Th17 Cells, Glucocorticoid Resistance, and Depression [PDF]
Cells, 2023 Depression is a severe mental disorder that disrupts mood and social behavior and is one of the most common neuropsychological symptoms of other somatic diseases.
Julia N. Khantakova +3 more
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Calpeptin may reverse glucocorticoid-resistance of allergic rhinitis associated with cigarette smoke exposure by down-regulating interferon regulatory factor 1 [PDF]
Heliyon, 2023 Cigarette smoke exposure is an important factor in chronic inflammation in patients with allergic rhinitis (AR); however, the relationship between cigarette smoke and AR-related glucocorticoid resistance requires further study.
Wen-Xuan Zhu +10 more
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Convergence of endothelial dysfunction, inflammation and glucocorticoid resistance in depression-related cardiovascular diseases [PDF]
BMC ImmunologyMajor Depressive Disorder, or depression, has been extensively linked to dysregulated HPA axis function, chronic inflammation and cardiovascular diseases.
Zachary Hage +3 more
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Long-Term Cigarette Smoke Exposure Promotes Neutrophil Ferroptosis Resistance, Inducing Neutrophil Extracellular Trap Formation and Driving Glucocorticoid Resistance in Chronic Obstructive Pulmonary Disease [PDF]
ResearchGlucocorticoid resistance increases the frequency of acute exacerbations and the risk of death in chronic obstructive pulmonary disease (COPD) patients with a history of long-term heavy smoking.
Lu Wang +5 more
doaj +2 more sources
Ozone-Induced Oxidative Stress, Neutrophilic Airway Inflammation, and Glucocorticoid Resistance in Asthma [PDF]
Frontiers in Immunology, 2021 Despite recent advances in using biologicals that target Th2 pathways, glucocorticoids form the mainstay of asthma treatment. Asthma morbidity and mortality remain high due to the wide variability of treatment responsiveness and complex clinical ...
Chioma Enweasor +2 more
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Q&A: Primary generalized glucocorticoid resistance [PDF]
BMC Medicine, 2011 What biological processes underlie this “resistance” to cortisol? Because this resistance includes the hypothalamicpituitary-adrenal (HPA) axis negative feedback regulatory centers in the brain and pituitary gland, this axis is activated to “overcome” or compensate for the glucocorticoid action defect (Figure 1).
Chrousos George
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Dasatinib overcomes glucocorticoid resistance in B-cell acute lymphoblastic leukemia [PDF]
Nature Communications, 2023 Resistance to glucocorticoids (GC) is associated with an increased risk of relapse in B-cell progenitor acute lymphoblastic leukemia (BCP-ALL). Performing transcriptomic and single-cell proteomic studies in healthy B-cell progenitors, we herein identify ...
Jolanda Sarno +11 more
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Glucocorticoid resistance conferring mutation in the C-terminus of GR alters the receptor conformational dynamics [PDF]
Scientific Reports, 2021 The glucocorticoid receptor is a key regulator of essential physiological processes, which under the control of the Hsp90 chaperone machinery, binds to steroid hormones and steroid-like molecules and in a rather complicated and elusive response ...
Anna Kaziales +2 more
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Effect of combining glucocorticoids with Compound A on glucocorticoid receptor responsiveness in lymphoid malignancies [PDF]
, 2018 Glucocorticoids (GCs) are a cornerstone in the treatment of lymphoid malignancies such as multiple myeloma (MM) and acute lymphoblastic leukemia (ALL).
Beck, Ilse +5 more
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Nature Communications, 2023 The classical dogma of glucocorticoid-induced insulin resistance is that it is caused by the transcriptional activation of hepatic gluconeogenic and insulin resistance genes by the glucocorticoid receptor (GR).
Rebecca A. Lee +9 more
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