Th17 Cells, Glucocorticoid Resistance, and Depression [PDF]
Cells, 2023 Depression is a severe mental disorder that disrupts mood and social behavior and is one of the most common neuropsychological symptoms of other somatic diseases.
Julia N. Khantakova +3 more
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Calpeptin may reverse glucocorticoid-resistance of allergic rhinitis associated with cigarette smoke exposure by down-regulating interferon regulatory factor 1 [PDF]
Heliyon, 2023 Cigarette smoke exposure is an important factor in chronic inflammation in patients with allergic rhinitis (AR); however, the relationship between cigarette smoke and AR-related glucocorticoid resistance requires further study.
Wen-Xuan Zhu +10 more
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Convergence of endothelial dysfunction, inflammation and glucocorticoid resistance in depression-related cardiovascular diseases [PDF]
BMC ImmunologyMajor Depressive Disorder, or depression, has been extensively linked to dysregulated HPA axis function, chronic inflammation and cardiovascular diseases.
Zachary Hage +3 more
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Long-Term Cigarette Smoke Exposure Promotes Neutrophil Ferroptosis Resistance, Inducing Neutrophil Extracellular Trap Formation and Driving Glucocorticoid Resistance in Chronic Obstructive Pulmonary Disease [PDF]
ResearchGlucocorticoid resistance increases the frequency of acute exacerbations and the risk of death in chronic obstructive pulmonary disease (COPD) patients with a history of long-term heavy smoking.
Lu Wang +5 more
doaj +2 more sources
Ozone-Induced Oxidative Stress, Neutrophilic Airway Inflammation, and Glucocorticoid Resistance in Asthma [PDF]
Frontiers in Immunology, 2021 Despite recent advances in using biologicals that target Th2 pathways, glucocorticoids form the mainstay of asthma treatment. Asthma morbidity and mortality remain high due to the wide variability of treatment responsiveness and complex clinical ...
Chioma Enweasor +2 more
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Current concepts in glucocorticoid resistance
Steroids, 2012 Glucocorticoids (GCs) are the most potent anti-inflammatory agents known. A major factor limiting their clinical use is the wide variation in responsiveness to therapy. The high doses of GC required for less responsive patients means a high risk of developing very serious side effects. Variation in sensitivity between individuals can be due to a number
Nan Yang, David W. Ray, Laura C Matthews
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Mechanisms of glucocorticoid resistance in hypereosinophilic syndromes. [PDF]
Clin Exp Allergy, 2019 Abstract Glucocorticoids (GC) are anti-inflammatory agents commonly used to treat patients with hypereosinophilic syndrome (HES). GC promote eosinophil apoptosis and downregulation of Th2 cytokine production. Although abnormalities of GC receptor (GR) function and elevations in β-GR isoforms have been implicated in GC resistance in ...
Stokes K +8 more
europepmc +4 more sources
Primary Generalized Glucocorticoid Resistance and Hypersensitivity Syndromes: A 2021 Update [PDF]
International Journal of Molecular Sciences, 2021 Nicolas C Nicolaides
exaly +2 more sources
Glucocorticoid Resistance: Interference between the Glucocorticoid Receptor and the MAPK Signalling Pathways [PDF]
International Journal of Molecular Sciences, 2021 Lisa M Sevilla +2 more
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Nature Communications, 2023 The classical dogma of glucocorticoid-induced insulin resistance is that it is caused by the transcriptional activation of hepatic gluconeogenic and insulin resistance genes by the glucocorticoid receptor (GR).
Rebecca A. Lee +9 more
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