Results 11 to 20 of about 126,176 (294)

NALP3 inflammasome upregulation and CASP1 cleavage of the glucocorticoid receptor cause glucocorticoid resistance in leukemia cells [PDF]

Nature Genetics, 2015
Glucocorticoids are universally used in the treatment of acute lymphoblastic leukemia (ALL), and resistance to glucocorticoids in leukemia cells confers poor prognosis.
A Holleman, Alessandra Zanut, Anand Mayasundari, Antonio M Ferreira, AR Shenoy, Audrey Giordanengo, B Lu, Barthelemy Diouf, CA Ray, CH Pui, CH Pui, Charles G Mullighan, Cheng Cheng, Ching-Hon Pui, Christian A Fernandez, CL Jones, CL Wellington, Colton Smith, D Savic, Daniel Crona, Daniel Savic, David R Coss, Deepa Bhojwani, E Charmandari, E Hubbell, EJ Yeoh, Erik J Bonten, F Martinon, Farida Latif, Gabriele Stocco, GJ Kaspers, J Bouligand, J Kevin Hicks, J Robert McCorkle, Jaeki Min, JC Wang, John C Panetta, Joy J Bianchi, JS Boehm, K Schroder, Kristine R Crews, L Gautier, Laura B Ramsey, LE Hogan, LI McKay, Linda Holmfeldt, Lucas T Laudermilk, M Bialer, M Dördelmann, M Garcia-Calvo, M Karl, M Muzio, Marcelo Actis, Mark R Wilkinson, Mary V Relling, MH Cheok, ML Den Boer, Monique L den Boer, MR Yudt, N Pottier, N Subramanian, PF Kuan, PJ Houghton, Prajwal Gurung, PS Bachmann, PS Bachmann, R K Subbarao Malireddi, R Kiplin Guy, R Pieters, R Zhou, RC Gentleman, RH Shoemaker, Richard M Myers, Rob Pieters, S Mariathasan, S Riml, S Teurich, Seth E Karol, SH Meijsing, Sima Jeha, Steven W Paugh, T Komiyama, TE Reddy, Thirumala-Devi Kanneganti, Thomas L Dunwell, TL Bailey, Wenjian Yang, William E Evans, William E Thierfelder, William L Carroll, X Yang, Y Ogura, Y Zhang, Yiping Fan, Z Michailidou   +94 more
core   +4 more sources

Glucocorticoid Resistance: Is It a Requisite for Increased Cytokine Production in Depression? A Systematic Review and Meta-Analysis

Frontiers in Psychiatry, 2019
Background: Glucocorticoid resistance—reduced function of the glucocorticoid receptor (GR)—is seen in many depressed patients. It is argued that this resistance to glucocorticoids leads to failure of normal feedback regulation on the immune system.
Andrew J. Perrin, Andrew J. Perrin, Mark A. Horowitz, Jacob Roelofs, Patricia A. Zunszain, Carmine M. Pariante   +5 more
doaj   +3 more sources

Emerging Epigenetic and Posttranslational Mechanisms Controlling Resistance to Glucocorticoids in Acute Lymphoblastic Leukemia

HemaSphere, 2023
Glucocorticoids are extensively used for the treatment of acute lymphoblastic leukemia as they pressure cancer cells to undergo apoptosis. Nevertheless, glucocorticoid partners, modifications, and mechanisms of action are hitherto poorly characterized ...
Cristina Borin, Tim Pieters, Valentina Serafin, Panagiotis Ntziachristos   +3 more
doaj   +1 more source

Functional and Structural Impact of Deleterious Missense Single Nucleotide Polymorphisms in the NR3C1, CYP3A5, and TNF-α Genes: An In Silico Analysis

Biomolecules, 2022
Human diseases are generally influenced by SNPs (single nucleotide polymorphisms). The mutations in amino acid residues generated by deleterious SNPs contribute to the structural and functional diversity of the encoded protein.
Navakanth Raju Ramayanam, Ranjani Manickam, Vijayakumar Thangavel Mahalingam, Khang Wen Goh, Chrismawan Ardianto, Poovi Ganesan, Long Chiau Ming, Rajanandh Muhasaparur Ganesan   +7 more
doaj   +1 more source

How the glucocorticoid receptor contributes to platinum-based therapy resistance in solid cancer

Nature Communications, 2021
Synthetic glucocorticoids serve as co-medication against solid malignant tumors. However, glucocorticoid receptor activation may promote unsolicited cancer resistance to chemotherapy.
Dorien Clarisse, Karolien De Bosscher
doaj   +1 more source

Changes in Functional Glucocorticoid Sensitivity of Isolated Splenocytes Induced by Chronic Psychosocial Stress – A Time Course Study

Frontiers in Immunology, 2021
Chronic psychosocial stress is a risk factor for the development of numerous disorders, of which most are associated with chronic low-grade inflammation.
Elena Kempter, Mattia Amoroso, Hannah L. Duffner, Andrea M. Werner, Dominik Langgartner, Sandra Kupfer, Stefan O. Reber   +6 more
doaj   +1 more source

A plant-derived glucocorticoid receptor modulator attenuates inflammation without provoking ligand-induced resistance [PDF]

, 2010
Background: Acquired resistance to glucocorticoids constitutes a major clinical challenge, often overlooked in the search for improved alternatives to classic steroids.
De Bosscher, Karolien, Dewint, Pieter, Elewaut, Dirk, Gossye, Valerie, Haegeman, Guy, Van Beneden, Katrien   +5 more
core   +2 more sources

Glycometabolic Alterations in Secondary Adrenal Insufficiency: Does Replacement Therapy Play a Role? [PDF]

, 2018
Secondary adrenal insufficiency (SAI) is a potentially life-threatening endocrine disorder due to an impairment of corticotropin (ACTH) secretion from any process affecting the hypothalamus or pituitary gland.
Gianfrilli, Daniele, Graziadio, Chiara, Hasenmajer, Valeria, Isidori, Andrea M., Sbardella, Emilia, Venneri, Mary A.   +5 more
core   +6 more sources

Selective glucocorticoid receptor-activating adjuvant therapy in cancer treatments [PDF]

, 2016
Although adverse effects and glucocorticoid resistance cripple their chronic use, glucocorticoids form the mainstay therapy for acute and chronic inflammatory disorders, and play an important role in treatment protocols of both lymphoid malignancies and ...
Beck, Ilse, Bracke, Marc, Clarisse, Dorien, Offner, Fritz, Sundahl, Nora, Vanden Berghe, Wim   +5 more
core   +2 more sources

The glucocorticoid-Angptl4-ceramide axis induces insulin resistance through PP2A and PKCζ. [PDF]

, 2017
Chronic glucocorticoid exposure is associated with the development of insulin resistance. We showed that glucocorticoid-induced insulin resistance was attenuated upon ablation of Angptl4, a glucocorticoid target gene encoding the secreted protein ...
Benjamin, Daniel I, Chen, Tzu-Chieh, Costello, Damian E, Kuo, Taiyi, Lee, Rebecca A, Li, Mei-Lan, Mar, Darryl J, Nomura, Daniel K, Wang, Jen-Chywan   +8 more
core   +1 more source