Results 111 to 120 of about 222 (145)
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Molecular basis of congenital and acquired long QT syndromes
Journal of Electrocardiology, 2004In the United States, over 1,000 individuals will die suddenly each day due to a fatal ventricular arrhythmia. The vast majority of these individuals are middle-aged or elderly with coronary artery disease. Although less than 1% of these sudden cardiac deaths stem from a cardiac channelopathy like congenital long QT syndrome (LQTS), these deaths are ...
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Congenital and acquired long QT syndromes.
The Canadian journal of cardiology, 2003Exploration into the underlying genetic causes of congenital long QT syndrome (LQTS) has opened the door to our understanding of repolarization disorders. Expression of LQTS mutations has led to an improved understanding of the mechanisms of arrhythmogenesis, clinical diagnostic tools and channel specific therapy.
Bruce D, Walker +6 more
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Mechanisms of acquired long QT syndrome in patients with propionic academia
Heart Rhythm, 2016Propionic acidemia (PROP) is a rare metabolic disorder caused by deficiency of propionyl-CoA carboxylase. PROP patients demonstrate QT prolongations associated with ventricular tachycardia and syncopes. Mechanisms responsible for this acquired long QT syndrome (acqLQTS) are unknown.The aim of the study was to investigate acute and chronic effects of ...
Bodi, Ilona +8 more
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Case report, aetiology, and treatment of an acquired long-QT syndrome
Acta Clinica Belgica, 2014Acquired long-QT syndrome is an iatrogenic disorder, usually induced by drugs, which can cause life-threatening arrhythmias. We present a case report on an acquired long-QT syndrome with an interesting confluence of circumstances, and comment on aetiology and treatment.
P J, Van Asbroeck +2 more
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Acquired (Drug-Induced) Long QT Syndrome
2008The most common cause of acquired drug-induced long QT syndrome (ADILQTS) in clinical practice is an exposure of the heart to drugs known for their potential to prolong the QT interval. It has long been recognized that most drugs that prolong the duration of the QT interval can cause fatal tachyarrhythmias. However, it took decades to sensitize medical
Jeffrey S. Litwin +2 more
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[Acquired long QT syndrome: a dominant problem?].
Annales de cardiologie et d'angeiologie, 2007QT prolongation is essentially of pharmacologic origin. It is principally linked to a block of the outward potassium current Ikr, with as a consequence a prolongation of the repolarisation causing early after potentials and re-entry. The term "repolarisation reserve" expresses the variable risk of arrhythmia among individuals under the same drug ...
C, Barnay +9 more
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[ECG pearl: acquired long QT syndrome].
Orvosi hetilap, 2019Authors report the case of a patient with drug-induced long QT syndrome. This case highlights the importance of ECG signs of LQTS that may lead to torsade de pointes tachycardia. The patient received the QT prolonging moxifloxacine and the QT remained long even after the offending drug was discontinued. Orv Hetil. 2018; 159(39): 1607-1610.
János, Tomcsányi, Kristóf, Tomcsányi
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Clinical and therapeutic aspects of congenital and acquired long QT syndrome
The American Journal of Medicine, 2002The long QT syndrome is characterized by prolongation of the corrected QT (QTc) interval on the surface electrocardiogram. It is associated with precipitation of a polymorphic ventricular tachycardia, torsade de pointes, which may cause sudden death.
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Molecular Genetics of the Acquired Long QT Syndrome
2000The previous chapter has outlined the clinical conditions under which arrhythmias occur in patients with the congenital long QT syndrome (LQTS). One such condition - identified in only a handful of patients to date — is administration of a QT-prolonging drug; this finding indicates that the congenital form of LQTS and the drug-associated form overlap ...
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