Results 21 to 30 of about 24,710 (219)

The effect of the cannabinoid CB1 receptor agonist arachidonylcyclopropylamide (ACPA) on behavioural sensitisation to methamphetamine in mice

Veterinární Medicína, 2014
The psychostimulant methamphetamine (Met), similarly to other drugs of abuse, is known to produce an increased behavioural response after its repeated application (behavioural sensitisation).
L. Landa, K. Slais, A. Machalova, A. Sulcova   +3 more
doaj   +1 more source

Anti-Citrullinated Peptide Antibody Expression and Its Association with Clinical Features and Outcomes in Patients with Antineutrophil Cytoplasmic Antibody-Associated Vasculitis

Medicina, 2022
Background and objectives: Anti-citrullinated peptide antibody (ACPA), a characteristic antibody detected in rheumatoid arthritis, could be linked to antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) via the formation of neutrophil ...
Sung Soo Ahn, Jung Yoon Pyo, Jasong Jungsik Song, Yong-Beom Park, Sang-Won Lee   +4 more
doaj   +1 more source

How RA Associated HLA-DR Molecules Contribute to the Development of Antibodies to Citrullinated Proteins: The Hapten Carrier Model

Frontiers in Immunology, 2022
The risk to develop ACPA positive rheumatoid arthritis (RA), the most destructive type of autoimmune arthritis, is carried by HLA-DRB1 alleles containing a 5 amino acid motif: the shared epitope (SE).
Jean Roudier, Jean Roudier, Jean Roudier, Nathalie Balandraud, Nathalie Balandraud, Isabelle Auger, Isabelle Auger   +6 more
doaj   +1 more source

Anticarbamylated protein antibodies are associated with long-term disability and increased disease activity in patients with early inflammatory arthritis:Results from the Norfolk Arthritis Register [PDF]

, 2015
Objectives: Anticarbamylated protein (anti-CarP) antibodies are a novel family of autoantibodies recently identified in patients with inflammatory arthritis. The aim of this study was to investigate their association with long-term outcomes of disability
Aletaha, Alexander J MacGregor, Anne Barton, Arend, Brink, Burgers, Burska, De, Deborah PM Symmons, Gan, Hecht, Humphreys, Humphreys, Humphreys, Jennifer H Humphreys, Jung, Kosinski, Leendert A Trouw, Marije K Verheul, Mark Lunt, Montes, Nielen, Pope, Quinn, Rene EM Toes, Shi, Shi, Shi, Shidara, Sokolove, Suzanne MM Verstappen, Symmons, van der Helm-van Mil, van der Linden, Wiles, Wolfe, Yee   +36 more
core   +1 more source

Antibodies against citrullinated proteins of IgA isotype are associated with progression to rheumatoid arthritis in individuals at-risk

RMD Open, 2023
Objective Events triggering disease outbreak in individuals at-risk for rheumatoid arthritis (RA at-risk) remain unclear, and the role of the various anticitrullinated protein antibody (ACPA) isotypes in this process is still to be established.
Georg Schett, Holger Bang, Arnd Kleyer, Guenter Steiner, Daniela Sieghart, Fabian Hartmann, Maria V Sokolova, Ulrike Steffen   +7 more
doaj   +1 more source

The ACPA IgM fine specificity differs from the ACPA IgG antigen-recognition profile [PDF]

Annals of the Rheumatic Diseases, 2012
Background The antigen-recognition pattern of immunoglobulin M (IgM) could, in case directed against protein-antigens, provide an indication of the antigenic moieties triggering new B cells. The half-life of IgM is short and memory B cells against T cell dependent protein antigens, typically produce IgG and not IgM antibodies.
Willemze, A., Suwannalai, P., Toorn, L. van, Stoeken-Rijsbergen, G., Levarht, E.W.N., Drijfhout, J.W., Huizinga, T.W.J., Toes, R.E.M., Trouw, L.A.   +8 more
openaire   +2 more sources

Prevalence, sensitivity and specificity of antibodies against carbamylated proteins in a monocentric cohort of patients with rheumatoid arthritis and other autoimmune rheumatic diseases [PDF]

, 2016
Antibodies against carbamylated proteins (anti-CarP) have been recently identified in the sera of patients with rheumatoid arthritis (RA). The objective of the study was to evaluate the prevalence, sensitivity and specificity of anti-CarP compared to ...
Alessandri, Cristiano, Barbati, Cristiana, Ceccarelli, Fulvia, Colasanti, Tania, Conti, Fabrizio, DI FRANCO, Manuela, Mancini, Riccardo, Morello, Francesca, Pecani, Arbi, Pendolino, Monica, Priori, Roberta, Riccieri, Valeria, Sabatinelli, Danilo, Spinelli, FRANCESCA ROMANA, Truglia, Simona, Valesini, Guido, Vomero, Marta   +16 more
core   +1 more source

The extensive glycosylation of the ACPA variable domain observed for ACPA-IgG is absent from ACPA-IgM

Annals of the Rheumatic Diseases, 2018
Recently, we described the presence of highly sialylated N -linked glycans in the antigen-binding fragment (Fab) of almost all anti-citrullinated protein antibody (ACPA) IgG molecules.1 2 These glycans could not be found on several other autoantibody systems analysed.
Kempers, Ayla C.; Hafkenscheid, Lise; Dorjee, Annemarie L.; Moutousidou, Eleni; van de Bovenkamp, Fleur S.; Rispens, Theo; Trouw, Leendert A.; van Oosterhout, Maikel; Huizinga, Tom W. J.; Toes, Rene; Scherer, Hans Ulrich   +11 more
openaire   +6 more sources

Memories of Past Presidents

Journal of College Orientation, Transition, and Retention, 2007
Six of NODA's past presidents shared their thoughts about NODA's history in a recent leadership survey compiled by Maria Sedotti of the University of Connecticut.
Denise L. Rode
doaj   +1 more source

Effect of Etanercept on anti-carbamylated protein antibodies in patients with rheumatoid arthritis [PDF]

, 2015
Rheumatoid Arthritis (RA) is a systemic, chronic inflammatory disease characterized by inflammation of synovial joints and production of autoantibodies such as Rheumatoid Factor and antibodies directed against modified proteins - i.e.
Alessandri, Cristiano, Ceccarelli, Fulvia, Conti, Fabrizio, Pecani, Arbi, Spinelli, FRANCESCA ROMANA   +4 more
core   +1 more source