Results 21 to 30 of about 5,038 (172)

Immunoprofiling of early, untreated rheumatoid arthritis using mass cytometry reveals an activated basophil subset inversely linked to ACPA status

Arthritis Research & Therapy, 2021
Background Autoantibody production is a hallmark of rheumatoid arthritis (RA). Anti-citrullinated protein antibodies (ACPA) are highly disease-specific, and their presence is associated with more severe disease and poor prognosis compared to ACPA ...
H. Koppejan, M. Hameetman, G. Beyrend, V. van Unen, J. C. Kwekkeboom, A. H. van der Helm-van Mil, R. E. M. Toes, F. A. van Gaalen   +7 more
doaj   +1 more source

Anti-Citrullinated Peptide Antibody Expression and Its Association with Clinical Features and Outcomes in Patients with Antineutrophil Cytoplasmic Antibody-Associated Vasculitis

Medicina, 2022
Background and objectives: Anti-citrullinated peptide antibody (ACPA), a characteristic antibody detected in rheumatoid arthritis, could be linked to antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) via the formation of neutrophil ...
Sung Soo Ahn, Jung Yoon Pyo, Jasong Jungsik Song, Yong-Beom Park, Sang-Won Lee   +4 more
doaj   +1 more source

The effect of the cannabinoid CB1 receptor agonist arachidonylcyclopropylamide (ACPA) on behavioural sensitisation to methamphetamine in mice

Veterinární Medicína, 2014
The psychostimulant methamphetamine (Met), similarly to other drugs of abuse, is known to produce an increased behavioural response after its repeated application (behavioural sensitisation).
L. Landa, K. Slais, A. Machalova, A. Sulcova   +3 more
doaj   +1 more source

How RA Associated HLA-DR Molecules Contribute to the Development of Antibodies to Citrullinated Proteins: The Hapten Carrier Model

Frontiers in Immunology, 2022
The risk to develop ACPA positive rheumatoid arthritis (RA), the most destructive type of autoimmune arthritis, is carried by HLA-DRB1 alleles containing a 5 amino acid motif: the shared epitope (SE).
Jean Roudier, Jean Roudier, Jean Roudier, Nathalie Balandraud, Nathalie Balandraud, Isabelle Auger, Isabelle Auger   +6 more
doaj   +1 more source

The extensive glycosylation of the ACPA variable domain observed for ACPA-IgG is absent from ACPA-IgM

Annals of the Rheumatic Diseases, 2018
Recently, we described the presence of highly sialylated N -linked glycans in the antigen-binding fragment (Fab) of almost all anti-citrullinated protein antibody (ACPA) IgG molecules.1 2 These glycans could not be found on several other autoantibody systems analysed.
Kempers, Ayla C.; Hafkenscheid, Lise; Dorjee, Annemarie L.; Moutousidou, Eleni; van de Bovenkamp, Fleur S.; Rispens, Theo; Trouw, Leendert A.; van Oosterhout, Maikel; Huizinga, Tom W. J.; Toes, Rene; Scherer, Hans Ulrich   +11 more
openaire   +6 more sources

The ACPA recognition profile and subgrouping of ACPA-positive RA patients

Annals of the Rheumatic Diseases, 2012
Anticitrullinated protein antibodies (ACPA) are the most predictive factor for the development of rheumatoid arthritis (RA). Epitope spreading towards more citrullinated epitopes occurs before the onset of RA. Here, the authors investigated whether specific epitope recognition allows the identification of specific RA subgroups and whether it is ...
Willemze, A., Bohringer, S., Knevel, R., Levarht, E.W.N., Stoeken-Rijsbergen, G., Houwing-Duistermaat, J.J., Helm-van Mil, A.H.M. van der, Huizinga, T.W.J., Toes, R.E.M., Trouw, L.A.   +9 more
openaire   +4 more sources

Memories of Past Presidents

Journal of College Orientation, Transition, and Retention, 2007
Six of NODA's past presidents shared their thoughts about NODA's history in a recent leadership survey compiled by Maria Sedotti of the University of Connecticut.
Denise L. Rode
doaj   +1 more source

Antibodies against citrullinated proteins of IgA isotype are associated with progression to rheumatoid arthritis in individuals at-risk

RMD Open, 2023
Objective Events triggering disease outbreak in individuals at-risk for rheumatoid arthritis (RA at-risk) remain unclear, and the role of the various anticitrullinated protein antibody (ACPA) isotypes in this process is still to be established.
Georg Schett, Holger Bang, Arnd Kleyer, Guenter Steiner, Daniela Sieghart, Fabian Hartmann, Maria V Sokolova, Ulrike Steffen   +7 more
doaj   +1 more source

The fine specificity of IgM anti-citrullinated protein antibodies (ACPA) is different from that of IgG ACPA [PDF]

Arthritis Research & Therapy, 2011
Abstract Introduction The antigen recognition pattern of immunoglobulin M (IgM) could, when directed against protein antigens, provide an indication of the antigenic moieties triggering new B cells. The half-life of IgM is short and memory B cells against T-cell-dependent protein antigens typically ...
Suwannalai, Parawee; Willemze, Annemiek; van Toorn, Linda; Stoeken-Rijsbergen, Gerrie; Levarht, Nivine; Drijfhout, Jan Wouter; Huizinga, Tom W. J.; Toes, Rene E. M.; Trouw, Leendert A.   +9 more
openaire   +3 more sources

OP0314 B cell phenotype and function in the synovium of acpa+ and acpa- rheumatoid arthritispatients [PDF]

Annals of the Rheumatic Diseases, 2018
Background Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease of unknown and complex etiology with severe detrimental effects for the patient’s quality of life. While rheumatoid factors (RF) and anti-citrulinated protein antibodies (ACPA) have been used extensively for the diagnosis of RA, no clear mechanism of action towards ...
A. Floudas, M. Biniecka, C. Low, D.J. Veale, U. Fearon   +4 more
openaire   +1 more source