Results 71 to 80 of about 3,156,736 (262)

Gut Microbiota‐Derived Indole‐3‐Propionic Acid Alleviates Diabetic Osteoporosis Through Nrf2‐Mediated Ferroptosis Suppression

Advanced Science, EarlyView.
Diabetes‐associated dysbiosis is accompanied by reduced Clostridium abundance, impaired microbial tryptophan metabolism, and lower circulating indole‐3‐propionic acid (IPA). Exogenous IPA improves trabecular microarchitecture and bone formation and restores Nrf2‐associated antioxidant signaling in bone marrow mesenchymal stem cells, limiting iron ...
Jinwu Bai, Qinyong You, Gao Si, Daole Hu, Ao Sun, Shilong Su, Ruideng Wang, Jixing Fan, Shan Gao, Tengjiao Zhu, Chun‐Li Song, Fang Zhou, Yang Lv   +12 more
wiley   +1 more source

Risk Factors for 30-Day Mortality of Community-Acquired Bloodstream Infection Patients in Changsha City, Hunan Province, China

Infection and Drug Resistance
Purpose To analyze the factors affecting patients’ prognoses based on the community acquired-bloodstream infection patient data from 2017 to 2021. Patients and Methods The data of 940 patients were retrieved, having at least one positive bilateral blood ...
Linqi Li, Jing Cao, Jiao Qin, Xiang-Xiang Chen, Feng Yuan, P. Deng, He-Bin Xie   +6 more
semanticscholar   +1 more source

Glucocorticoid treatment in community-acquired pneumonia

, 2011
Glucocorticoid treatment in community-acquired ...
Meduri, G. Umberto, Confalonieri, Marco, Marco Confalonieri, G Umberto Meduri   +3 more
core   +1 more source

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

Advanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang, Qi Jiang, Lian Han, Yue Peng, Xingyu Liu, Tong Yang, Hao Huang, Jiaying Liu, Yuan Gao, Hui Yang, Wenjun Zou, Zhaohuai Li, Wenru Su   +12 more
wiley   +1 more source

Investigating crosstalk in lipid rafts between the glucocorticoid receptor and gonadotropin-releasing hormone receptor signaling pathways in a gonadotrope cell line [PDF]

, 2010
Includes abstract.Includes bibliographical references (leaves 121-158).A recent study from the Hapgood laboratory demonstrated the presence of a novel crosstalk mechanism between the glucocorticoid receptor (GR) and gonadotropin-releasing hormone ...
Wehmeyer, Lance
core   +1 more source

SAV1 in Cooperation With FKBP52 Participates in Implantation

Advanced Science, EarlyView.
The MST‐SAV1 complex modulates FKBP52 phosphorylation to fine‐tune PR activity, ensuring timely uterine transition to receptivity under estrogen signaling for implantation. Stromal SAV1 scaffolds MST1/2‐mediated FKBP52 phosphorylation via noncanonical Hippo to promote PR activity.
Yuhan Shao, Yafang Lu, Zhaoyu Jia, Junxiang Ren, Ziyi Ge, Xinyu Liu, Hui Zhao, Zi‐Jiang Chen, Junhao Yan, Wei Wang, Jia Yuan   +10 more
wiley   +1 more source

Assembled Hyaluronic Acid Therapeutics for Targeting M1 Macrophages and Regulating Immune Homeostasis for Ulcerative Colitis Treatment

Advanced Science, EarlyView.
An orally administered, drug‐free hyaluronic acid nanoassembly, uhNAs‐OA, accumulates in the inflamed colon and is preferentially internalized by M1‐like macrophages via HA‐CD44 interactions. uhNAs‐OA scavenges excess ROS, suppresses NF‐κB signaling and remodels the colonic immune landscape, resulting in robust therapeutic efficacy in acute, chronic ...
Jianqin Wan, Andi Ma, Yiqiong Zhang, Minghao Zhang, Yifeng Lin, Xiaoling Zhang, Hongjun Li, Weidong Han   +7 more
wiley   +1 more source

Bioenergetic Materials for Tissue Regeneration: Modulating Metabolism to Promote Cellular Anabolism

Advanced Science, EarlyView.
Bioenergetic materials (BEMs) modulate cellular metabolism to promote tissue regeneration. Their principal mechanisms of action include metabolic substrate supplementation, metabolic enzyme modulation, organelle transfer, electrical current regulation, redox homeostasis modulation, and oxygen tension modulation.
Yuchen He, Yuwen Wang, Jonathan F. Gong, Yiting Lei, Fei Jin, Weihong Zhu, Rocky S. Tuan, Zhong Alan Li   +7 more
wiley   +1 more source

Glucocorticoid-induced insulin resistance in men is associated with suppressed undercarboxylated osteocalcin

, 2019
In mice, glucocorticoid-induced insulin resistance occurs largely through impaired osteoblast function and decreased circulating undercarboxylated osteocalcin (ucOC).
Nigel K Stepto (13451628), Xuzhu Lin (13474225), Tara C Brennan-Speranza (13474228), David L Hare (13557031), Peter R Ebeling (13449258), Elizabeth Byrnes (13590904), Lewan Parker (13081047), Ego Seeman (13573153), Glenn McConell (13560532), Itamar Levinger (489292), Andrew Garnham (13056777)   +10 more
core  

T‐Cell Remodeling in Renal Fibrosis: From Acute Injury to Chronic Kidney Disease

Advanced Science, EarlyView.
This Review presents renal fibrosis as a sequence of overlapping T‐cell programs, from chemokine‐guided recruitment and metabolic activation to maladaptive polarization, tertiary lymphoid structure formation, tissue residency, exhaustion, and senescence.
Qianhui Li, Junting Guan, Yifan Song, Hongxia Yang, Guangtao Li, Xiaodong Zhao, Jiaxin Liu, Bin Liu, Yang Tan, Honglan Zhou, Yang‐He Zhang, Yishu Wang   +11 more
wiley   +1 more source