The ACPA recognition profile and subgrouping of ACPA-positive RA patients
Annals of the Rheumatic Diseases, 2012 Anticitrullinated protein antibodies (ACPA) are the most predictive factor for the development of rheumatoid arthritis (RA). Epitope spreading towards more citrullinated epitopes occurs before the onset of RA. Here, the authors investigated whether specific epitope recognition allows the identification of specific RA subgroups and whether it is ...
Willemze, A. +9 more
openaire +4 more sources
Satisfaction, Restriction and Amalgamation of Constraints in the Framework of M-Adhesive Categories [PDF]
, 2012 Application conditions for rules and constraints for graphs are well-known in the theory of graph transformation and have been extended already to M-adhesive transformation systems.
Ehrig, Hartmut +4 more
core +3 more sources
Immunopathogenesis of rheumatoid arthritis [PDF]
, 2017 Rheumatoid arthritis (RA) is the most common inflammatory arthropathy. The majority of evidence, derived from genetics, tissue analyses, models, and clinical studies, points to an immune-mediated etiology associated with stromal tissue dysregulation that
Ahmed +115 more
core +1 more source
Association between inflammatory cytokines and immune-checkpoint molecule in rheumatoid arthritis.
PLoS ONE, 2021 BackgroundAnti-citrullinated peptide antibodies (ACPA) and inflammatory cytokines play important roles in the development of rheumatoid arthritis (RA). T cell immunoglobulin and mucin-domain containing-3 (TIM-3) is an immune-checkpoint molecule involved ...
Haruki Matsumoto +13 more
doaj +2 more sources
Frontiers in Oral Health, 2022 IntroductionThe relation between rheumatoid arthritis (RA) and periodontitis (PD) has been investigated ever since the discovery of the citrullinating enzyme peptidyl arginine deaminase presents in the oral bacterium Porphyromonas gingivalis.
Menke J. de Smit +8 more
doaj +1 more source
Structure - property relationships of new polystyrene nanocomposites prepared from initiator-containing layered double hydroxides of zinc aluminum and magnesium aluminum [PDF]
, 2009 Polystyrene/layered double hydroxides (PS/LDHs) nanocomposites were prepared by free radical polymerization of styrene monomer in the presence of LDHs intercalated with 4,4′-azobis(4-cyanopentanoate) anions (LDH–ACPA).
Chen, Dan +3 more
core +2 more sources
Citrullinated vimentin as an important antigen in immune complexes from synovial fluid of rheumatoid arthritis patients with antibodies against citrullinated proteins [PDF]
, 2010 Introduction: Rheumatoid arthritis (RA) is an inflammatory disease, which results in destruction of the joint. The presence of immune complexes (IC) in serum and synovial fluid of RA patients might contribute to this articular damage through different ...
De Ceuleneer, Marlies +5 more
core +3 more sources
Acta Medica Martiniana, 2017 Background: Anti-citrullinated peptides antibodies (ACPA) are specific for rheumatoid arthritis and have been implicated in disease pathogenesis. ACPA examination is a new component of ACR/EULAR 2010 classification criteria for rheumatoid arthritis. ACPA
Belakova Gabriela +3 more
doaj +1 more source
RMD Open, 2022 Background Rheumatoid factor (RF) and anti-citrullinated protein/peptide antibodies (ACPA) are important biomarkers for diagnosis of rheumatoid arthritis (RA). However, there is poor harmonisation of RF and ACPA assays.
Lieve Van Hoovels +29 more
doaj +1 more source
Quantification of IFNγ- and IL17-producing cells after stimulation with citrullinated proteins in healthy subjects and RA patients [PDF]
, 2013 Antibodies against citrullinated proteins are highly specific for rheumatoid arthritis (RA) and are currently used as a diagnostic marker. In this study, we wanted to quantify the numbers of T cells that react to a wide range of citrullinated proteins in
De Ceuleneer, Marlies +5 more
core +1 more source