Results 81 to 90 of about 5,038 (172)

An Immunochip-based interaction study of contrasting interaction effects with smoking in ACPA-positive versus ACPA-negative rheumatoid arthritis

, 2016
Objective: To investigate the gene–environment interaction between smoking and single nucleotide polymorphisms (SNPs), using Immunochip material, on the risk of developing either of two serologically defined subsets of RA.Methods: Interaction between ...
Rantapää-Dahlqvist, Solbritt,, Klareskog, Lars, Ärlestig, Lisbeth,, Chen, Zuomei, Padyukov, Leonid, Davila, Sonia, Alfredsson, Lars, Jiang, Xia, Kallberg, Henrik   +8 more
core   +1 more source

The Keystone‐Pathogen Hypothesis Updated: The Role of Porphyromonas gingivalis in Periodontitis

Journal of Periodontal Research, EarlyView.
Porphyromonas gingivalis orchestrates a coordinated manipulation of immune and inflammatory responses in periodontal tissues which leads to the generation of a dysbiotic, subgingival biofilm community, and progression of periodontitis. The type 9 secretion system, lipid A modification, and the formation of outer membrane vesicles are important ...
Mike A. Curtis, James A. Garnett, Richard P. Darveau   +2 more
wiley   +1 more source

Associations between synovial inflammation and circulating ACPA-IgG autoantibodies

, 2011
Copyright information:Taken from "Differential responsiveness to immunoablative therapy in refractory rheumatoid arthritis is associated with level and avidity of anti-cyclic citrullinated protein autoantibodies: a case study"http://arthritis-research ...
Robert J Verburg (8504), René EM Toes (11481), YK Onno Teng (39163), Tom WJ Huizinga (11482), Jacob M van Laar (8526), Maarten JD van Tol (39166), Els CM Jol-van der Zijde (39167), Kirsten N Verpoort (11479), Gwendolyn MP Diepenhorst (39164), Ingeborg M Bajema (39165)   +9 more
core   +1 more source

Autoimmunity and Periodontitis

Journal of Periodontal Research, EarlyView.
In a microbe‐driven inflammatory environment, peptidyl‐arginine deiminase (PAD) enzymes from neutrophils and Porphyromonas gingivalis citrullinate both microbial and self‐antigens. B cell presentation of citrullinated or self‐mimicking epitopes activates T cells that assist B cells in antibody isotype switching, affinity maturation, epitope spreading ...
Massimo Costalonga, Vivek Thumbigere‐Math, Mark C. Herzberg   +2 more
wiley   +1 more source

Standardisation of ACPA tests : evaluation of a new candidate reference preparation

, 2022
Introduction Commercial assays measuring antibodies to citrullinated protein/peptide (ACPA) show poor quantitative agreement. The diagnostic industry has never adopted the International Union of Immunological Societies-Centers for Disease Control and ...
Mueller, Ruediger,, Vanheule, G., Jovancevic, Boja,, Daniel Aletaha, Steiner, Guenter,, Verschueren, P., Wirth, Claudine, Jese, Rok, Dahle, Charlotte, Wirth, C., Jacques, Peggy, Carolien Bonroy, Sjowall, C., Sjöwall, Christopher,, Dahle, C., Günter Steiner, Dahle, Charlotte,, Van den Bremt, S., Sieghart, Daniela,, Aletaha, Daniel, Vanheule, Geert,, Cucnik, S., Pullerits, Rille, Nagy, Eszter,, Van Hoovels, Lieve, Kastbom, Alf, Pullerits, Rille,, Robbrecht, Johan, Rüdiger Müller, Jese, R., Vander Cruyssen, B., Kastbom, A., Bernasconi, Luca,, Muller, R., Bonroy, Carolien, Benkhadra, Farid, Kastbom, Alf,, Studholme, L., Aletaha, D., Müller, Rüdiger, Kiss, E., Studholme, Lucy, Sjöwall, Christopher, Kyburz, D., Claudine Wirth, Emese Kiss, Lieve Van Hoovels, Mueller, Ruediger, Benkhadra, F., Benkhadra, Farid,, Sieghart, Daniela, Vander Cruyssen, Bert,, Verschueren, Patrick, Sieghart, D., Geert Vanheule, Wirth, Claudine,, Bert Vander Cruyssen, Vanheule, Geert, Rille Pullerits, Lucy Studholme, Rok Ješe, Van Liedekerke, A., Bernasconi, L., Patrick Verschueren, Robbrecht, J., Steiner, Günter, Van Hoovels, Lieve,, Bonroy, Carolien,, Kyburz, Diego, Bossuyt, Xavier, Van den Bremt, Stefanie, Eszter Nagy, Bogaert, Laura, Alf Kastbom, Sasa Čučnik, Ann Van Liedekerke, Steiner, Guenter, Cucnik, Sasa, Cucnik, Sasa,, Bogaert, L., Kiss, Emese, Laura Bogaert, Verschueren, Patrick,, Bossuyt, X., Heijnen, Ingmar,, Bernasconi, Luca, Johan Robbrecht, Robbrecht, Johan,, Steiner, G., Jovancevic, Boja, Bogaert, Laura,, Van Hoovels, L., Luca Bernasconi, Peggy Jacques, Bonroy, C., Heijnen, I., Charlotte Dahle, Kiss, Emese,, Christopher Sjöwall, Xavier Bossuyt, Jacques, P., Van Liedekerke, Ann, Nagy, Eszter, Nagy, E., Heijnen, Ingmar, Aletaha, Daniel,, Stefanie Van Den Bremt, Bossuyt, Xavier,, Farid Benkhadra, Boja Jovancevic, Jese, Rok,, Studholme, Lucy,, Daniela Sieghart, Vander Cruyssen, Bert, Van Liedekerke, Ann,, Diego Kyburz, Kyburz, Diego,, Jacques, Peggy,, Ingmar Heijnen, Van den Bremt, Stefanie,   +119 more
core   +1 more source

Periodontal Medicine Rewired: Mechanisms Linking Periodontitis to Systemic Diseases

Journal of Periodontal Research, EarlyView.
This review reorganizes decades of research in periodontal medicine into a multi‐dimensional framework, illustrating how periodontitis influences systemic health through at least seven interconnected mechanisms. ABSTRACT Periodontitis is now recognized not merely as a localized oral condition but as a systemic disease linked to over 70 communicable and
Mario Romandini, George Hajishengallis, Mike Curtis, Giacomo Baima   +3 more
wiley   +1 more source

Anti-citrullinated protein antibodies (ACPA), at the heart of both rheumatoid arthritis and cardiovascular disease? The statistical analysis plan

, 2022
Statistical analysis plan for our study regarding anti-citrullinated protein antibodies in patients with coronary heart disease, without concomitant rheumatoid arthritis. Drafted and published before the start of data analysis.
Gluud, Christian, Leipe, Jan, Winkel, Per, Kleber, Markus, Toes, René, Krämer, Berhard, Huizinga, Tom, Derksen, Veerle, Jakobsen, Janus, März, Winfried, Van der Woude, Diane, Lindschou, Jane, Delgado, Graciela   +12 more
core   +1 more source

Periodontitis and Rheumatoid Arthritis—Mechanistic Evidence

Journal of Periodontal Research, EarlyView.
Periodontitis and rheumatoid arthritis are linked via the two‐hit model whereby early periodontal inflammation can lead to autoantibody production capable of interacting with inflamed synovial tissues. Subsequent systemic inflammation can exacerbate the periodontal inflammatory response and bacterial dysbiosis leading to further autoantibody production
Mark Bartold, Chia Wei Cheah, Rathna Devi Vaithilingam   +2 more
wiley   +1 more source

Using data to shape student engagement: NSSE and student affairs [PDF]

, 2007
Presented at the 2007 ACPA-NASPA Joint Meeting in Orlando ...
Kinzie, J., Jackson, J., Howard, C.
core   +1 more source

Periodontitis and Adverse Pregnancy Outcomes: Mechanistic Evidence

Journal of Periodontal Research, EarlyView.
This narrative review aims to describe mechanisms linking periodontal diseases in pregnancy with adverse pregnancy outcomes. ABSTRACT Periodontal diseases, including both gingivitis and periodontitis, occur commonly among pregnant individuals. Both gingivitis and periodontitis are associated with adverse pregnancy outcomes (APOs) such as early ...
Gregory C. Valentine, Yiorgos A. Bobetsis, Benjamin C. Shayo, Peter Milgrom, Phoebus N. Madianos   +4 more
wiley   +1 more source