Results 31 to 40 of about 2,312,594 (289)

Integrated bioinformatics analysis of the crucial candidate genes and pathways associated with glucocorticoid resistance in acute lymphoblastic leukemia

Cancer Medicine, 2020
Glucocorticoids (GC) are the foundation of the chemotherapy regimen in acute lymphoblastic leukemia (ALL). However, resistance to GC is observed more frequently than resistance to other chemotherapy agents in patients with ALL relapse.
Yanxin Chen, Peifang Jiang, Jingjing Wen, Zhengjun Wu, Jiazheng Li, Yuwen Chen, Lingyan Wang, Donghui Gan, Yingyu Chen, Ting Yang, Minhui Lin, Jianda Hu   +11 more
doaj   +1 more source

Changes in Functional Glucocorticoid Sensitivity of Isolated Splenocytes Induced by Chronic Psychosocial Stress – A Time Course Study

Frontiers in Immunology, 2021
Chronic psychosocial stress is a risk factor for the development of numerous disorders, of which most are associated with chronic low-grade inflammation.
Elena Kempter, Mattia Amoroso, Hannah L. Duffner, Andrea M. Werner, Dominik Langgartner, Sandra Kupfer, Stefan O. Reber   +6 more
doaj   +1 more source

Circadian and Ultradian Rhythms of Free Glucocorticoid Hormone Are Highly Synchronized between the Blood, the Subcutaneous Tissue, and the Brain [PDF]

, 2012
Total glucocorticoid hormone levels in plasma of various species, including humans, follow a circadian rhythm that is made up from an underlying series of hormone pulses. In blood most of the glucocorticoid is bound to corticosteroid-binding globulin and
Linthorst, Astrid C E, Droste, Susanne K, Reul, Johannes M H M, Qian, Xiaoxiao, Lightman, Stafford L   +4 more
core   +1 more source

Mixed-model QSAR at the glucocorticoid and liver X receptors [PDF]

, 2009
The presence of hormonally active compounds in the biosphere has become a worldwide environmental concern, and measures such as policy acts and regulations try to address the problem, both in Europe and in the United States.
Spreafico, Morena
core   +1 more source

Selective non-steroidal glucocorticoid receptor agonists attenuate inflammation but do not impair intestinal epithelial cell restitution in vitro [PDF]

, 2012
Introduction: Despite the excellent anti-inflammatory and immunosuppressive action of glucocorticoids (GCs), their use for the treatment of inflammatory bowel disease (IBD) still carries significant risks in terms of frequently occurring severe side ...
Kerstin C Reuter, Jürgen Stein, Axel U Dignass, Stefan M Loitsch, Dieter Steinhilber (182458), Reuter, Kerstin C., Dignaß, Axel Uwe, Kerstin C. Reuter (186426), Dieter Steinhilber, Stefan M. Loitsch (186433), Loitsch, Stefan Marcel, Stein, Jürgen, Axel U. Dignass (186440), Steinhilber, Dieter, Jürgen Stein (186447)   +14 more
core   +2 more sources

Application of glucocorticoids in patients with novel coronavirus infection: From bench to bedside

Traditional Medicine and Modern Medicine, 2020
Glucocorticoids (GCs) have potential anti-inflammatory and immunosuppressive effects. There is plenty of controversy about the application of glucocorticoids in the treatment of coronavirus disease 2019 (COVID-19).
Linwei Lu, Jianhua Huang, Xiaohong Deng, Xianjun Sun, Jingcheng Dong   +4 more
doaj   +1 more source

Narrative Review: Glucocorticoids in Alcoholic Hepatitis—Benefits, Side Effects, and Mechanisms

Journal of Xenobiotics, 2022
Alcoholic hepatitis is a major health and economic burden worldwide. Glucocorticoids (GCs) are the only first-line drugs recommended to treat severe alcoholic hepatitis (sAH), with limited short-term efficacy and significant side effects. In this review,
Hong Lu
doaj   +1 more source

NALP3 inflammasome upregulation and CASP1 cleavage of the glucocorticoid receptor cause glucocorticoid resistance in leukemia cells [PDF]

, 2015
Glucocorticoids are universally used in the treatment of acute lymphoblastic leukemia (ALL), and resistance to glucocorticoids in leukemia cells confers poor prognosis.
Relling M. V., Mayasundari A., Den Boer M. L., McCorkle J. R., Zanut A., Panetta J. C., Jeha S., Min J., Mullighan C. G., Carroll W. L., Wilkinson M. R., Latif F., Karol S. E., Giordanengo A., Yang W., Myers R. M., Malireddi R. K. S., Ferreira A. M., Pieters R., Bonten E. J., Cheng C., Hicks J. K., Smith C., Holmfeldt L., Dunwell T. L., Kanneganti T. -D., Savic D., Actis M., Stocco G., Ramsey L. B., Bianchi J. J., Crona D., Thierfelder W. E., Crews K. R., Pui C. -H., Evans W. E., Paugh S. W., Diouf B., Guy R. K., Coss D. R., Bhojwani D., Gurung P., Fernandez C. A., Laudermilk L. T., Fan Y.   +44 more
core   +2 more sources

An investigation into the role of acetylation and ligand-dependent nuclear localisation in glucocorticoid receptor transcriptional regulation [PDF]

, 2010
Includes bibliographical references (leaves 134-151).The glucocorticoid receptor (GR) is a ligand-activated transcription factor which, due to its central role in anti-inflammatory responses, is a target of many therapeutically prescribed drugs.
Hadley, Katie Emma
core   +1 more source

SIRT1: potential target in glucocorticoid-resistant diseases

Frontiers in Immunology
Glucocorticoid resistance is a challenging problem in clinical practice. Increasing glucocorticoid sensitivity and reducing resistance are important in the management of certain diseases.
Jun Xie, Siyi Che, Jiao Liu, Xiaoru Long
doaj   +1 more source