAs) are the major autoantibodies in rheumatoid arthritis (RA). Anti-citrullinated protein autoantibodies are directed against different citrullinated antigens, including filaggrin, fibrinogen, vimentin, and collagen.
Abdulla Watad, Howard Amital
openaire   +3 more sources

Direct comparison of HLA-DRB1 allele frequency between ACPA-negative RF-positive RA and ACPA-negative RF-negative RA.

, 2012
Direct comparison of HLA-DRB1 allele frequency between ACPA-negative RF-positive RA and ACPA-negative RF-negative RA.
Kiyoshi Takasugi (152653), Kazuo Tajima (152656), Akira Murasawa (152651), Kazuhiko Yamamoto (8762), Keitaro Matsuo (73893), Chikashi Terao (137128), Katsunori Ikari (137132), Shigeki Momohara (137138), Kota Shimada (152649), Hisashi Yamanaka (137140), Masaki Katayama (152645), Kimiko Yurugi (152647), Akari Suzuki (137130), Yuta Kochi (24324), Etsuko Maruya (152643), Fumihiko Matsuda (137136), Tsuneyo Mimori (114039), Koichiro Ohmura (137137), Hiroo Saji (152662), Shigeru Honjo (152652), Ryo Yamada (8761)   +20 more
core   +1 more source

ACPA-positive and ACPA-negative rheumatoid arthritis differ in their requirements for combination DMARDs and corticosteroids: secondary analysis of a randomized controlled trial [PDF]

, 2014
IntroductionUK guidelines recommend that all early active rheumatoid arthritis (RA) patients are offered combination disease-modifying antirheumatic drugs (DMARDs) and short-term corticosteroids.
Margaret HY Ma, David L Scott, Cope, Andrew P, Scott, David L, Seth D Seegobin, Scott, Ian C, Ian C Scott, Andrew P Cope, Seegobin, Seth D, Ma, Margaret Hy, Chanaka Dahanayake, Dahanayake, Chanaka, Cathryn M Lewis, Lewis, Cathryn M; id_orcid   +13 more
core   +1 more source