Results 81 to 90 of about 8,833 (185)

Patients with obesity have more inflamed joints and higher CRP levels during the disease course in ACPA-positive RA but not in ACPA-negative RA

Arthritis Research & Therapy
Background Obese RA patients have higher disease activity scores (DAS). Previous research showed that obese RA patients have higher tender joint count (TJC) and VAS general health.
N. K. den Hollander, A. M. P Boeren, A. H. M. van der Helm-van Mil, H. W. van Steenbergen   +3 more
doaj   +1 more source

Dual rheumatoid factor and anti-cyclic citrullinated peptide antibody positivity affects the manifestations of rheumatoid arthritis

Singapore Medical Journal
Introduction: Rheumatoid factor (RF) and anti-cyclic citrullinated peptide antibody (ACPA) are used in the diagnosis and prognostication of rheumatoid arthritis (RA).
Li Huan Angela Marie Chan, Khai Pang Leong, Justina Wei Lynn Tan, Xiao Gao, Wei Qiang See, Ee Tzun Koh, Tan Tock Seng Hospital Rheumatoid Arthritis Study Group   +6 more
doaj   +1 more source

Special issue on 4th ACPA [PDF]

Precision Agriculture, 2013
I would like to express my appreciation to the 18 paper authors and more than 40 reviewers, as well as Dr. J. Stafford as the editor-in-chief and Dr. J. Schepers as the coeditor-in-chief, for their great efforts. After the peer review, three papers were accepted.
openaire   +1 more source

Anti‐Modified Protein Antibodies in Rheumatoid Arthritis: Pathogenic, Protective, or Passive Bystander?

Immunological Reviews, Volume 341, Issue 1, August 2026.
ABSTRACT The presence of anti‐modified protein antibodies (AMPA) is a hallmark of rheumatoid arthritis (RA). AMPA recognize post‐translationally modified proteins and are cross‐reactive. AMPA include anti‐citrullinated protein antibodies (ACPA), anti‐carbamylated protein antibodies (anti‐CarP), and anti‐acetylated protein antibodies (AAPA).
Amber‐Sarai F. L. Stalman, Diane van der Woude   +1 more
wiley   +1 more source

The TG2/LRP1 Pathway for T Cell Activation by Post‐Translationally Modified Antigens

Immunological Reviews, Volume 341, Issue 1, August 2026.
ABSTRACT Post‐translational modifications (PTMs) can generate neo‐epitopes, modified peptides that evade immune tolerance and trigger immune responses. This review focuses on the TG2/LRP1 pathway as a new paradigm for coupling the formation of post‐translationally modified peptides with their effective presentation as T‐cell antigens by dendritic cells.
Agnele Sylvia Sewa, Fu‐Chen Yang, Chaitan Khosla   +2 more
wiley   +1 more source

Synovial Fluid Cell Profiling Identifies Distinct Inflammatory Phenotypes in Late‐Onset Rheumatoid Arthritis and Polymyalgia Rheumatica

ACR Open Rheumatology
Objective Late‐onset rheumatoid arthritis (LORA) and polymyalgia rheumatica (PMR) can be difficult to distinguish, particularly in anti–citrullinated protein antibody (ACPA)‐negative patients.
Shigeru Tanaka, Takahiro Sugiyama, Shuhei Kameda, Tatsuro Takahashi, Masahiro Yasui, Yuki Hayashi, Tomoaki Ida, Yuhi Yoshida, Soichiro Kubota, Takashi Ito, Takahiro Kageyama, Daiki Nakagomi, Kei Ikeda, Shin‐Ichiro Kagami, Hiroshi Nakajima   +14 more
doaj   +1 more source

Serum test for secretory component-containing anti-citrullinated protein antibodies as a novel prognostic tool in rheumatoid arthritis at-risk subjects

Journal of Translational Autoimmunity
Individuals with autoantibodies against citrullinated proteins (ACPA) and musculoskeletal symptoms face increased risk of developing rheumatoid arthritis (RA).
Klara Martinsson, Simon Åhammar, Alexandra Cîrciumaru, Bence Réthi, Michael Ziegelasch, Aase Hensvold, Alf Kastbom   +6 more
doaj   +1 more source

Metabolic reprogramming and macrophage expansion define ACPA-negative rheumatoid arthritis: insights from single-cell RNA sequencing

Frontiers in Immunology
BackgroundAnti-citrullinated peptide antibodies (ACPA)-negative (ACPA−) rheumatoid arthritis (RA) presents significant diagnostic and therapeutic challenges due to the absence of specific biomarkers, underscoring the need to elucidate its distinctive ...
Yafeng Jiang, Zhaolan Hu, Roujie Huang, Kaying Ho, Pengfei Wang, Jin Kang, Jin Kang   +6 more
doaj   +1 more source

Rheumatoid factor and anti-cyclic citrullinated peptide antibody levels decline in rheumatoid arthritis patients treated with Janus kinase inhibitors or biological disease-modifying anti-rheumatic drugs

Journal of Rheumatic Diseases
Objective: We aimed to investigate the rate of decline in serum anti-cyclic citrullinated peptide antibody (ACPA) and rheumatoid factor (RF) levels in rheumatoid arthritis (RA) patients treated with Janus kinase inhibitors (JAKis) compared with ...
Bo Young Kim, Ji-Won Kim, Hwajeong Lee, Sung-Hoon Park, Seong-Kyu Kim, Jung-Yoon Choe   +5 more
doaj   +1 more source

Serum anticyclic citrullinated protein antibody titers are correlated with the response to biological agents in patients with rheumatoid arthritis

Open Access Rheumatology: Research and Reviews, 2014
Ryo Takahashi, Sakiko Isojima, Masayu Umemura, Yoko Miura, Nao Oguro, Syo Ishii, Shinya Seki, Takahiro Tokunaga, Hiroyuki Tsukamoto, Hidekazu Furuya, Ryo Yanai, Tsuyoshi KasamaDivision of Rheumatology, Department of Medicine, Showa University School of ...
Takahashi R, Isojima S, Umemura M, Miura Y, Oguro N, Ishii S, Seki S, Tokunaga T, Tsukamoto H, Furuya H, Yanai R, Kasama T   +11 more
doaj