Results 21 to 30 of about 1,953,005 (139)

Modelling Down Syndrome leukaemia using transchromosomic ES cell lines. [PDF]

, 2009
PhDAMKL (acute megakaryoblastic leukaemia) accounts for at least 50% of all cases of acute myeloid leukaemia (AML) associated with Down Syndrome (DS). Every tenth neonate with DS develops Transient Myeloproliferative Disorder (TMD), a self-regressing
De Vita, Serena
core   +4 more sources

Bilateral Avascular Necrosis of the Femoral Heads in Ankylosing Spondylitis Requiring Staged Total Hip Arthroplasty: A Case Report of Diagnostic and Therapeutic Challenges

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Ankylosing spondylitis (AS) is a chronic immune‐mediated inflammatory arthropathy primarily affecting the axial skeleton but may involve peripheral joints, particularly the hips. Avascular necrosis (AVN) of the femoral head represents a severe, underrecognized complication whose pathogenesis in AS is multifactorial—encompassing disease ...
Syeda Simrah Shah, Muhammad Ahsan, Tehreem Farooq, Mirza Daniyal Baig, Mirza Mohammad Ali Baig, Mohammed Hammad Jaber Amin   +5 more
wiley   +1 more source

SAPHO Syndrome Presenting With Severe Inflammatory Back Pain (Sacroiliitis) and Rare Retinol Associated Myopathy in an Iraqi Adolescent Male: A Case Report and Literature Review

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT SAPHO syndrome is a rare autoinflammatory disorder characterized by synovitis, acne, pustulosis, hyperostosis, and osteitis. Although musculoskeletal and dermatologic manifestations are well recognized, extra‐articular involvement remains uncommon, particularly muscular inflammation.
Farah Jaafar Mahdi, Ali Saad Al‐Shammari, Mustafa Majid Hameed, Marwah Sami Ahmed, Ibrahim Khalil, Zahraa Saeed Fahad, Ahmed Dahham Hasan, Nizar Abdulateef Jassim   +7 more
wiley   +1 more source

An Investigation of Hyperostosis Frontalis Interna in a Modern Anatomical Body Donor Population

Clinical Anatomy, Volume 39, Issue 2, Page 211-233, March 2026.
ABSTRACT This research sought to examine the prevalence and severity of hyperostosis frontalis interna (HFI) in the Chicagoland anatomical body donor population. The study further aimed to elucidate potential demographic risk factors for HFI, including sex, age at death, and structural vulnerability index (SVI), as well as any common comorbidities, as ...
Amy C. Beresheim, Amanda Hall
wiley   +1 more source

Simultaneous presentation of bilateral acquired idiopathic Brown syndrome

, 2022
Purpose: Brown syndrome refers to limited elevation in adduction due to abnormal function of the superior oblique tendon-trochlea complex, which may be congenital or acquired.
Whyte, Jonathan P, Sharma, Richa
core   +1 more source

Fixed and Fluid: The Two Faces of Gender Roles—A Combined Study of Activity Patterns and Burial Practices in the European Neolithic

American Journal of Biological Anthropology, Volume 189, Issue 2, February 2026.
ABSTRACT Objectives This study investigates gender roles in the European Neolithic by analyzing activity‐related skeletal changes (ARSCs) and burial practices at two Polgár microregion sites in Hungary: Polgár‐Ferenci‐hát (5300–5070 cal. bce) and Polgár‐Csőszhalom (4800–4650 cal. bce). Materials and Methods A total of 125 well‐preserved adult skeletons
Sébastien Villotte, Tamás Szeniczey, Sacha Kacki, Alexandra Anders   +3 more
wiley   +1 more source

Emerging Role of Acitretin in Cutaneous Squamous Cell Carcinoma: From Prevention to Treatment

Dermatologic Therapy, Volume 2026, Issue 1, 2026.
Cutaneous squamous cell carcinoma (cSCC) is one of the most common cancers worldwide, with an increasing incidence that poses a significant public health challenge. Acitretin, a synthetic retinoid clinically used to treat epidermal hyperproliferative disorders, has emerged as a promising therapy for cSCC.
Fujin Zhou, Ziwei Kang, Zhenlin Li, Guorong Yan, Guolong Zhang, Suraiya Saleem   +5 more
wiley   +1 more source

A Novel MAP3K7 Variant Causing Loss of Function Identified in a Family With Cardiospondylocarpofacial Syndrome: Functional Validation and Molecular Insights

Human Mutation, Volume 2026, Issue 1, 2026.
Mitogen‐activated protein kinase kinase kinase 7 (MAP3K7), also known as transforming growth factor‐β–activated kinase 1 (TAK1), is a widely expressed kinase that plays a crucial role in various cellular processes variants in the MAP3K7 gene have been implicated in two distinct genetic disorders: frontometaphyseal dysplasia Type 2 (FMD2) and ...
Ting Zhu, Jiamin Shi, Jia Li, Tingmin Zhou, Xinru Fu, Fengzhen Xu, Chuangjie Gu, Danping Wang, Ruiting Wu, Li Liu, Jingling Shen, Dan Wang, Harleen Khatra   +12 more
wiley   +1 more source

Rett Syndrome: Revised diagnostic criteria and nomenclature [PDF]

, 2010
Objective: Rett syndrome (RTT) is a severe neurodevelopmental disease that affects approximately 1 in 10,000 live female births and is often caused by mutations in Methyl-CpG-binding protein 2 (MECP2). Despite distinct clinical features, the accumulation
Leonard, Helen, Zappella, M., Angus J. Clarke, Bailey, Mark E. S., Daniel G. Glaze, Clarke, A.J., Zappella, Michele, Kaufmann, Walter E., Neul, J.L., null Jeffrey L. Neul, John Christodoulou, N. Carolyn Schanen, Christodoulou, John, Percy, Alan K., Leonard, H., Michele Zappella, Walter E. Kaufmann, Mark E. S. Bailey, Neul, Jeffrey L., Kaufmann, W.E., RENIERI, ALESSANDRA, Schanen, N. Carolyn, Glaze, Daniel G., Bailey, M.E., Clarke, Angus John, Helen Leonard, Bailey, M.E.S., Bahi Buisson, N., Christodoulou, J., Peter Huppke, Percy, A.K., Bahi-Buisson, N., null null, RettSearch Consortium, MARI, FRANCESCA, Renieri, A., Alessandra Renieri, Nadia Bahi-Buisson, Bahi-Buisson, Nadia, Alan K. Percy, Huppke, Peter, Clarke, Angus J., Glaze, D.G., Schanen, N.C., Huppke, P.   +44 more
core   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Transporters

British Journal of Pharmacology, Volume 182, Issue S1, Page S404-S496, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Laura Amarosi, Catriona M. H. Anderson, Philip M. Beart, Stefan Broer, Paul A. Dawson, Gergely Gyimesi, Bruno Hagenbuch, James R. Hammond, Jules C. Hancox, Michal Hershfinkel, Ken‐ichi Inui, Yoshikatsu Kanai, Stephan Kemp, Edmund R. S. Kunji, Gavin Stewart, Sotiria Tavoulari, David T. Thwaites, Tiziano Verri   +28 more
wiley   +1 more source