Results 81 to 90 of about 3,156,736 (262)

Mechanisms of acquired resistance to androgen receptor targeting drugs in castration resistant prostate cancer

Expert Review of Anticancer Therapy, 2014
After initial response to androgen receptor (AR) targeting drugs abiraterone or enzalutamide, most patients develop progressive disease and therefore, castration resistant prostate cancer remains a terminal disease.
D. Chism, Dinuka De Silva, Y. Whang
semanticscholar   +1 more source

LAPTM5 Downregulation‐Driven VAMP8 Phosphorylation Impairs Autophagosome‐Lysosome Fusion and Aggravates Septic Acute Lung Injury

Advanced Science, EarlyView.
LAPTM5 functions as a critical molecular scaffold bridging PGAM5 and VAMP to facilitate PGAM5‐mediated dephosphorylation of VAMP8. This cascade promotes autophagosome‐lysosome fusion, restores impaired autophagic flux, and clears damaged mitochondria, thereby mitigating cellular oxidative stress and systemic inflammation.
Lang Jiang, Qilan Li, Hao Liu, Xuehui Gao, Hongyu Nie, Lang Chen, Mei He, Xuefeng Li, Xiangming Fang, Jiqian Xu, Hao Zhang, Jiahong Xia, You Shang   +12 more
wiley   +1 more source

Yoda1‐Functionalized Nanozymes Coordinate Piezo1 Activation and Mitochondrial Protection to Reprogram the Diabetic Osteoimmune Micromilieu and Promote Vascularized Bone Repair

Advanced Science, EarlyView.
Diabetic bone defects remain a critical clinical challenge. A 3D‐printed BCPG‐MF@Y scaffold, embedding Yoda1‐functionalized manganese dioxide‐ferritin nanozymes, scavenges mtROS, suppresses the cGAS–STING pathway, and reverses cellular senescence, while Yoda1 activates Piezo1 to direct BMSCs fate to synergistically reprogram the osteoimmune ...
Qing‐Song Deng, Ang Wang, Ren Zhang, Xu‐Ran Li, Po‐Lin Liu, Shu‐Hang He, Zi‐Yin Han, Zhi‐Han Shen, Zhan‐Ying Wei, Chang‐Ru Zhang, Fei Wang, Helen Dawes, Jian Lu, Tong‐He Zhu, Jin‐Zhong Zhao, Shang‐Chun Guo, Shi‐Cong Tao   +16 more
wiley   +1 more source

Challenges of drug resistance in the management of pancreatic cancer [PDF]

, 2010
The current treatment of choice for metastatic pancreatic cancer involves single agent gemcitabine or combination of gemcitabine with capecitabine and erlotinib (tyrosine kinase inhibitor).
Naomi Walsh, Martin Clynes, Rizwan Sheikh, Sheikh, Rizwan, O'Connor, Robert A., Robert O’Connor, Ray McDermott, O'Connor, Robert, Clynes, Martin, Walsh, Naomi, McDermott, Ray   +10 more
core   +1 more source

Mitochondrial Quality Control in Degenerative Musculoskeletal Diseases: Signaling Networks and Therapeutic Landscapes

Advanced Science, EarlyView.
Mitochondrial quality control (MQC) collapse redefines osteoarthritis, intervertebral disc degeneration, and osteoporosis as disorders of organelle dysfunction. Damaged mitochondria leak mtDNA and metabolites, driving cGAS‐STING inflammation, epigenetic reprogramming, and metabolic memory.
Haiyang Gao, Zhangrong Cheng, Xianglong Chen, Wenbo Wu, Wang Wu, Zimu Yu, Cao Yang, Yukun Zhang   +7 more
wiley   +1 more source

The aetiopathogenesis, cardiovascular and metabolic complications, and pharmacogenomics of Addison's disease in South Africa [PDF]

, 2011
Includes abstract.Includes bibliographical references.This thesis aimed to address a number of unanswered research questions in Addison's Disease: investigate whether autoimmunity is the predominant cause of Addison's disease in South Africa and if a
Ross, Ian Louis
core   +1 more source

Transcriptional Blood Signatures Distinguish Pulmonary Tuberculosis, Pulmonary Sarcoidosis, Pneumonias and Lung Cancers [PDF]

, 2013
Rationale New approaches to define factors underlying the immunopathogenesis of pulmonary diseases including sarcoidosis and tuberculosis are needed to develop new treatments and biomarkers. Comparing the blood transcriptional response of tuberculosis
Lipman, M, Derek Blankenship, Katalin A Wilkinson, Christine M Graham, Xu, Zhaohui, Vancheeswaran, Rama, Matthew P. R. Berry (130010), Anne O’Garra (130055), Dominique, Valeyre, Beynon, H, Banchereau, J, Rama Vancheeswaran, Guy Gorochov, Virginia Pascual, Anne O'Garra, Ling-pei Ho, Phillip Vanhems, Damien Chaussabel (26369), Pascual, V, Phillip Vanhems (441320), Xu, Z, Yvonne Kendrick (441315), Kendrick, Yvonne, Rozakeas, F, Chloe I. Bloom (130006), Lipman, Marc, Huw Beynon (441321), Vanhems, Phillip, Fotini Rozakeas, Wickremasinghe, Melissa, Christine M. Graham (130008), Miyara, M, Jacques Banchereau, Wickremasinghe, M, Marc Lipman, Matthew P. R. Berry, Diane Bouvry (441317), Yuanyuan Wang, Huw Beynon, Ferry, T, Berry, MP, Blankenship, D, Derek Blankenship (173502), Wilkinson, Robert J, Gilles Devouassoux (441316), Dominique, V, Ferry, Tristan, Paul S. Redford (441314), Robert J. Wilkinson, Berry, MPR, Matthew P R Berry, Melissa Wickremasinghe, Jacques Banchereau (4187), Wilkinson, Katalin A, Valeyre Dominique, Redford, Paul S, Zhaohui Xu, Saadatian, Mitra, Gilles Devouassoux, Berry, Matthew P R, Wang, Y, O\u27Garra, Anne, Yuanyuan Wang (20181), Rama Vancheeswaran (441322), Blankenship, Derek, Vancheeswaran, R, Katalin A. Wilkinson, Saadatian, M, Mitra Saadatian, Paul S. Redford, O'Garra, A, Chaussabel, Damien, Diane Bouvry, Devouassoux, G, Melissa Wickremasinghe (235318), Ho, LP, Robert J Wilkinson, Ho, Ling-Pei, Mitra Saadatian (441319), Guy Gorochov (89307), Wilkinson, KA, Pascual, Virginia, Rozakeas, Fotini, Katalin A. Wilkinson (130012), Robert J. Wilkinson (130050), Zhaohui Xu (130026), Damien Chaussabel, Gorochov, Guy, Graham, CM, Beynon, Huw, Valeyre, D, Tristan Ferry, Tristan Ferry (412308), Redford, PS, Bloom, Chloe I, Virginia Pascual (130037), Bouvry, D, Chaussabel, D, Chloe I. Bloom, Marc Lipman (130043), Vanhems, P, Bloom, CI, Paul S Redford, Chloe I Bloom, Ling-pei Ho (5655859), Wang, Yuanyuan, Yvonne Kendrick, Anne O’Garra, Dominique Valeyre, Gorochov, G, Kendrick, Y, Makoto Miyara, Bouvry, Diane, Banchereau, Jacques, Miyara, Makoto, Valeyre Dominique (441318), Christine M. Graham, Devouassoux, Gilles, Ho, L-P, Wilkinson, RJ, Makoto Miyara (199979), Graham, Christine M, Fotini Rozakeas (130019)   +122 more
core   +1 more source

Chromosomal Abnormalities, Drug Sensitivity and Resistance in Hematological Malignancies: A Comprehensive Overview by the Francophone Group of Hematological Cytogenetics (GFCH)

American Journal of Hematology, EarlyView.
ABSTRACT Chromosomal abnormalities have a major clinical impact on hematological malignancies, particularly with regard to treatment strategies. To preserve and consolidate fundamental knowledge in this rapidly evolving field, the Francophone Group of Hematological Cytogenetics (Groupe Francophone de Cytogénétique Hématologique, GFCH) conducted a ...
Florence Nguyen‐Khac, Audrey Bidet, Elise Chapiro, Nathalie Douet‐Guilbert, Jean‐Baptiste Gaillard, Nada Assaf, Nathalie Auger, Hend Chaker, Jasmine Chauzeix, Inge Govaerts, Hippolyte Guérineau, Christine Lefebvre, Pauline Roynard, Hélène Guermouche, Lucienne Michaux, Marie‐Bérengère Troadec, Lauren Véronèse   +16 more
wiley   +1 more source

A Novel NR3C1 Frameshift Variant Associated With Familial Glucocorticoid Resistance Syndrome: An Integrated Analysis of Steroid Profiling and Structural Modeling

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Glucocorticoid resistance syndrome (GRS) is a rare hereditary disorder caused by pathogenic variants in NR3C1, characterized by marked phenotypic heterogeneity and frequent misdiagnosis as primary aldosteronism or subclinical Cushing's syndrome.
Sufang Yun, Zhifeng Zhu, Fengye Zhou, Ying Liu, Chunfang Liang, Haitao Ju, Lin Lu, Zhaoli Yan   +7 more
wiley   +1 more source

The hypothalamic-pituitary-adrenal axis in critical illness [PDF]

, 1993
Plasma ACTH and cortisol concentrations are frequently elevated in patients in intensive care units (ICU). To examine the functional integrity of the hypothalamic-pituitary-adrenal axis during critical illness, we evaluated prospectively 53 ICU patients ...
Winkelmann, W., Allolio, B., Würth, G., Reincke, Martin   +3 more
core   +1 more source