Results 21 to 30 of about 126,176 (294)

Narrative Review: Glucocorticoids in Alcoholic Hepatitis—Benefits, Side Effects, and Mechanisms

Journal of Xenobiotics, 2022
Alcoholic hepatitis is a major health and economic burden worldwide. Glucocorticoids (GCs) are the only first-line drugs recommended to treat severe alcoholic hepatitis (sAH), with limited short-term efficacy and significant side effects. In this review,
Hong Lu
doaj   +1 more source

Glucocorticoid Receptor and Adipocyte Biology. [PDF]

, 2018
Glucocorticoids are steroid hormones that play a key role in metabolic adaptations during stress, such as fasting and starvation, in order to maintain plasma glucose levels.
Harris, Charles A, Lee, Rebecca A, Wang, Jen-Chywan   +2 more
core   +2 more sources

An unexpected, mild phenotype of glucocorticoid resistance associated with glucocorticoid receptor gene mutation case report and review of the literature

BMC Medical Genetics, 2018
Background Glucocorticoid resistance is a rare, sporadic or familial condition caused by mutation of the gene encoding the glucocorticoid receptor (GR).
Ágnes Molnár, Attila Patócs, István Likó, Gábor Nyírő, Károly Rácz, Miklós Tóth, Beatrix Sármán   +6 more
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11 beta-hydroxysteroid dehydrogenase type 1 regulates glucocorticoid-induced insulin resistance in skeletal muscle [PDF]

, 2009
OBJECTIVE: Glucocorticoid excess is characterized by increased adiposity, skeletal myopathy, and insulin resistance, but the precise molecular mechanisms are unknown.
A. Yu, Abdallah, Aguirre, Araki, C. Lenaghan, D. Laber, D. M. Smith, Danielsson, Djurhuus, Draznin, Fraser, G. Convey, G. G. Lavery, Geraghty, Giorgino, Giorgino, Giorgino, Hanada, I. J. Bujalska, J. K. Sethi, J. W. Tomlinson, Jang, K. Hegyi, Kido, Kim, L. L. Gathercole, Larsson, Liu, M. Sherlock, M  ssig, P. M. Stewart, R. Mayers, S. A. Morgan, Saad, van Staa, Watson, Whorwood, Zhang   +37 more
core   +3 more sources

Clinical aspects of glucocorticoid sensitivity [PDF]

, 1996
Recent studies demonstrate that primary (hereditary) abnormalities in the glucocorticoid receptor gene make 6.6% of the normal population relatively 'hypersensitive' to glucocorticoids, while 2.3% are relatively 'resistant.' These abnormalities might ...
Huizenga, N.A.T.M. (Nannette), Jong, F.H. (Frank) de, Koper, J.W. (Jan), Lamberts, S.W.J. (Steven), Lange, P. (Pieter) de   +4 more
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Thioredoxin-1: A Promising Target for the Treatment of Allergic Diseases

Frontiers in Immunology, 2022
Thioredoxin-1 (Trx1) is an important regulator of cellular redox homeostasis that comprises a redox-active dithiol. Trx1 is induced in response to various stress conditions, such as oxidative damage, infection or inflammation, metabolic dysfunction ...
Jinquan Wang, Jiedong Zhou, Cuixue Wang, Atsushi Fukunaga, Shujing Li, Junji Yodoi, Hai Tian, Hai Tian   +7 more
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Overcoming steroid resistance in T cell acute lymphoblastic leukemia [PDF]

, 2016
In a Perspective, Pieter Van Vlierberghe and Steven Goossens discuss Meijerink and colleagues' findings on steroid resistance in pediatric T cell acute lymphoblastic ...
Goossens, Steven, Van Vlierberghe, Pieter   +1 more
core   +3 more sources

GLCCI1 Deficiency Induces Glucocorticoid Resistance via the Competitive Binding of IRF1:GRIP1 and IRF3:GRIP1 in Asthma

Frontiers in Medicine, 2021
GLCCI1 plays a significant role in modulating glucocorticoid (GC) sensitivity in asthma. This project determines the underlying mechanism that GLCCI1 deficiency attenuates GC sensitivity in dexamethasone (Dex)-treated Ovalbumin (OVA)-induced asthma mice ...
Xinyue Hu, Shuanglinzi Deng, Lisha Luo, Yuanyuan Jiang, Huan Ge, Feifei Yin, Yingyu Zhang, Daimo Zhang, Xiaozhao Li, Juntao Feng   +9 more
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A novel human glucocorticoid receptor SNP results in increased transactivation potential. [PDF]

, 2017
Glucocorticoids are one of the most widely used therapeutics in the treatment of a variety of inflammatory disorders. However, it is known that there are variable patient responses to glucocorticoid treatment; there are responders and non-responders, or ...
Cho, Kiho, Green, Tajia L, Greenhalgh, David G, Leventhal, Stacey M, Lim, Debora, Tung, Kelly   +5 more
core   +3 more sources

Integrated bioinformatics analysis of the crucial candidate genes and pathways associated with glucocorticoid resistance in acute lymphoblastic leukemia

Cancer Medicine, 2020
Glucocorticoids (GC) are the foundation of the chemotherapy regimen in acute lymphoblastic leukemia (ALL). However, resistance to GC is observed more frequently than resistance to other chemotherapy agents in patients with ALL relapse.
Yanxin Chen, Peifang Jiang, Jingjing Wen, Zhengjun Wu, Jiazheng Li, Yuwen Chen, Lingyan Wang, Donghui Gan, Yingyu Chen, Ting Yang, Minhui Lin, Jianda Hu   +11 more
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