Results 191 to 200 of about 192,697 (373)

Long‐term outcome after allogeneic stem cell transplantation for GATA2 deficiency: An analysis of 67 adults and children from France and Belgium

open access: yesBritish Journal of Haematology, EarlyView.
The overall survival of patients receiving an allogeneic haematopoietic stem cell transplant (HSCT) for GATA2 deficiency was significantly better if they were transplanted recently, with a bone marrow or cord blood graft and if the transplant was performed before the onset of excess blast. Excess blast before HSCT was the only factor associated with an
Flore Sicre de Fontbrune   +20 more
wiley   +1 more source

Understanding erythroid physiology and pathology in humanized mice: A closer look

open access: yesBritish Journal of Haematology, EarlyView.
Erythropoiesis, the formation of red blood cells (RBCs) from haematopoietic stem cells (HSCs), is vital for understanding conditions like anaemia and haemoglobinopathies. However, studying this process in vivo is challenging due to the lack of accurate models.
Lu Lu   +7 more
wiley   +1 more source

The IKZF1 N159S mutation is associated with poor outcome and a distinct molecular profile in adult patients with AML

open access: yesBritish Journal of Haematology, EarlyView.
Summary IKZF1 mutations are recurrent alterations in acute myeloid leukaemia (AML), and hotspot point mutation, N159S, has recently been associated with unique gene expression and adverse risk. To better understand the molecular and clinical associations of IKZF1 N159S‐mutated AML, we performed a pooled analysis of 4136 AML patients.
Sebastian Stasik   +18 more
wiley   +1 more source

1791 Lymphoid Interstitial Pneumonitis (LIP) in children with Acquired Immunodeficiency Syndrome (AIDS) prodrome [PDF]

open access: bronze, 1985
Marina I Liscano   +3 more
openalex   +1 more source

Heterozygous germline TET2 loss‐of‐function variants associated with an ALPS‐like phenotype

open access: yesBritish Journal of Haematology, EarlyView.
Summary Germline homozygous loss‐of‐function mutations in TET2 result in significant childhood immunodeficiency that resembles autoimmune lymphoproliferative syndrome and predisposes one to lymphoma. The implications of heterozygous variants are less well understood.
Sean Harrop   +13 more
wiley   +1 more source

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