Results 11 to 20 of about 24,710 (219)

Clinical features of ACPA-negative and ACPA-positive variants of rheumatoid arthritis

Научно-практическая ревматология, 2023
The aim of the study was to study the features of the clinical picture of the disease in patients with ACPA-negative and ACPA-positive variants of rheumatoid arthritis.Materials and methods.
D. A. Dibrov, A. S. Avdeeva, V. V. Rybakova, N. V. Demidova, E. L. Nasonov   +4 more
doaj   +3 more sources

CCR6+ Th cell populations distinguish ACPA positive from ACPA negative rheumatoid arthritis [PDF]

Arthritis Research & Therapy, 2015
Introduction: Patients with rheumatoid arthritis (RA) can be separated into two major subpopulations based on the absence or presence of serum anti-citrullinated protein antibodies (ACPAs).
Davelaar, N. (Nadine), Hamburg, J.P. (Jan Piet) van, Hazes, J.M.W. (Mieke), Jong, P.H.P. (Pascal) de, Lubberts, E.W. (Erik), Paulissen, S.M.J. (Sandra), Vroman, H. (Heleen)   +6 more
core   +4 more sources

Forefoot inflammation in recent-onset ACPA-positive and ACPA-negative RA: clinically similar, but different in underlying inflamed tissues

RMD Open
Objectives Although joint swelling is traditionally interpreted as synovitis, recent imaging studies showed that there is also inflammation of tenosynovium and intermetatarsal bursae in the forefoot.
Annette H.M. van der Helm - van Mil, Dennis A. Ton, Bastiaan T. van Dijk, Hanna W. van Steenbergen   +3 more
doaj   +5 more sources

ACPA-negative rheumatoid arthritis: From immune mechanisms to clinical translation

EBioMedicine, 2022
Summary: The presence of anti-citrullinated protein autoantibodies (ACPA) is a hallmark feature of rheumatoid arthritis (RA), which causes chronic joint destruction and systemic inflammation.
Ketian Li, Min Wang, Lidan Zhao, Yudong Liu, Xuan Zhang   +4 more
doaj   +1 more source

Recurrent ACPA-positive pericarditis, would it be a pre-clinical manifestation of RA?

Romanian Journal of Cardiology, 2023
Rheumatoid arthritis (RA) is a chronic inflammatory rheumatic disease with an autoimmune component that preferentially affects the small joints of the hands and feet. Extra-articular manifestations may be associated with it.
Laila Hamri, Samira Rabhi
doaj   +1 more source

Sleep disturbance after cessation of cannabis administration in mice

Neuropsychopharmacology Reports, 2023
Cannabis withdrawal syndrome (CWS) in humans is characterized by various somatic symptoms, including sleep disturbances. In the present study, we investigated sleep alterations in mice after the cessation of arachidonylcyclopropylamide (ACPA), a ...
Takashi Asano, Hiroki Takemoto, Tomoya Horita, Tomohiro Tokutake, Naotaka Izuo, Takatoshi Mochizuki, Atsumi Nitta   +6 more
doaj   +1 more source

Patients with ACPA-positive and ACPA-negative rheumatoid arthritis show different serological autoantibody repertoires and autoantibody associations with disease activity

Scientific Reports, 2023
Patients with rheumatoid arthritis (RA) can test either positive or negative for circulating anti-citrullinated protein antibodies (ACPA) and are thereby categorized as ACPA-positive (ACPA+) or ACPA-negative (ACPA−), respectively. In this study, we aimed
Kevin Y. Cunningham, Benjamin Hur, Vinod K. Gupta, Courtney A. Arment, Kerry A. Wright, Thomas G. Mason, Lynne S. Peterson, Delamo I. Bekele, Daniel E. Schaffer, Marissa L. Bailey, Kara E. Delger, Cynthia S. Crowson, Elena Myasoedova, Hu Zeng, Moses Rodriguez, Cornelia M. Weyand, John M. Davis, Jaeyun Sung   +17 more
doaj   +1 more source

Characterization of Autoantigens Targeted by Anti-Citrullinated Protein Antibodies In Vivo: Prominent Role for Epitopes Derived from Histone 4 Proteins. [PDF]

PLoS ONE, 2016
Anti-citrullinated protein antibodies (ACPA) have become an integral part of the clinical definition of rheumatoid arthritis, and are hypothesized to be important in the immunopathogenesis of this autoimmune disease.
Xiaobo Meng, Peyman Ezzati, Irene Smolik, Charles N Bernstein, Carol Ann Hitchon, Hani S El-Gabalawy   +5 more
doaj   +1 more source

Fluctuation in anti-cyclic citrullinated protein antibody level predicts relapse from remission in rheumatoid arthritis: KURAMA cohort

Arthritis Research & Therapy, 2020
Background The positivity of anti-citrullinated protein/peptide antibodies (ACPAs) is a clinically useful diagnostic and prognostic marker in rheumatoid arthritis (RA). However, the significance of ACPA titer and its fluctuation remain unclear.
Koichi Murata, Hiromu Ito, Motomu Hashimoto, Kosaku Murakami, Ryu Watanabe, Masao Tanaka, Wataru Yamamoto, Shuichi Matsuda   +7 more
doaj   +1 more source

Immunoprofiling of early, untreated rheumatoid arthritis using mass cytometry reveals an activated basophil subset inversely linked to ACPA status

Arthritis Research & Therapy, 2021
Background Autoantibody production is a hallmark of rheumatoid arthritis (RA). Anti-citrullinated protein antibodies (ACPA) are highly disease-specific, and their presence is associated with more severe disease and poor prognosis compared to ACPA ...
H. Koppejan, M. Hameetman, G. Beyrend, V. van Unen, J. C. Kwekkeboom, A. H. van der Helm-van Mil, R. E. M. Toes, F. A. van Gaalen   +7 more
doaj   +1 more source