Results 31 to 40 of about 126,176 (294)
Frontiers in Oncology, 2021 Childhood acute lymphoblastic leukaemia (cALL) accounts for about one third of all paediatric malignancies making it the most common cancer in children.
Yordan Sbirkov +11 more
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, 2019 Primary generalized glucocorticoid resistance or Chrousos syndrome is a rare disorder, which affects all tissues expressing the human glucocorticoid receptor. It is characterized by generalized, partial tissue insensitivity to glucocorticoids caused by genetic defects in the NR3C1 gene.
Nicolaides, N.C., Charmandari, E.
openaire +3 more sources
Glucocorticoid receptor expression in 20 solid tumor types using immunohistochemistry assay. [PDF]
, 2017 BackgroundGlucocorticoid receptor (GR) activity plays a role in many aspects of human physiology and may play a crucial role in chemotherapy resistance in a wide variety of solid tumors.
Block, Thaddeus S +4 more
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The Glucocorticoid Receptor: A Revisited Target for Toxins
Toxins, 2010 The hypothalamic-pituitary-adrenal (HPA) axis activation and glucocorticoid responses are critical for survival from a number of bacterial, viral and toxic insults, demonstrated by the fact that removal of the HPA axis or GR blockade enhances mortality ...
Jeanette I. Webster Marketon +1 more
doaj +1 more source
Glucocorticoids in Sepsis: To Be or Not to Be
Frontiers in Immunology, 2020 Sepsis is a highly lethal syndrome resulting from dysregulated immune and metabolic responses to infection, thereby compromising host homeostasis. Activation of the hypothalamic–pituitary–adrenal (HPA) axis and subsequently adrenocortical glucocorticoid (
Jolien Vandewalle +3 more
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Glucocorticoid receptor action in metabolic and neuronal function [version 1; referees: 3 approved] [PDF]
, 2017 Glucocorticoids via the glucocorticoid receptor (GR) have effects on a variety of cell types, eliciting important physiological responses via changes in gene expression and signaling.
Garabedian, Michael J +2 more
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Frontiers in Endocrinology, 2020 Cushing's disease is characterized by excessive adrenocorticotropin hormone (ACTH) secretion caused by a corticotroph tumor of the pituitary gland, leading to hypercortisolism and increased morbidity and mortality. The molecular causes of the disease are
Denis Ciato, Adriana Albani
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LPS resistance of SPRET/Ei mice is mediated by Gilz, encoded by the Tsc22d3 gene on the X chromosome [PDF]
, 2013 Natural variation for LPS-induced lethal inflammation in mice is useful for identifying new genes that regulate sepsis, which could form the basis for novel therapies for systemic inflammation in humans.
Beaulieu E +12 more
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Glucocorticoid receptor alpha as a core survival receptor: mechanisms, and implications for health and critical illness [PDF]
Exploration of Endocrine and Metabolic DiseasesThe glucocorticoid receptor alpha (GRα) is traditionally viewed as a stress-response element with anti-inflammatory properties. Mechanistically, convergent evidence from global and tissue-specific knockout models, translational clinical studies, and ...
G. Umberto Meduri
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Glucocorticoid-resistant Bronchial Asthma [PDF]
Medical Journal Armed Forces India, 2004 Glucocorticoids have potent anti-inflammatory actions and are most effective agents in the treatment of bronchial asthma. However, a subset of asthmatic patients do not benefit from glucocorticoid therapy. Management of these patients with glucocorticoid resistant bronchial asthma presents unique challenges because of lack of effective and well ...
openaire +2 more sources