Results 41 to 50 of about 2,312,594 (289)

Abnormality of Aldosterone and Cortisol Late Pathways in Glucocorticoid-Remediable Aldosteronism. [PDF]

, 1994
Patients with glucocorticoid-remediable aldosteronism (GRA) possess a chimeric gene resulting from fusion of the genes encoding steroid aldosterone synthase and 11 beta-hydroxylase.
Boscaro, Marco, Kuhnle, Ursula, KUHNLE U, Fallo, Francesco, Sonino, Nicoletta   +4 more
core   +1 more source

Glucocorticoid receptor alpha as a core survival receptor: mechanisms, and implications for health and critical illness [PDF]

Exploration of Endocrine and Metabolic Diseases
The glucocorticoid receptor alpha (GRα) is traditionally viewed as a stress-response element with anti-inflammatory properties. Mechanistically, convergent evidence from global and tissue-specific knockout models, translational clinical studies, and ...
G. Umberto Meduri
doaj   +1 more source

The role of glucocorticoid action in the pathophysiology of the Metabolic Syndrome

Nutrition & Metabolism, 2005
Glucocorticoids are stress hormones that modulate a large number of physiological actions involved in metabolic, inflammatory, cardiovascular and behavioral processes.
Wang Minghan
doaj   +1 more source

Alendronate or alfacalcidol in glucocorticoid-induced osteoporosis [PDF]

, 2006
BACKGROUND: Treatment with glucocorticoids is associated with bone loss starting soon after therapy is initiated and an increased risk of fracture. METHODS: We performed a randomized, double-placebo, double-blind clinical trial of 18 months' duration ...
Buskens, E.; id_orcid, Jacobs, J.W.G., Laan, R.F., Laan, R.F.J.M., Oostveen, A.C., Lems, W.F., Dijkmans, B.A., Bruyn, G.A.W., Huisman, A.M., Jacobs, J.W., Hofbauer, L.C., Laet, C.E. de, Algra, A., Dijkmans, B.A.C., de Laet, C.E.D., Bruyn, G.A., Geusens, P.P., de Nijs, R.N., Buskens, E., Bijlsma, J.W., Bijlsma, J.W.J., Geusens, P.P.M.M., Laan, R.F.J., Huisman, A., Nijs, R.N. de, Oostveen, A.C.M., de Nijs, R.N.J.   +26 more
core   +4 more sources

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Extra-adrenal regeneration of glucocorticoids by 11beta-hydroxysteroid dehydrogenase type 1:physiological regulator and pharmacological target for energy partitioning [PDF]

, 2007
The major glucocorticoid in man, cortisol, plays important roles in regulating fuel metabolism, energy partitioning and body fat distribution.
Walker, Brian R
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Glucocorticoids in Sepsis: To Be or Not to Be

Frontiers in Immunology, 2020
Sepsis is a highly lethal syndrome resulting from dysregulated immune and metabolic responses to infection, thereby compromising host homeostasis. Activation of the hypothalamic–pituitary–adrenal (HPA) axis and subsequently adrenocortical glucocorticoid (
Jolien Vandewalle, Jolien Vandewalle, Claude Libert, Claude Libert   +3 more
doaj   +1 more source

Polycystic ovary syndrome in a patient with type B insulin resistance syndrome can improve with glucocorticoid treatment: a case report and literature review

Endocrine Journal, 2023
Polycystic ovary syndrome (PCOS) frequently exhibits hyperinsulinemia due to insulin resistance, but there are many unknown aspects of this disease. This report presents the case of a 31-year-old woman with PCOS and type B insulin resistance syndrome ...
Tetsuhiro Watanabe, Saori Okabe, Shohei Sakamoto   +2 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source