Results 11 to 20 of about 1,452 (104)

SAPHO Syndrome Presenting With Severe Inflammatory Back Pain (Sacroiliitis) and Rare Retinol Associated Myopathy in an Iraqi Adolescent Male: A Case Report and Literature Review

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT SAPHO syndrome is a rare autoinflammatory disorder characterized by synovitis, acne, pustulosis, hyperostosis, and osteitis. Although musculoskeletal and dermatologic manifestations are well recognized, extra‐articular involvement remains uncommon, particularly muscular inflammation.
Farah Jaafar Mahdi, Ali Saad Al‐Shammari, Mustafa Majid Hameed, Marwah Sami Ahmed, Ibrahim Khalil, Zahraa Saeed Fahad, Ahmed Dahham Hasan, Nizar Abdulateef Jassim   +7 more
wiley   +1 more source

An Investigation of Hyperostosis Frontalis Interna in a Modern Anatomical Body Donor Population

Clinical Anatomy, Volume 39, Issue 2, Page 211-233, March 2026.
ABSTRACT This research sought to examine the prevalence and severity of hyperostosis frontalis interna (HFI) in the Chicagoland anatomical body donor population. The study further aimed to elucidate potential demographic risk factors for HFI, including sex, age at death, and structural vulnerability index (SVI), as well as any common comorbidities, as ...
Amy C. Beresheim, Amanda Hall
wiley   +1 more source

Fixed and Fluid: The Two Faces of Gender Roles—A Combined Study of Activity Patterns and Burial Practices in the European Neolithic

American Journal of Biological Anthropology, Volume 189, Issue 2, February 2026.
ABSTRACT Objectives This study investigates gender roles in the European Neolithic by analyzing activity‐related skeletal changes (ARSCs) and burial practices at two Polgár microregion sites in Hungary: Polgár‐Ferenci‐hát (5300–5070 cal. bce) and Polgár‐Csőszhalom (4800–4650 cal. bce). Materials and Methods A total of 125 well‐preserved adult skeletons
Sébastien Villotte, Tamás Szeniczey, Sacha Kacki, Alexandra Anders   +3 more
wiley   +1 more source

Emerging Role of Acitretin in Cutaneous Squamous Cell Carcinoma: From Prevention to Treatment

Dermatologic Therapy, Volume 2026, Issue 1, 2026.
Cutaneous squamous cell carcinoma (cSCC) is one of the most common cancers worldwide, with an increasing incidence that poses a significant public health challenge. Acitretin, a synthetic retinoid clinically used to treat epidermal hyperproliferative disorders, has emerged as a promising therapy for cSCC.
Fujin Zhou, Ziwei Kang, Zhenlin Li, Guorong Yan, Guolong Zhang, Suraiya Saleem   +5 more
wiley   +1 more source

A Novel MAP3K7 Variant Causing Loss of Function Identified in a Family With Cardiospondylocarpofacial Syndrome: Functional Validation and Molecular Insights

Human Mutation, Volume 2026, Issue 1, 2026.
Mitogen‐activated protein kinase kinase kinase 7 (MAP3K7), also known as transforming growth factor‐β–activated kinase 1 (TAK1), is a widely expressed kinase that plays a crucial role in various cellular processes variants in the MAP3K7 gene have been implicated in two distinct genetic disorders: frontometaphyseal dysplasia Type 2 (FMD2) and ...
Ting Zhu, Jiamin Shi, Jia Li, Tingmin Zhou, Xinru Fu, Fengzhen Xu, Chuangjie Gu, Danping Wang, Ruiting Wu, Li Liu, Jingling Shen, Dan Wang, Harleen Khatra   +12 more
wiley   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Transporters

British Journal of Pharmacology, Volume 182, Issue S1, Page S404-S496, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Laura Amarosi, Catriona M. H. Anderson, Philip M. Beart, Stefan Broer, Paul A. Dawson, Gergely Gyimesi, Bruno Hagenbuch, James R. Hammond, Jules C. Hancox, Michal Hershfinkel, Ken‐ichi Inui, Yoshikatsu Kanai, Stephan Kemp, Edmund R. S. Kunji, Gavin Stewart, Sotiria Tavoulari, David T. Thwaites, Tiziano Verri   +28 more
wiley   +1 more source

Hierarchical Superposition Framework Reveals the Complex Effects of Natural Medicine Formulas

Advanced Intelligent Systems, Volume 7, Issue 11, November 2025.
A novel hierarchical superposition pharmacological model incorporates the principle of hierarchical structures from physics to simulate the spatiotemporal dynamics of drug combinations, to elucidate the universal law underlying drug combination effects. By modeling cross‐level causal transmission and attenuation, it advances beyond traditional additive
Weifeng Liang, Dingsi Xiang, Shengli Mi, Jiajun Huang   +3 more
wiley   +1 more source

Transforming Growth Factor‐Beta Signaling in Cancer: Therapeutic Implications, Challenges, and Pathways to Progress

MedComm – Oncology, Volume 4, Issue 3, September 2025.
TGF‐β inhibition is emerging as a promising cancer therapy, yet translating laboratory success to bedside implementation has suffered significant setbacks. The associated challenges include adverse drug reactions, inadequate predictive models, and activation of alternative signaling pathways.
Faizah A. Alabi, Izuchukwu F. Okpalanwaka, Adenike Oyegbesan, Ebenezar Okoyeocha, Mariam Oladejo, Sikiru O. Imodoye   +5 more
wiley   +1 more source

Phosphatidylcholine Ameliorates Palmitic Acid‐Induced Lipotoxicity by Facilitating Endoplasmic Reticulum and Mitochondria Contacts in Intervertebral Disc Degeneration

JOR SPINE, Volume 8, Issue 2, June 2025.
The abnormal lipotoxic condition in nucleus pulposus (NP) cells from advanced‐stage intervertebral disc degeneration (IDD) was identified through untargeted LC/MS metabolomics and magnetic resonance spectroscopy. The palmitic acid accumulation resulted in endoplasmic reticulum stress, mitochondrial damage, lipid droplet accumulation, and senescence of ...
Shuangshuang Tu, Yijun Dong, Chuanfu Li, Mingxin Jiang, Liqun Duan, Wenzhi Zhang, Xi Chen   +6 more
wiley   +1 more source

Impact of Working From Home on the Psychological Well‐Being of 365 European Patients With Rheumatic Diseases During COVID‐19 Pandemic. Results of the REUMAVID Study

Musculoskeletal Care, Volume 23, Issue 2, June 2025.
ABSTRACT Objective To evaluate the impact of home working on the psychological well‐being of European patients with Rheumatic and Musculoskeletal Diseases (RMDs) during the COVID‐19 pandemic. Methods REUMAVID is a cross‐sectional study that collected data through an online survey in seven European countries during the COVID‐19 pandemic: Phase 1 (April ...
Marco Garrido‐Cumbrera, Helena Marzo‐Ortega, José Correa‐Fernández, Laura Christen, Victoria Navarro‐Compán   +4 more
wiley   +1 more source